DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and grin2da

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	880	Identity:	195/880 - (22%)
Similarity:	356/880 - (40%)	Gaps:	234/880 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 ISVVNNELGVPLVGETEQVAYGNSVQAFAQLCRLMQSGVGAVFGPAARHTASHLLNACDSKDIPF 119
            :..|:.:.|||::.                      .|.||..|...:.:.|..|....|.|:..
Zfish   161 LEFVSAQTGVPVIA----------------------VGGGAGLGREPQESGSVYLQFSCSTDLQL 203

  Fly   120 IYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFC------YESAEYLKILDHLMTRY 178
                                    ..:::::.:|:|:.|...      ||  ::|.:::.:
Zfish   204 ------------------------EVIFEVLEEFDWTAFSVVTTRHHGYE--DFLAMVEGM---- 238

  Fly   179 GIKGPVIKVMRYD---LNLN---GNYKSVLRRIRKSEDSRIVVVGSTTGVAE-LLRQAQQVGIMN 236
             |.|..|...|..   |||.   |..::  ||:.|..::::.::..:...|| :.:.|...|...
Zfish   239 -IDGSFIGWERKSVVMLNLTDDPGGART--RRLLKENEAQVRLLYCSQEEAEQIFKAAWASGQAT 300

  Fly   237 EDYTYIIGNLNLHTFDLEEYKYSEANITGI--RMFSPDQEEVRDLMEKLHQELGESEP---VNSG 296
            ..:.:......|....||          |:  .:|:...:..||            ||   :..|
Zfish   301 PSHMWFAVGPGLSGLGLE----------GLPKALFAVRPQGWRD------------EPRRRIAKG 343

  Fly   297 STFIT---MEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEIKEKTI 358
            .:.:|   |.:...|...|..:..                 .|...||:           :.:.:
Zfish   344 VSVLTHGAMALRREYGGARGTSFA-----------------GNCMMDGN-----------QTQRV 380

  Fly   359 TGRIYFEGNVR---KGFTF-----------DVIELQTS-GLVKVGTWEEGKDFEFQRPP---QAV 405
            .|||.|..|:.   :.::|           |||..... |..:||.||.|. ...:.||   ...
Zfish   381 PGRIRFFSNITLSGRDYSFNNDGYLANPLLDVISYTAGRGWEEVGWWENGV-LRLRYPPWSRYGP 444

  Fly   406 NFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIG-------------NNQF---------- 447
            ....:||..     .:.::::..:|:. :||..|...|             ||..
Zfish   445 FLKPLDDSQ-----HLRVVTLEERPFV-IVEPADPGTGSCIRDSVPCRLPLNNSMVVEGIQSMKH 503

  Fly   448 --QGYGVDLIKELADKLGFNFTF------RDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDL 504
              :|:.:|::|.||..:||.:..      |.|.|..|.:|       ||:.|:|..|||:||..|
Zfish   504 CCKGFCIDVLKRLAKIVGFTYDLYLVTNGRHGKNIDGQWN-------GMVGEVVSKRADMAIGSL 561

  Fly   505 TITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLG-VSLCFFII 568
            ||..||.||::||:||:..||::: |.......:..:|::|:|..||:.:.:..|. |::..||.
Zfish   562 TINEERSEVVEFSVPFVETGISVM-VSRSNGTVSPSAFLEPYSPAVWVMMFVMCLSVVAVTVFIF 625

  Fly   569 GRLSPIEWDNPYPCIEEPEELE-------NQFTINNSLWFTTGALLQQGSEIA-PKALSTRTISA 625
            ...||:.::         ..|:       ::|||..|:|.....:......:. |:..:::.:..
Zfish   626 EFFSPVGYN---------RSLQSGKTAGGSKFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVL 681

  Fly   626 IWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNK---DDVQYGAKRTGSTRNFFSTSEE 687
            :|.||.:|.::|||||||||:..|   ..|::|..|:|.|   ...||...|.|:..|  .::||
Zfish   682 VWAFFAVIFLASYTANLAAFMIQE---EYIDTVSGLSDKKFQHPTEQYPPLRFGTVPN--GSTEE 741

  Fly   688 PIYIKMNEYLNAHPEMLMENNQQGV----DKVKSGTKYAFLMESTSIEFNTVRE--CNLTKVGD- 745
            .|   .:.|.|.| :.::.|||:||    :.:|:|...||:.::..:.:...::  |.:..:|.
Zfish   742 NI---RSNYPNMH-QYMVRNNQRGVEDAIENLKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSG 802

  Fly   746 -PLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGV 809
             .....|||:|:.||..::...:.|||:|.....:..|:..|.    :|:|.....:...|:|.:
Zfish   803 KVFATTGYGVALHKNSRWKRPLDLALLQLVGDDEIDMLERLWL----SGICHNDKIEVMSSKLDI 863

  Fly   810 DNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKN 844
            ||::|::.:|::...:|::  :..|.:.||.|.::
Zfish   864 DNMAGVFYMLLVAMGLSLL--VFAWEHLVYWKLRH 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	65/377 (17%)
		ANF_receptor	46..380	CDD:279440	59/359 (16%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	113/421 (27%)
		Lig_chan	549..819	CDD:278489	75/289 (26%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	67/385 (17%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	115/434 (26%)
		HisJ	<507..>590	CDD:223904	35/90 (39%)
		Lig_chan	605..877	CDD:278489	76/293 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740