DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and grik5

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	897	Identity:	290/897 - (32%)
Similarity:	476/897 - (53%)	Gaps:	74/897 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SIRLGLITDDAT-----DRIRQTF--EHAISVVNNELGVPLVGETEQVAYGNSVQAFAQLCRLMQ 90
            |:|:..|.||::     :|:....  |:..||:.|.....:..:..::...:..:....:|:::.
Zfish    36 SVRMAAILDDSSVCGRGERLALALARENINSVMENPARARVEVDIFELQKDSQYETTDTMCQILP 100

  Fly    91 SGVGAVFGPAARHTASHLL-NACDSKDIPFI---------YPHLSWGSNPDGFNLHPSPEDIANA 145
            .||.:|.|||:...:..:: :.|..|:||.:         .|:|.:.|    ..|:||.||::.|
Zfish   101 KGVVSVIGPASSPASGSIVSHICGEKEIPHVKIGPEETPRLPYLRFAS----VTLYPSNEDLSLA 161

  Fly   146 LYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSED 210
            :..|:..|.:.........||.|..|:.|:.|:.|....:.:...|.||:..  .:|:.||..:.
Zfish   162 IGSILRSFSYPSASLVCAKAECLLRLEELIRRFLISRETLSIRMLDDNLDPT--PLLKEIRDDKI 224

  Fly   211 SRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEE 275
            :.|::..:.:....:|::|.::|:.:..|.||:..::.....|::....::||.|..||:.....
Zfish   225 ATIIIDANASISYLILKKASELGMTSAFYKYILTTMDFPLLWLDDIVDEQSNIVGFSMFNTTHPF 289

  Fly   276 VRDLMEKLHQELGESEPVN--SGSTFITMEMALTYDAVRVIAETTKHLPYQPQM----LNCSERH 334
            ..:.:..|:....|...:|  .|.   .:..||.:|||.|:....:.|....::    |:|:.
Zfish   290 YLEFIRSLNLSWREGCDINPYPGP---ALSSALLFDAVHVVVSAVQELNRSQEIGVKPLSCTS-- 349

  Fly   335 DNVQPDGSTFRNYMRSLEIKEKTITGRIYFEG-NVRKGFTFDVIELQTSGLVKVGTWEEGKDFEF 398
            ..:...|::..||:|.:|.  ..:|||:.|.. ..|..:|..::|....|..::|.|........
Zfish   350 PQIWQHGTSLMNYLRMVEY--DGLTGRVEFNSKGQRTNYTLHILEKHRGGHKEIGIWYSNNTLLM 412

  Fly   399 QRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLG 463
            ......:|.::    :|.||: :::.::...||.....:.....||.|::|:.||:::||:|.|.
Zfish   413 NSTSLDINVSE----TLANKS-LIITTILENPYVMRKINYQEFEGNEQYEGFCVDMLRELSDILK 472

  Fly   464 FNFTFR--DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIA 526
            |.:..:  |.|. ||: .:...|.:||:.|::..:||||:...|||||||:|||||.|||.|||:
Zfish   473 FTYRIKLVDDGL-YGA-PEPNGSWTGMVGELINRKADLAVAAFTITSEREKVIDFSKPFMTLGIS 535

  Fly   527 ILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEE-LE 590
            |||.......|..|||:||||..|||::.:|||.||...|:..||||.||.||:||:.|..: ||
Zfish   536 ILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLSARLSPYEWYNPHPCLRERRDLLE 600

  Fly   591 NQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPI 655
            ||:|:.|||||..|..:||||||.|:|||||.:|.:||.||||::||||||||||||::....||
Zfish   601 NQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPI 665

  Fly   656 NSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVDKVKSGT 719
            .|..|||| :.::|||....|||..||..|....|.:|..|: :..|.:.:::.::|:.:|.: :
Zfish   666 ESPDDLAD-QTNIQYGTIHGGSTMTFFMNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVVN-S 728

  Fly   720 KYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKN 784
            |||||:|||..|::....||||::|..||.|||||.|....|:||:.:.|:|:|||...|..||.
Zfish   729 KYAFLLESTMNEYHRSLNCNLTQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKR 793

  Fly   785 KWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYE--- 846
            :||.   .|.| .|.:|.....||::|:.||:|||:.|.||::.::::.:.:...:.|:..|
Zfish   794 RWWE---GGKC-PKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFVWSTRRSAETDEVRP 854

  Fly   847 ------------VPFCDALAEEFRIVIRFSEN-----ERPLKSAQSIYSRSR 881
                        |..|..:..|||..:...::     .|||.|:.::...:|
Zfish   855 LSCDRQYHSHTTVSVCQEMLTEFRNAVSCKKSSRLRRRRPLSSSLALRHPTR 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	85/385 (22%)
		ANF_receptor	46..380	CDD:279440	78/352 (22%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	174/374 (47%)
		Lig_chan	549..819	CDD:278489	129/271 (48%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	85/386 (22%)
		ANF_receptor	55..392	CDD:279440	76/349 (22%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	18/76 (24%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	174/374 (47%)
		Lig_chan	558..828	CDD:278489	131/275 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760