DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Grid2

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	901	Identity:	229/901 - (25%)
Similarity:	413/901 - (45%)	Gaps:	137/901 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ASSGQSIRLGLITDDATDRIRQTFEHAISVVN-NELGVPLVGETEQVAY-------GNSVQAFAQ 84
            |:|...|.:|.|.|::..:..:.|..|:..:| ||    .:.:||::.:       .|..||..:
  Rat    21 ATSDSIIHIGAIFDESAKKDDEVFRTAVGDLNQNE----EILQTEKITFSVTFVDGNNPFQAVQE 81

  Fly    85 LCRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNP------------DGFNLHP 137
            .|.||..|:.|:.......:|..|.:..|:..||.::...|....|            |.:.|..
  Rat    82 ACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSV 146

  Fly   138 SPEDIAN-ALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLN------ 195
            .|....| .:..:|.::.|.:||..|:|...::.:...:.:...:|..:.:.:.:.|:|
  Rat   147 RPPVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTL 211

  Fly   196 ---------GNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTF 251
                     ..|:..|||       .|:|:...| ....:.:..:..::..|..:||.|..::..
  Rat   212 FDTMRIEELNRYRDTLRR-------AILVMNPAT-AKSFISEVVETNLVAFDCHWIIINEEINDV 268

  Fly   252 DLEE-YKYSEANITGIRMFSPDQEEVRDLMEKLHQELGES--EPVNSGSTFITMEMALTYDAVRV 313
            |::| .:.|...:|.||...|..:.:.....:.:..:..:  :|.:..:..:.:.....||.|.:
  Rat   269 DVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLL 333

  Fly   314 IAET-TKHLP----YQPQMLNCSERHDNVQPDGSTFRNYMRSLEIKEK----TITGRIYF-EGNV 368
            :|.. .|.|.    :....|:|..::......|.:.      ||..:|    .:||.:.| |...
  Rat   334 LANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSM------LETIKKGGVNGLTGDLEFGENGG 392

  Fly   369 RKGFTFDVI-----ELQTSGLVKVGTWEEGKDFEFQRPPQAVNFNDIDDGSLVNKTF------IV 422
            .....|:::     |....|:.|:|.|         .|...:|      |||.:|..      :|
  Rat   393 NPNVHFEILGTNYGEELGRGVRKLGCW---------NPVTGLN------GSLTDKKLENNMRGVV 442

  Fly   423 L--ISVATKPYASLVESIDTLIGN-NQFQGYGVDLIKELADKLGFNF-TFRDGGNDYGSFNKTTN 483
            |  ::|..:|:..:.|::   :|. .::||:.:|::..|::.||||: .:....:.||| .:...
  Rat   443 LRVVTVLEEPFVMVSENV---LGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGS-PQEDG 503

  Fly   484 STSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSS 548
            :.:|::.|:|..|||:.|:.||||.:||.|:||:..:|:..:.:|..:.:|... :|:.:.||..
  Rat   504 TWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVD-MFACLAPFDL 567

  Fly   549 EVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEI 613
            .:|..:....|.|.|..::      :.|.|| |.::.......  |:.||:||..|:.:|||.|:
  Rat   568 SLWACIAGTVLLVGLLVYL------LNWLNP-PRLQMGSMTST--TLYNSMWFVYGSFVQQGGEV 623

  Fly   614 APKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGST 678
            ....|:||.:...||.|.||::|||||||||||||....|.|.|::||: .:.|:.||.....:.
  Rat   624 PYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLS-KQTDIPYGTVLDSAV 687

  Fly   679 ------RNFFSTSEEPIYIKMNEYLNAHPEMLMENN----QQGVDKVKSGTKYAFLMESTSIEFN 733
                  :.......:.:|.:|...:|....  .|||    |.|:.|||.| .|||:.::..:|:.
  Rat   688 YQHVRMKGLNPFERDSMYSQMWRMINRSNG--SENNVLESQAGIQKVKYG-NYAFVWDAAVLEYV 749

  Fly   734 TVR--ECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCS 796
            .:.  :|:...||:.:.::|||||:....||||.|::.:||||:.|.:..||:|||.:  .|.|.
  Rat   750 AINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPK--NGQCD 812

  Fly   797 AKSDDDGPSE---LGVDNLSGIYVVLVIGSIISIIISIL-CWCYFVYKKAKNYEVP 848
            ..|..|...:   |.:.:|:|::.:|..|.::|.:|::| .|    :.:.|...||
  Rat   813 LYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETW----WSRRKGSRVP 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	79/415 (19%)
		ANF_receptor	46..380	CDD:279440	72/387 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	125/392 (32%)
		Lig_chan	549..819	CDD:278489	93/284 (33%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		64/332 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	82/433 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	124/383 (32%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740