DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GLR2.7

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_180476.3	Gene:	GLR2.7 / 817460	AraportID:	AT2G29120	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	1010	Identity:	193/1010 - (19%)
Similarity:	372/1010 - (36%)	Gaps:	258/1010 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHFCWISLIILSLSRVQAQFYGGNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGVP 65
            :|..:..|.:.|::...:.|     |:..|..:.||.:...|:.:.:.|....|:.::.||
plant    47 LHTSFSKLCLTSINISLSDF-----YKYHSDYTTRLAIHIRDSMEDVVQASSAALDLIKNE---- 102

  Fly    66 LVGETEQVAYGNSVQAFAQLCRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFI-----YPHLS 125
                                      .|.|:.||.....|..::...|...:|.|     .|.|:
plant   103 --------------------------QVSAIIGPRTSMQAEFMIRLADKSQVPTITFSATCPLLT 141

  Fly   126 WGSNPDGFNLHPSPEDIA--NALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVM 188
            ..::|  :.:..:.:|.:  .|:..||..|.|...:..|...|:.:.:..|:|..........|.
plant   142 SINSP--YFVRATLDDSSQVKAIAAIVKSFGWRNVVAIYVDNEFGEGILPLLTDALQDVQAFVVN 204

  Fly   189 RYDLNLNGNYKSVLRRIRK--SEDSRIVVV--GSTTGVAELLRQAQQVGIMNEDYTYII--GNLN 247
            |..:....|...:|:.:.|  :..:|:.||  ..|.|. ...::|:::|:|.|.|.:::  |.:|
plant   205 RCLIPQEANDDQILKELYKLMTMQTRVFVVHMPPTLGF-RFFQKAREIGMMEEGYVWLLTDGVMN 268

  Fly   248 L-----HTFDLEEYKYSEANITGIRMFSPDQEEVRDL---MEKLHQELGESEPVNSGSTFITMEM 304
            |     ....||..:    .:.|:|...|..:::::.   .||:..:.|..|.:|.        .
plant   269 LLKSNERGSSLENMQ----GVLGVRSHIPKSKKLKNFRLRWEKMFPKKGNDEEMNI--------F 321

  Fly   305 AL-TYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRN--------YMRSL-----EIKE 355
            || .||::..:|...:....:      |.|:|:....|:...|        |..||     .::.
plant   322 ALRAYDSITALAMAVEKTNIK------SLRYDHPIASGNNKTNLGTLGVSRYGPSLLKALSNVRF 380

  Fly   356 KTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWE----------------------------E 392
            ..:.|.........:...||||.:..|....:|.|.                            :
plant   381 NGLAGEFELINGQLESSVFDVINIIGSEERIIGLWRPSNGIVNAKSKNTTSVLGERLGPVIWPGK 445

  Fly   393 GKDFE--FQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLI 455
            .||..  :|.|   .|...:..|..|.|.|:..:.....|.::.:..          .||.:::.
plant   446 SKDVPKGWQIP---TNGKMLRVGIPVKKGFLEFVDAKIDPISNAMTP----------TGYCIEIF 497

  Fly   456 KELADKLGFNFTFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPF 520
            :.:..||.::...:     |.:|.....:...|:.::..|..|..:.|:||.:.|...:||::|:
plant   498 EAVLKKLPYSVIPK-----YIAFLSPDENYDEMVYQVYTGAYDAVVGDVTIVANRSLYVDFTLPY 557

  Fly   521 MNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEE 585
            ...|::::.  |.|.....:.|:.|:|.::|:        .:.|||:.  :..|.|
plant   558 TESGVSMMV--PLKDNKNTWVFLRPWSLDLWV--------TTACFFVF--IGFIVW--------- 601

  Fly   586 PEELENQFT----------INNSLWFTTGALLQQGSEIAPKALS--TRTISAIWWFFTLIMVSSY 638
              .||::..          |..|.||....:.....|   |.:|  .|.:..:|.|..|:::.||
plant   602 --ILEHRVNTDFRGPPHHQIGTSFWFAFSTMNFAHRE---KVVSNLARFVVLVWCFVVLVLIQSY 661

  Fly   639 TANLAAFLTIENPTSPINSVKDLADNKDDVQY------------------GAKRTGST---RNFF 682
            ||||.:|.|::.....:.:.|||.....::.|                  ..|..||.   ...|
plant   662 TANLTSFFTVKLLQPTVTNWKDLIKFNKNIGYQRGTFVRELLKSQGFDESQLKPFGSAVECDELF 726

  Fly   683 STS------EEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLT 741
            |..      :|..|||:         :|.:|:          :||..:..|    |.|.
plant   727 SNGTITASFDEVAYIKV---------ILSQNS----------SKYTMVEPS----FKTA------ 762

  Fly   742 KVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSE 806
                     |:|....|..|..|..::|:|.:.:...:..::|||:.:  ...|...:.....:.
plant   763 ---------GFGFVFPKKSPLTDDVSRAILNVTQGEEMQHIENKWFKK--PNNCPDLNTSLSSNH 816

  Fly   807 LGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRF---SENER 868
            |.:.:..|::::..|.|.::::|.:   ..|:|:    ::....|.....||..::|   :.:|:
plant   817 LSLSSFWGLFLIAGIASFLALLIFV---ANFLYE----HKHTLFDDSENSFRGKLKFLVRNFDEK 874

  Fly   869 PLKS----AQSIYSRSRNSSQSIESLKTDSEENMP 899
            .:||    ..::::.|...:|...|..||....:|
plant   875 DIKSHMFKENAVHNVSSPITQGSSSPLTDQSTPLP 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	79/424 (19%)
		ANF_receptor	46..380	CDD:279440	71/368 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	82/409 (20%)
		Lig_chan	549..819	CDD:278489	60/308 (19%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor	40..421	CDD:107361	83/429 (19%)
		ANF_receptor	54..405	CDD:279440	79/406 (19%)
		GluR_Plant	460..799	CDD:270404	83/417 (20%)
		Lig_chan	584..832	CDD:278489	60/311 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.930