DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and grin2aa

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_021329529.1	Gene:	grin2aa / 563297	ZFINID:	ZDB-GENE-070424-129	Length:	1460	Species:	Danio rerio

Alignment Length:	954	Identity:	204/954 - (21%)
Similarity:	392/954 - (41%)	Gaps:	239/954 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LIILSLSRVQ--------AQFYGGNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGV 64
            |.::|:|...        |...|...|  .|.:.||.....||..|         ::||     .
Zfish    20 LTLISISHAAEKVPILNIAVILGQTRY--ISDRDIRALWSKDDPID---------VNVV-----T 68

  Fly    65 PLVGETEQVAYGNSVQAFAQLCRLMQSGV---GAVFGPAARHTA-SHLLNACDSKD-IPFIYPHL 124
            .||.||:..:      ....:|.|| ||.   |.|||......| :.:|:...|:. ||.:..|
Zfish    69 LLVNETDPKS------IITHVCDLM-SGTKIHGVVFGDGTDQEAIAQILDFISSQTLIPILGIH- 125

  Fly   125 SWGSNPDGFNLHPSPEDIANALY--------------DIVNQFEWSRFIFC------YESAEYLK 169
                  .|.::..:.:|:.:..:              :|:.:::|..|...      |:  :::.
Zfish   126 ------GGSSMIMADKDVKSTFFQFGASIQQEALLMLNIMEEYDWHVFSIVTSKFPGYQ--DFIA 182

  Fly   170 ILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGI 234
            ||...:....:...:..::..|. ::|:.::.: :::|.:...:::..|....|.:|.:|:.:|:
Zfish   183 ILKTTVDNSFVGWDLQHIITLDA-VDGDSRTQI-QLKKVQSPVVLLYCSKDEAAYILEEARSLGL 245

  Fly   235 MNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTF 299
            ....|.:|:.:|.                ||....:||                         ||
Zfish   246 TGFGYIWIVPSLT----------------TGNPEITPD-------------------------TF 269

  Fly   300 ITMEMALTYD-------------------AVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFR 345
            .:..::::||                   |...:.|....:|  ....:|..:.:..:...|...
Zfish   270 PSGMISVSYDDWDYPLEARVRDGLGIITTAAAAMLEEFGDIP--EAKTSCYGQMEKTKLPPSALH 332

  Fly   346 NYMRSLEIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLV----------KVGTWEEGKDFEFQR 400
            .||.::....|.::            ||.|..::....:|          |:|.| |.:....:.
Zfish   333 KYMMNVTWDGKDLS------------FTEDGYQVHPKLVVIVLNKDREWEKMGKW-ENQSLTLKY 384

  Fly   401 P--PQAVNFND--IDDGSLVNKTFIVLISVATKPYASLVESIDTLIG--------------NNQF 447
            |  |:..:|.|  .||..|      .::::..||:. :||:::.|.|              :|..
Zfish   385 PVWPRFNSFGDAETDDNHL------TIVTLEEKPFV-IVENVERLTGTCMRNSVPCRKHIKDNTT 442

  Fly   448 QGYG-----------VDLIKELADKLGFNFTFRDGGNDYGSFNKTTNST-SGMLKEIVEGRADLA 500
            :|.|           :|::|::|..:.|.:......|  |...|..|:. :||:.|:|..:|.:|
Zfish   443 EGGGTYIKKCCKGFCIDILKKIARNVKFTYDLYLVTN--GKHGKKINNVWNGMVGEVVNKKAVMA 505

  Fly   501 ITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGV-SLC 564
            :..|||..||.||||||:||:..||::: |.......:..:|::|||:.||:.:.:..|.| ::.
Zfish   506 VGSLTINEERSEVIDFSVPFVETGISVM-VSRSNGTVSPSAFLEPFSASVWVMMFVMLLLVTAMA 569

  Fly   565 FFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIA-PKALSTRTISAIWW 628
            .|:...:||:.::......::|.  ...||:..::|...|.:......:. ||..:::.|.::|.
Zfish   570 VFMFEYISPLGFNRNLAQGKDPH--GPSFTMGKAVWLLWGLVFNNSVPVQNPKGTTSKFIVSVWA 632

  Fly   629 FFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNK--------DDVQYGAKRTGST-RNFFST 684
            ||.:|.::|||||||||:..|   ..::.|..|:|.|        ...::|....||| ||....
Zfish   633 FFAVIFLASYTANLAAFMIQE---EFVDQVTGLSDKKFQSPYSYSPPFRFGTVPNGSTERNIRKN 694

  Fly   685 SEEPIYIKMNEYLNAHPEMLMENNQQGVD----KVKSGTKYAFLMESTSIEFNTVRE--CNLTKV 743
                 |..|::|       :::.:|.||:    .:|:|...||:.::..:.:...|:  |.|..:
Zfish   695 -----YPDMHQY-------MVKYHQTGVNDALVSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTI 747

  Fly   744 GDP--LDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSE 806
            |..  ....|||||:.|...::...:.|:|.:...|.:..|:.:|.    .|:|..:.::...|:
Zfish   748 GSGYIFATTGYGIALQKGSLWKRPVDLAILAIIGDGEMEELEAQWL----TGICHNEKNEVMSSQ 808

  Fly   807 LGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFC 850
            |.|||::|::.:|.....:|:|..:  |.:..|     :.:.:|
Zfish   809 LDVDNMAGVFYMLATAMGLSLITFV--WEHLFY-----WRLRYC 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	68/415 (16%)
		ANF_receptor	46..380	CDD:279440	59/377 (16%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	107/415 (26%)
		Lig_chan	549..819	CDD:278489	72/288 (25%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	74/445 (17%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	111/429 (26%)
		NMDAR2_C	836..1460	CDD:313729	2/15 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591274
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740