DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and grid1a

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	975	Identity:	235/975 - (24%)
Similarity:	432/975 - (44%)	Gaps:	150/975 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISLIILSLSRVQAQFYGGNAYEASSGQSIRLGLITDDATDRIRQTFEHAIS--VVNNELGVPLVG 68
            :.|:::|||....|     ...|.:...|.:|.|.:....|..:.|:.|||  .:|::     :.
Zfish     1 MELLVISLSLWILQ-----CRSARADSIIHIGAIFEQNAIRDDEVFQLAISDLSLNDD-----IL 55

  Fly    69 ETEQVAY-------GNSVQAFAQLCRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSW 126
            ::|::.:       .|..||..:.|.||..|:.|:........|:.|.:..|:..|    |||..
Zfish    56 QSERITHSIKLIEPNNPFQAVQEACELMNQGILALVSSTGCAAANALQSLTDAMHI----PHLFI 116

  Fly   127 GSNPDG-----FNLHPSPED------------IANALYDIVNQFEWSRFIFCYESAEYLKILDHL 174
            ..|.||     ..|:|||:.            :.:.:..:|::..|.:||..|:|...::.|...
Zfish   117 QRNGDGTPRAECQLNPSPDGERYTLAARPPVRLNDVMITLVSELRWHKFIVFYDSEYDVRGLRGF 181

  Fly   175 MTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSE-----DS--RIVVVGSTTGVAELLRQAQQV 232
            :.:....|..:.:.:.|.|:...:.::...:|..|     |:  |.:::.|.......:.||.:.
Zfish   182 LDQASRMGLDVSLQQVDRNVTKVFSTLFSTMRMEELNRYRDTLRRAILLLSPRTAQVFIHQAVET 246

  Fly   233 GIMNEDYTYIIGNLNLHTFDLEEYKYSE-ANITGIRMFSP--DQEEVRDLMEKLHQ--------E 286
            .:.::|..::..|..:...::.|..:|. ..:|.||...|  ....:| .|...|:        :
Zfish   247 NLASKDSHWVYANEEVSDTEIMELVHSALGRMTVIRQIFPLWRDTNIR-CMRNNHRISSLLCDPQ 310

  Fly   287 LGESEPVNSGSTFITMEMALTYDAVRVIA-------ETTKHLPYQPQMLNCSERHDNVQPDGSTF 344
            .|..:.:...|.::       ||:|.::|       |..|.  :....|||..:.......|.:.
Zfish   311 EGYLQSLEVSSLYL-------YDSVLMLANAFYRKLEDRKW--HSMASLNCMRKSTKPWNGGWSM 366

  Fly   345 RNYMRSLEIKEKTITGRIYFEGN-VRKGFTFDVIEL---QTSG--LVKVGTWEEGKDFEFQRPPQ 403
            .:.::...|  ..:||.:.|..| ......|:::..   :|.|  :.::.||:..:...     .
Zfish   367 LDTIQKGRI--SGLTGLMDFRSNGANSHVQFEILGTSYSETFGKDVKRLATWDSDRGLN-----G 424

  Fly   404 AVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGN-NQFQGYGVDLIKELADKLGFNF- 466
            ::..|..|.|  :....:.::::..:|:..:.|:|   :|. .:::|:.:|::..||..|||.:
Zfish   425 SLRENRADHG--MQGITLKVVTLLEEPFVMVAENI---LGQPKRYKGFSIDVLDALAKILGFKYE 484

  Fly   467 TFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVK 531
            .::.....||| .:|..|.:||:.|::..|||:||:.:|||.|||.|:|||..:::..:.||..|
Zfish   485 MYQVADAKYGS-PQTNGSWNGMIGELIGKRADVAISAITITPERENVVDFSKRYLDYSVGILMTK 548

  Fly   532 PQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTIN 596
            .::. ..:||.:.||...||..:..|...|.:..|::.|:..:...|| |...:|..:...|  .
Zfish   549 TEER-LNIFSLLAPFDLAVWACIAAAIPVVGVMVFLLRRVQSVRSQNP-PGPHQPASVTTSF--Q 609

  Fly   597 NSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDL 661
            :::|...||.:|||.|....:::.|.....||.||||:.|||||||||:||:....:.|.:.:||
Zfish   610 SAIWIVYGAFVQQGGESFMSSMALRIAMGSWWLFTLIVCSSYTANLAAYLTVSRMDNAIRTFQDL 674

  Fly   662 ADNKDDVQYGAKRTGSTRNFF-----------STSEEPIYIKMNEYLNAHPEMLMENNQQGVDKV 715
            : .:.::.||..|..:...:|           ||..| ::..:|:  |...:..:.:..:|:.||
Zfish   675 S-KQSEINYGTVRESAVFEYFRVKGTNPLEQDSTFAE-LWRTINK--NQGQDNSVTSPAEGIRKV 735

  Fly   716 KSGTKYAFLMESTSIEFN--TVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGV 778
            |. ..||||.:...:|:.  |..:|.|...|:.:..||||:|:....||||.|::.:|:|||:|.
Zfish   736 KR-DPYAFLWDMAVLEYAALTDDDCTLVVTGNGMSSKGYGLALQHGSPYRDLFSQKILDLQEKGD 799

  Fly   779 LARLKNKWWNEVGAGVCSAKSDDDGPSE---LGVDNLSGIYVVLVIGSIISIIISIL-CW----- 834
            |..||.|||...|.  |......:..:|   |.:.:.:|::.:|..|.:::.:::.| .|
Zfish   800 LDILKQKWWPRKGR--CDLDKHAEPQTEGRALRLHSFAGVFCILAAGLLLACLVAALESWWNGPR 862

  Fly   835 CYFVYKK---------------AKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSS 884
            |.....|               |.|...|......:.      :.|.||..:..|:.|:..|..|
Zfish   863 CQRAQPKEDTKGCALEMVSGSLAYNEIAPAAGCARDV------WPERERDWEDTQAFYTGQRGES 921

Fly 885 884
Zfish 922 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	81/418 (19%)
		ANF_receptor	46..380	CDD:279440	75/388 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	122/385 (32%)
		Lig_chan	549..819	CDD:278489	87/285 (31%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	81/424 (19%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	122/384 (32%)
		DNA_pol3_gamma3	<915..1044	CDD:331207	2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591114
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740