DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIID and Gria1

DIOPT Version :9

Sequence 1:NP_651982.1 Gene:GluRIID / 44483 FlyBaseID:FBgn0028422 Length:902 Species:Drosophila melanogaster
Sequence 2:NP_113796.1 Gene:Gria1 / 50592 RGDID:621531 Length:907 Species:Rattus norvegicus


Alignment Length:925 Identity:299/925 - (32%)
Similarity:485/925 - (52%) Gaps:96/925 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 GNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGVP--LVGETEQVAYGNSVQAFAQL 85
            |....|:...:|::|.:..:...:....|..|:|    :|..|  |:.:.:.|...:|.:...:.
  Rat    14 GAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALS----QLTEPPKLLPQIDIVNISDSFEMTYRF 74

  Fly    86 CRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIV 150
            |.....||.|:||...|.|.:.|.:.|.:..:.||.|.....:: :.|.|...|| :..||..|:
  Rat    75 CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTS-NQFVLQLRPE-LQEALISII 137

  Fly   151 NQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVV 215
            :.::|..|::.|::...|.:|..::.....|...:..:.........|:.:.:.:.|.::..:||
  Rat   138 DHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVV 202

  Fly   216 VGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLM 280
            ...:..:..:|.|..::......|.||:.||.....||.::|.|.||:||.::.:........:|
  Rat   203 DCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIM 267

  Fly   281 EKL-------HQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQ 338
            ::.       |..:....|..:.        |||||.|:|:||..:.|  :.|.::.|.|.:   
  Rat   268 QQWRTSDSRDHTRVDWKRPKYTS--------ALTYDGVKVMAEAFQSL--RRQRIDISRRGN--- 319

  Fly   339 PDGSTFRN----------YMRSL-EIKEKTITGRIYF-EGNVRKGFTFDVIELQTSGLVKVGTWE 391
             .|....|          ..|:| :::.:.:||.:.| |...|..:|..|||::..|:.|:|.|.
  Rat   320 -AGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWN 383

  Fly   392 EGKDFEFQRPPQAVNFN-DIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLI 455
            |...|    .|.|.:.. ..|:.|:.|:|:|| .::...||..|.::.:...||::::||.|:|.
  Rat   384 EDDKF----VPAATDAQAGGDNSSVQNRTYIV-TTILEDPYVMLKKNANQFEGNDRYEGYCVELA 443

  Fly   456 KELADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFS 517
            .|:|..:|:::...   ||  .||:.:..|.:.:||:.|:|.||||:|:..||||..||||||||
  Rat   444 AEIAKHVGYSYRLEIVSDG--KYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFS 506

  Fly   518 IPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPC 582
            .|||:|||:|:..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||.:    
  Rat   507 KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHS---- 567

  Fly   583 IEEPEE--------LENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYT 639
             ||.||        ..|:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||
  Rat   568 -EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYT 631

  Fly   640 ANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEM 703
            ||||||||:|...|||.|.:||| .:.::.||....|||:.||..|:..::.||..|: :|.|.:
  Rat   632 ANLAAFLTVERMVSPIESAEDLA-KQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSV 695

  Fly   704 LMENNQQGVDKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKF 766
            .:...::|:.:| ||..|||:|:|||..|:...|: |:..|||..||.||||||..|....|:..
  Rat   696 FVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPV 760

  Fly   767 NKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDD--DGPSELGVDNLSGIYVVLVIGSIISIII 829
            |.|:|:|.|||:|.:||||||.:  .|.|.:...|  |..|.|.:.|::|::.:|:.|..:::::
  Rat   761 NLAVLKLNEQGLLDKLKNKWWYD--KGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLV 823

  Fly   830 SILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFS-----------------ENERPL-----KS 872
            :::.:||....::|..: .||....:.....||.|                 ||.|.:     ||
  Rat   824 ALIEFCYKSRSESKRMK-GFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKS 887

  Fly   873 AQSIYSRSRNSSQSI 887
            .|||...|.:|...:
  Rat   888 MQSIPCMSHSSGMPL 902

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIIDNP_651982.1 PBP1_iGluR_Kainate 35..397 CDD:107377 88/382 (23%)
ANF_receptor 46..380 CDD:279440 82/354 (23%)
PBP2_iGluR_Kainate 417..788 CDD:270432 174/384 (45%)
Lig_chan 549..819 CDD:278489 124/282 (44%)
Gria1NP_113796.1 PBP1_iGluR_AMPA_GluR1 26..392 CDD:380613 90/389 (23%)
PBP2_iGluR_AMPA_GluR1 406..787 CDD:270447 176/391 (45%)
Glutamate binding. /evidence=ECO:0000250 492..494 0/1 (0%)