DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GLR2.8

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001324459.1	Gene:	GLR2.8 / 817459	AraportID:	AT2G29110	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	948	Identity:	198/948 - (20%)
Similarity:	358/948 - (37%)	Gaps:	263/948 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 NSVQAFAQLCRLMQS-GVGAVFGPAARHTASHLLNACDSKDIPFI-----YPHLS--------WG 127
            ::|||.|....|:|: .|.|:.||.....|..::...:...:|.|     .|.|:        .|
plant    82 DTVQASAAALDLIQNEQVSAIIGPIDSMQAKFMIKLANKTQVPTISFSATSPLLTSIKSDYFVRG 146

  Fly   128 SNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAE-------YLKILDHLMTRYGIKGPVI 185
            :..|.:.:        .|:..|...|.|...:..|...|       ||  .|.|..        :
plant   147 TIDDSYQV--------KAIAAIFESFGWRSVVAIYVDNELGEGIMPYL--FDALQD--------V 193

  Fly   186 KVMRYDLNLNGNYKSVLRRIRK--SEDSRIVVVGSTTGVA-ELLRQAQQVGIMNEDYTYIIGN-- 245
            :|.|..:....|...:|:.:.|  :..:|:.||...:.:| .:..:|.::|:|.|.|.:::.|
plant   194 QVDRSVIPSEANDDQILKELYKLMTRQTRVFVVHMASRLASRIFEKATEIGMMEEGYVWLMTNGM 258

  Fly   246 ----------LNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFI 300
                      .:|:|.|         .:.|:|...|..:.:.|...:..:...:..|      ::
plant   259 THMMRHIHHGRSLNTID---------GVLGVRSHVPKSKGLEDFRLRWKRNFKKENP------WL 308

  Fly   301 TMEMAL----TYDAVRVIA---ETT--KHLPYQPQMLNCSERHDNVQPDGST-FRNYMRSL---- 351
            ..::::    .||:...:|   |.|  ...||.    |.|...:|:...|:. ...|..||
plant   309 RDDLSIFGLWAYDSTTALAMAVEKTNISSFPYN----NASGSSNNMTDLGTLHVSRYGPSLLEAL 369

  Fly   352 -EIKEKTITGR---------------IYFEGNVRK--GFTFDVIELQTSGLVKVGTWEEGKDFEF 398
             ||:...:.||               |.|.||..:  ||.     ..::|||.|.: .:...|..
plant   370 SEIRFNGLAGRFNLIDRQLESPKFEIINFVGNEERIVGFW-----TPSNGLVNVNS-NKTTSFTG 428

  Fly   399 QR------PPQA----------VNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQF 447
            :|      |.::          .|...|..|..|.|.|...:.|.|.|..::...
plant   429 ERFGPLIWPGKSTIVPKGWEIPTNGKKIKVGVPVKKGFFNFVEVITDPITNITTP---------- 483

  Fly   448 QGYGVDLIKELADKLGFN-----FTFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTIT 507
            :||.:|:.:....||.::     :.|....:||          ..::.::..|..|..:.|:|||
plant   484 KGYAIDIFEAALKKLPYSVIPQYYRFESPDDDY----------DDLVYKVDNGTLDAVVGDVTIT 538

  Fly   508 SEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLS 572
            :.|....||::|:...|::::...........:.|:.|:..::|:        .:.|||::  :.
plant   539 AYRSLYADFTLPYTESGVSMMVPVRDNENKNTWVFLKPWGLDLWV--------TTACFFVL--IG 593

  Fly   573 PIEWDNPYPCIEEPEELENQF------TINNSLWFTTGALLQQGSEIAPKALS--TRTISAIWWF 629
            .:.|      :.| ..:...|      .|..|.||:...::....|   |.:|  .|.:..:|.|
plant   594 FVVW------LFE-HRVNTDFRGPPHHQIGTSFWFSFSTMVFAHRE---KVVSNLARFVVVVWCF 648

  Fly   630 FTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDV--QYGAKRTGSTRNF----------- 681
            ..|::..||||||.:|||::.......:||||..|.|.|  |:||    ..::|
plant   649 VVLVLTQSYTANLTSFLTVQRFQPAAINVKDLIKNGDYVGYQHGA----FVKDFLIKEGFNVSKL 709

  Fly   682 --FSTSEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVG 744
              |.:|||...:..|..::|           ..|:|      |:|....|      :.|:...:.
plant   710 KPFGSSEECHALLSNGSISA-----------AFDEV------AYLRAILS------QYCSKYAIV 751

  Fly   745 DP-LDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDD--DGPSE 806
            :| ....|:|.|..:|.|.....:||:|.:.:...:..::|||:         .|.:|  |..:.
plant   752 EPTFKTAGFGFAFPRNSPLTGDVSKAILNVTQGDEMQHIENKWF---------MKQNDCPDPKTA 807

  Fly   807 LGVDNLS-----GIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCD--------ALAEEFR 858
            |..:.||     |::::..|.|.::::|.:.   .|:|:....    .||        .|...||
plant   808 LSSNRLSLRSFWGLFLIAGIASFLALLIFVF---LFLYENRHT----LCDDSEDSIWRKLTSLFR 865

  Fly   859 IVIRFSENERPLKS----AQSIYSRSRNSSQSIESLKT 892
                 :.:|:.:||    :.:::..|...:|.|.|..|
plant   866 -----NFDEKDIKSHTFKSSAVHHVSSPMTQYIPSPST 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	78/387 (20%)
		ANF_receptor	46..380	CDD:279440	74/370 (20%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	88/399 (22%)
		Lig_chan	549..819	CDD:278489	69/300 (23%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	77/378 (20%)
GLR2.8	NP_001324459.1	GluR_Plant	454..795	CDD:270404	90/407 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.930