DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and grin2ab

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_009304490.1	Gene:	grin2ab / 570493	ZFINID:	ZDB-GENE-070424-223	Length:	1445	Species:	Danio rerio

Alignment Length:	880	Identity:	190/880 - (21%)
Similarity:	371/880 - (42%)	Gaps:	176/880 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGVPLVGETEQVAYGNSVQAFAQLCRLMQS 91
            |..|.|.:. ||:..|.||  ::.....:..|:::..:|::|     .:|.|....|:
Zfish    77 ELMSRQRLH-GLVYGDGTD--QEAVAQMLDFVSSQTSMPILG-----IHGGSAMTMAE------- 126

  Fly    92 GVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEW- 155
                                   ||           |:...|....|.:..|..:..|:.:::|
Zfish   127 -----------------------KD-----------SSSSFFQFGASLQQEALLMLAIMEEYDWH 157

  Fly   156 ------SRFIFCYESAEYLKI-LDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLR---RIRKSED 210
                  ::|....|....::: :||...|:.::..|        .|:|..:...|   ::::.:.
Zfish   158 VFSVVTTKFPGFQEFIATVRVTVDHSFVRWDLQSVV--------TLDGVGEPEDRAHVQLKRIQS 214

  Fly   211 SRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEE 275
            ..|::..|....|.::.:|:.:|:....:.:|:.:|.  |.:||.  ..||...|:...:.|:.:
Zfish   215 PVILLYCSKDEAALVMEEARSLGLTGAGFVWIVPSLT--TGNLEH--IPEAFPAGMISVTYDEWD 275

  Fly   276 VRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPD 340
            . .|..:|...:|          .|:...|..:.....|.:.|         .:|..:.:..:..
Zfish   276 Y-PLETRLQDAVG----------IISSAAAAMFREEGRIPDGT---------ASCYGQSEKPEVP 320

  Fly   341 GSTFRNYMRSLEIKEKTITGRIYFEGNVRKGFTFDVIELQTS-GLVKVGTWE-EGKDFEFQRPPQ 403
            .|..|.||..:.:..|   ...:.:...:......||.|.|. ...|:|.|| .....:|...|:
Zfish   321 PSALRRYMMGVNLGGK---DHSFMDDGYQVNPKLVVIVLNTEREWEKMGRWENHSLRLKFPVWPR 382

  Fly   404 AVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIG---NNQF------------------ 447
            ..:|.|:|    .::..:.::::..:|:. :|:.:|.|.|   .|..
Zfish   383 YNSFGDMD----ADENHLSIVTLEERPFV-IVDDVDILTGTCMRNSVPCRKHIKDNTTEGSYVKK 442

  Fly   448 --QGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNST-SGMLKEIVEGRADLAITDLTITSE 509
              :|:.:|::|::|..:.|.:......|  |...|..|:. :||:.|:|..:|.:|:..|||..|
Zfish   443 CCKGFCIDILKKIARNVKFTYDLYLVTN--GKHGKKINNVWNGMVGEVVYKKAVMAVGSLTINEE 505

  Fly   510 REEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGV-SLCFFIIGRLSP 573
            |.|.||||:||:..||::: |.......:..:|::|||:.||:.:.:..|.| ::..|:...:||
Zfish   506 RSEAIDFSVPFVETGISVM-VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVTAIAVFLFEFISP 569

  Fly   574 IEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIA-PKALSTRTISAIWWFFTLIMVSS 637
            :.::......::|.  ...|||..::|...|.:......:. |:..:::.|.::|.||.:|.::|
Zfish   570 LGFNRNLAQGKDPH--GPSFTIGKAVWLLWGLVFNNSVPVQNPRGTTSKFIVSVWAFFAVIFLAS 632

  Fly   638 YTANLAAFLTIENPTSPINSVKDLADNK--------DDVQYGAKRTGST-RNFFSTSEEPIYIKM 693
            ||||||||:..|   ..::.|..|:|.|        ...::|....||| ||....     |..|
Zfish   633 YTANLAAFMIQE---EFVDQVTGLSDRKFQSPYSYSPPFRFGTVPNGSTERNIRKN-----YPAM 689

  Fly   694 NEYLNAHPEMLMENNQQGV----DKVKSGTKYAFLMESTSIEFNTVRE--CNLTKVGDP--LDEK 750
            ::|       :::.:|.||    ..:|:|...||:.::..:.:...|:  |.|..:|..  ....
Zfish   690 HQY-------MVKYHQTGVVDALVSLKTGKLDAFIYDAAVLNYMAGRDDGCKLVTIGSGYIFATT 747

  Fly   751 GYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGI 815
            ||||||.|...::...:.|:|.:...|.:..|:.:|.    .|:|..:.::...|:|.|||::|:
Zfish   748 GYGIAMQKGSYWKRLVDLAILGIIGDGEMEELEAQWL----TGICHNEKNEVMSSQLDVDNMAGV 808

  Fly   816 YVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFC 850
            :.:|.....:|:|..:  |.:..|     :.:.:|
Zfish   809 FYMLAAAMALSLITFV--WEHLFY-----WRLRYC 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	63/374 (17%)
		ANF_receptor	46..380	CDD:279440	52/344 (15%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	105/413 (25%)
		Lig_chan	549..819	CDD:278489	73/288 (25%)
grin2ab	XP_009304490.1	PBP1_iGluR_NMDA_NR2	25..382	CDD:107373	67/388 (17%)
		ANF_receptor	48..358	CDD:279440	61/364 (17%)
		PBP2_iGluR_NMDA_Nr2	393..790	CDD:270436	107/421 (25%)
		Lig_chan	544..816	CDD:278489	74/292 (25%)
		NMDAR2_C	827..1445	CDD:287527	2/15 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840