DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GLR2.9

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001325277.1	Gene:	GLR2.9 / 817458	AraportID:	AT2G29100	Length:	942	Species:	Arabidopsis thaliana

Alignment Length:	928	Identity:	188/928 - (20%)
Similarity:	367/928 - (39%)	Gaps:	217/928 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 NSVQAFAQLCRLMQS-GVGAVFGPAARHTASHLLNACDSKDIPFI-----YPHLSWGSNPDGFNL 135
            ::|||.|....|::: .|.|:.||.....|..::...:...:|.|     .|.|:...:|  :.:
plant    80 DTVQASAAALDLIKTEQVSAIIGPINSMQADFMIKLANKTQVPTITFSATSPLLTSIKSP--YFV 142

  Fly   136 HPSPEDIA--NALYDIVNQFEWSRFIFCYESAE----YLKILDHLMTRYGIKGPVIKVMRYDLNL 194
            ..:.:|.:  .|:..|...|.|.|.:..|...|    ::..|...:....:|..||.....|..:
plant   143 RATIDDSSQVRAIASIFKFFRWRRVVAIYVDNEFGEGFMPFLFDALQDVEVKRSVIPPEAIDDEI 207

  Fly   195 NGNYKSVLRRIRKSEDSRIVVVGSTTGVA-ELLRQAQQVGIMNEDYTYIIGN------------L 246
            ....:.::.|     .:|:.||...:.:| .:.:.|:.:|:|.|.|.:::.|            .
plant   208 QKELRKLMER-----QARVFVVHMESSLALRVFQIARDIGMMEEGYVWLMTNGMTHMMRHINNGR 267

  Fly   247 NLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAV 311
            :|:|.:         .:.|:|...|..:|:.|...:..:...:..|  |....:.:.....||::
plant   268 SLNTIE---------GVLGVRSHVPKSKELGDFRLRWKRTFEKENP--SMRDDLNVFALWAYDSI 321

  Fly   312 RVIAE-----TTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRI---YFEGNV 368
            ..:|:     .||.|.|           ||    |||..        |.:|..|.:   .:..::
plant   322 TALAKAVEKANTKSLWY-----------DN----GSTLS--------KNRTDLGNVGVSLYGPSL 363

  Fly   369 RKGFTFDVIELQTSGLVKVGTWEEGK--DFEFQRPP-QAVNF--------------NDIDDGSLV 416
            :|.|:    |::.:||.     .|.|  |.:.|.|. :.:||              :.:.|.:..
plant   364 QKAFS----EVRFNGLA-----GEFKLIDGQLQSPKFEIINFVGNEERIIGFWTPRDGLMDATSS 419

  Fly   417 NKTFI----------------------VLISVATKP-YASLVE-SIDTLIGNNQFQGYGVDLIKE 457
            ||..:                      :.:.|..|. :...|: :|:.:.......||.:::.:.
plant   420 NKKTLGPVIWPGKSKIVPKGWEIPGKKLRVGVPMKKGFFDFVKVTINPITNKKTPTGYAIEIFEA 484

  Fly   458 LADKLGFNFTFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMN 522
            ...:|.:...     .:|.|| ::.|:.:.::.::.:...|..:.|:|||:.|....||::||..
plant   485 ALKELPYLVI-----PEYVSF-ESPNNYNNLVYQVYDKTWDAVVGDITITANRSLYADFTLPFTE 543

  Fly   523 LGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEW--------DNP 579
            .|::::...........:.|::|:|.|:|:..|        |||:.  :..:.|        |..
plant   544 SGVSMMVPVRDNENKDTWVFLEPWSLELWVTTG--------CFFVF--IGFVVWLFEHRVNTDFR 598

  Fly   580 YPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAA 644
            .|         .|:.|..||||:...::....|.....|: |.:..:|.|..|::..||||:|.:
plant   599 GP---------PQYQIGTSLWFSFSTMVFAHRENVVSNLA-RFVVVVWCFVVLVLTQSYTASLTS 653

  Fly   645 FLTIENPTSPINSVKDLADNKDDVQY--GA--KRTGSTRNFFSTSEEPIYIKMNEYLNAHPEMLM 705
            |||:::....:.:|.||..|:|.|.|  ||  |.......|.....:|.     :......::|.
plant   654 FLTVQSLQPTVTNVNDLIKNRDCVGYQGGAFVKDILLGLGFHEDQLKPF-----DSAKDADDLLS 713

  Fly   706 ENNQQGV----DKV--------KSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVK 758
            :...:|:    |:|        :|.:||. ::|.|   |.|               .|:|.|..|
plant   714 KGKSKGIAAAFDEVAYLKAILSQSCSKYV-MVEPT---FKT---------------GGFGFAFPK 759

  Fly   759 NWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGP------SELGVDNLSGIYV 817
            |.|...:|::|:|.|.:..|..:::::|:.:        |:|...|      :.|.:.:..|::
plant   760 NSPLTGEFSRAILNLTQNNVTQQIEDRWFPK--------KNDCPDPMTALSSNRLNLSSFLGLF- 815

  Fly   818 VLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRN 882
             |:.|:.||..:.:.. ..|:|:..........|:|..:.:.:.:..: |:.:.|.....|...|
plant   816 -LIAGTAISFSLLVFV-ALFLYEHRHTLGDDSEDSLWRKLKFLFKIFD-EKDMNSHTFKNSAIHN 877

  Fly   883 SSQSIESLKTDSEENMPV 900
            .|..: :.||.|...:.:
plant   878 ISSPM-THKTPSPSTVQI 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	71/354 (20%)
		ANF_receptor	46..380	CDD:279440	66/335 (20%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	91/418 (22%)
		Lig_chan	549..819	CDD:278489	69/299 (23%)
GLR2.9	NP_001325277.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.930