DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and KaiR1D

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	837	Identity:	331/837 - (39%)
Similarity:	504/837 - (60%)	Gaps:	53/837 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRLGLITDDATDRIRQTFEHAISVVNNELGV----PLVGETEQVAYGNSVQAFAQLCRLMQSGVG 94
            |::|.:...|.|.....|..|:..:|.:..:    .||.:.|:::..:|..|..::|.|:..||.
  Fly    30 IKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQIERISPFDSFHAGKRVCGLLNIGVA 94

  Fly    95 AVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDG--FNLHPSPEDIANALYDIVNQFEWSR 157
            |:|||.:.|||||:.:.||:.:||.:.....:....:.  .||:|.|..::.|..|||..:.|..
  Fly    95 AIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKT 159

  Fly   158 FIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGV 222
            |...||:.:.:..|..|:..:|:....|.|.:  |:.:|:|:.:|::|:.|.::.||:..||..:
  Fly   160 FTIIYENNDGIVRLQELLKAHGMTPFPITVRQ--LSDSGDYRPLLKQIKNSAEAHIVLDCSTERI 222

  Fly   223 AELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQEL 287
            .|:|:||||:|:|::.::|::.:|:|||.:|:|::|...||||.|:.  :::.|.|::.:  ..:
  Fly   223 HEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNITGFRLI--NEKIVSDVVRQ--WSI 283

  Fly   288 GESEPVNSGS-TFITMEMALTYDAVRVIA------ETTKHLPYQPQMLNCSERHDNVQPDGSTFR 345
            .|...:.|.: |.:..|.||.||||.:.|      :|::.:...|  ::|..:  :....|.:..
  Fly   284 DEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHP--ISCDGQ--STWQHGFSLI 344

  Fly   346 NYMRSLEIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWE----EGKDF--EFQRPPQA 404
            |||:.:|:|..|...:...:| .|..|..|::||..:|:.|:|||.    :|.:|  .|.:..|.
  Fly   345 NYMKIVEMKGLTNVIKFDHQG-FRTDFMLDIVELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQE 408

  Fly   405 VNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFR 469
            :..|      |.||| :|:.::.:.||....||...|.||:||:||.||||.|::..||||:..:
  Fly   409 IEAN------LKNKT-LVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQ 466

  Fly   470 ---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVK 531
               ||  .|||.||.|...:||::|::|.||||||.|||||.|||:.:||:.||||||::|||.|
  Fly   467 LVPDG--SYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRK 529

  Fly   532 PQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTIN 596
            |.|.||.||||:.|.|.:||:|:..||||||:..||:.:.:|.||  |.......|::|:|||:.
  Fly   530 PIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW--PAYTDAHGEKVESQFTLL 592

  Fly   597 NSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDL 661
            |.:||..|:|:|||.:..|||||||.::.|||||||||:||||||||||||:|...|||.|.:||
  Fly   593 NCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDL 657

  Fly   662 ADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVDKVKSGT-KYAFL 724
            | .:..::|||.:.|||..||..|:...|.:|..:: :|.|.:...:|.:||::|..|. .||||
  Fly   658 A-KQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVERVAKGKGSYAFL 721

  Fly   725 MESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNE 789
            |||||||:.|.|.|.||:||..||.|.||||...|.|||...|..:|:|||:|.|..||.|||.|
  Fly   722 MESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEGKLHILKTKWWKE 786

  Fly   790 V-GAGVCSAKS--DDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAK 843
            . |.|.|..::  .....:|||:.|:.|::|||:.|..::.:|::   |.||:|..|
  Fly   787 KRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAV---CEFVWKSRK 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	112/380 (29%)
		ANF_receptor	46..380	CDD:279440	101/346 (29%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	194/375 (52%)
		Lig_chan	549..819	CDD:278489	133/274 (49%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	111/376 (30%)
		ANF_receptor	42..378	CDD:279440	101/346 (29%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	194/375 (52%)
		Lig_chan	547..823	CDD:278489	135/278 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.820