DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and grin3ba

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	948	Identity:	198/948 - (20%)
Similarity:	365/948 - (38%)	Gaps:	234/948 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ASSGQSIRLGLI------------TDDATDRIRQT------FEHAISVVNNELGVPLVGETEQVA 74
            |..|.::|||.:            .:.|...:||:      :..::.|::.|   ||.|:.|.:
Zfish    38 ARIGHTVRLGALLPTRQQSRIQGALNRALVHLRQSGNNFLPYNLSLEVLSRE---PLNGDPESM- 98

  Fly    75 YGNSVQAFAQLCR-LMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPS 138
                   |..:|: ::..||.||..                      :|.              |
Zfish    99 -------FRCVCQDIVVQGVSAVLA----------------------FPQ--------------S 120

  Fly   139 PEDIANALYDIVNQFEWSRFIFCYESAEYLKILD--HL--MTRY---GIKGPVIKVMRYDLNLNG 196
            .|::...  :.::.|....||...|..|.||..:  ||  |||.   |:...::.|:     |.|
Zfish   121 HEELIQV--EFMSSFLEIPFISIIEQGEPLKTQNRFHLQMMTRMPPSGLSDLLLAVL-----LRG 178

  Fly   197 NYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFD--LEEYKYS 259
            .:        :...:.:...|..||:.|.|:|...:| ::..:.::...|||...:  :.|.|..
Zfish   179 GW--------QGGAATVCPGGGNTGMLEELQQRGHLG-LDGAHWHLWETLNLSRLEENISEDKVM 234

  Fly   260 E-----------ANITGIRMFSPDQEEVRDLMEKLHQELGESEPV--------------NSGST- 298
            |           |..:.:.:|..|.|....::...||..|...|:              :.||.
Zfish   235 ELLSQLLSRTPSAPASSVVLFGSDPECTATVLHCAHQLSGTLPPMHWIMGYPLSLDSLHSIGSPL 299

  Fly   299 ---------------FITMEMALTYDAVRVIAETTKHLPYQPQMLNCSE---RHDNVQPDGSTFR 345
                           :|...:.|...||.........|.....|:||.:   :|: :...|....
Zfish   300 GLMAYGEVNRKPLNFYIRDTLQLIGRAVYAATMVRPDLALIQNMVNCFDKPNKHE-LPSSGQYLA 363

  Fly   346 NYMRSLEIKEKTITGRIYFEGNVRKGFT---FDVIELQTSGL-----VKVGTWEEGK-DFEFQRP 401
            .::.:...  ..:||.:..|.:..:..|   |.:..||...|     |.|.:|:.|: :.|.|..
Zfish   364 RFLSNTSF--TGLTGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTVASWQSGRLELEEQGL 426

  Fly   402 PQAVNFNDIDDG-----------------------SLVNKTFIVLISVATK---PYASLVESIDT 440
            ...|..:..:||                       :||...|:....|..:   |...|  .:|.
Zfish   427 WPGVTQHQREDGPGIRLGGRWQAGLPVAGSRLRVVTLVEHPFVFTREVDEEGQCPAGQL--CLDP 489

  Fly   441 LIGNNQF------------------------QGYGVDLIKELADKLGFNF-TFRDGGNDYGSFNK 480
            ...|::.                        .||.:||:::||:.:.|.| .:..|...||::.
Zfish   490 QTNNSEVLNQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFEFDLYIVGDGKYGAWK- 553

  Fly   481 TTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDP 545
             ....||::.:::.|.||:|:|..:|.|.|..||||:.||.:..:.||......|.| :.:||.|
Zfish   554 -GGRWSGLVGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSLGILVRSKDTAAP-IGAFMWP 616

  Fly   546 FSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQG 610
            ....:|:.:.:| |.::..|..:     .||::|:............|:.:::|......|.  |
Zfish   617 LHWSMWVGIFVA-LHITALFITL-----YEWNSPFGMTPHGRNRIRVFSYSSALNLCYAILF--G 673

  Fly   611 SEIA---PKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDV--QY 670
            ..:|   ||..:.|.:..:|..|.|:::|||||||||.:..|.....::.:.|:..:...:  ::
Zfish   674 RTVASKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDVKLHHPSLGFRF 738

  Fly   671 GAKRTGSTRNFFSTSEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKY--AFLMESTSIEFN 733
            |..|..|..::...|    :.:|:||:....:   .....||..:|:....  ||:|:...:::.
Zfish   739 GTVRESSAEDYVKKS----FPEMHEYMRRFNK---PTTPDGVSTLKTDPPQLDAFIMDKALLDYE 796

  Fly   734 TV--RECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAG--V 794
            ..  .:|.|..||.|...:||||.:.:|.|.....::.:...:..|.:..|.:||:..|..|  |
Zfish   797 VSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTRNVSEYVSRYKSDGYMDMLHDKWYKVVPCGKRV 861

  Fly   795 CSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISIL 832
            .:...    ..::|:.:.||::|:|.:| :...::::|
Zfish   862 FAVTE----TLQMGIQHFSGLFVLLCVG-VAGALLTLL 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	82/442 (19%)
		ANF_receptor	46..380	CDD:279440	71/396 (18%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	97/407 (24%)
		Lig_chan	549..819	CDD:278489	64/280 (23%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	86/455 (19%)
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	98/414 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740