DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GLR2.2

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	946	Identity:	180/946 - (19%)
Similarity:	351/946 - (37%)	Gaps:	232/946 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EASSGQ-----SIRLGLITDDATD-----------------RIRQTFEHAISVVNNELGVPLVGE 69
            |:|.||     .:.:|:::|..|.                 ..|..|:..: |||       ||:
plant    20 ESSRGQDNGKTQVNIGVVSDVGTSYPDVAMLCINMSLADFYSSRPQFQTRL-VVN-------VGD 76

  Fly    70 TEQVAYGNSVQAFAQLCRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFI-----YPHLSWGSN 129
            ::....|   .|.|.:..:....|.|:.||.....|..|:.......:|.:     .|.|:...:
plant    77 SKNDVVG---AATAAIDLIKNKQVKAILGPWTSMQAHFLIEIGQKSRVPVVSYSATSPSLTSLRS 138

  Fly   130 PDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNL 194
            |..|..........:|:..|:..|.|...:..|        :|:.... ||. |.:.....|:|:
plant   139 PYFFRATYEDSSQVHAIKAIIKLFGWREVVPVY--------IDNTFGE-GIM-PRLTDSLQDINV 193

  Fly   195 NGNYKSVLRRIRKSED------------SRIVVVGSTTGVAE-LLRQAQQVGIMNEDYTYIIGN- 245
            ...|:||:......:|            :|:.:|..::.:|. :..:|:::|:|...|.:|:.|
plant   194 RIPYRSVIPLNATDQDISVELLKMMNMPTRVFIVHMSSSLASTVFIKAKELGLMKPGYVWILTNG 258

  Fly   246 -----LNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMA 305
                 .:::...:|..:    .:.||:.:.|..:::.....:..:.            |..||:.
plant   259 VMDGLRSINETGIEAME----GVLGIKTYIPKSKDLETFRSRWKRR------------FPQMELN 307

  Fly   306 L----TYDAVRVIAETTKHLPYQPQMLNCSERHDNV-QPDGSTFRNYMRSL-----EIKEKTITG 360
            :    .|||...:|...:.........:..:...|| :.||.....:...|     .::.|.:.|
plant   308 VYGLWAYDATTALAMAIEDAGINNMTFSNVDTGKNVSELDGLGLSQFGPKLLQTVSTVQFKGLAG 372

  Fly   361 RIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDF--EFQRPPQAV------------------ 405
            ..:|.....:...|:::.:..:|...:|.|.||...  :..:.|:::
plant   373 DFHFVSGQLQPSVFEIVNMIGTGERSIGFWTEGNGLVKKLDQEPRSIGTLSTWPDHLKHIIWPGE 437

  Fly   406 ------------NFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKEL 458
                        |...:..|......|..|:.|...|..:     .|::     :|:.:|..:.:
plant   438 AVSVPKGWEIPTNGKKLRIGVPKRIGFTDLVKVTRDPITN-----STVV-----KGFCIDFFEAV 492

  Fly   459 ADKLGFNFTFRDGGNDYGSFNKTTNSTSG----MLKEIVEGRADLAITDLTITSEREEVIDFSIP 519
            ...:.::.::     ::..|.|.....:|    ::.::..|:.|..:.|.||.:.|...:||::|
plant   493 IQAMPYDVSY-----EFFPFEKPNGEPAGNHNDLVHQVYLGQFDAVVGDTTILANRSSFVDFTLP 552

  Fly   520 FMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIE 584
            ||..|:.::.....:.....|||:.|.|.|:||        .:|.||.:..:|  .|
plant   553 FMKSGVGLIVPLKDEVKRDKFSFLKPLSIELWL--------TTLVFFFLVGIS--VW-------- 599

  Fly   585 EPEELENQ----------FTINNSLWFTTGALLQQGSEIAPK----ALSTRTISAIWWFFTLIMV 635
               .||::          :..:...||....::     .||:    :...|::...|:|..|::.
plant   600 ---TLEHRVNSDFRGPANYQASTIFWFAFSTMV-----FAPRERVLSFGARSLVVTWYFVLLVLT 656

  Fly   636 SSYTANLAAFLTIE--NPTSPINSVKDLADNKDDVQYGAKRTG-------------STRNFFSTS 685
            .||||:||:.||.:  |||  |.|:..|....:.|.|  :||.             |:...|.|:
plant   657 QSYTASLASLLTSQQLNPT--ITSMSSLLHRGETVGY--QRTSFILGKLNETGFPQSSLVPFDTA 717

  Fly   686 EEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTK-VGDPLDE 749
            ||     .:|.|...|:      ..||.....||.|..|...        :.||..| |.:|.:.
plant   718 EE-----CDELLKKGPK------NGGVAAAFLGTPYVRLFLG--------QYCNTYKMVEEPFNV 763

  Fly   750 KGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVC--SAKSDDDGPS----ELG 808
            .|:|.......|.....::|:|::.|......|::.|:.:.... |  ...:.|..|:    :||
plant   764 DGFGFVFPIGSPLVADVSRAILKVAESPKAVELEHAWFKKKEQS-CPDPVTNPDSNPTVTAIQLG 827

  Fly   809 VDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKN 844
            |.:...:::|:.:..:::  :....:|:....|.|:
plant   828 VGSFWFLFLVVFVVCVLA--LGKFTFCFLWKTKGKD 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	73/414 (18%)
		ANF_receptor	46..380	CDD:279440	65/367 (18%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	90/404 (22%)
		Lig_chan	549..819	CDD:278489	69/305 (23%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	73/415 (18%)
		ANF_receptor	47..392	CDD:279440	65/381 (17%)
		HisJ	438..>587	CDD:223904	32/171 (19%)
		GluR_Plant	452..801	CDD:270404	90/412 (22%)
		Lig_chan	582..819	CDD:278489	65/286 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930