DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Ir93a

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	706	Identity:	155/706 - (21%)
Similarity:	288/706 - (40%)	Gaps:	153/706 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 IMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIR----MFSPDQ-EEVRD---LMEKLHQELGE- 289
            |::|..|..|..::|..:::.:....:.....:|    .|:|.: ||:|.   ::...|:::.|
  Fly   185 IVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEI 249

  Fly   290 SEPV------NSGSTFITMEMALTYDAVRV-------------IAETTKHLPYQPQMLNCSERHD 335
            :|.:      |....|:...:|..:||..|             :.||.   |.....|||:
  Fly   250 AETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDEGANIAFALNETD---PNCQDSLNCT---- 307

  Fly   336 NVQPDGSTFRNYMRSLEIKEKTITGRIYFEGNVRKGFT-----FDVIE-----LQTSG------- 383
             :........|.:..:.::|::|.|.|..|......||     .:::|     |:|:.
  Fly   308 -ISEISLALVNAISKITVEEESIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCAR 371

  Fly   384 --LVKVGTW---EEGKDFEF--QRPPQAVNFNDIDDG--------------------SLVNKTFI 421
              :....||   :|.:.|..  ||..:..||..|:.|                    ...|.|..
  Fly   372 WRVETAITWGKSQENRKFRSTPQRDAKNRNFEFINIGYWTPVLGFVCQELAFPHIEHHFRNITMD 436

  Fly   422 VLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFRD--------------GG 472
            :| :|...|:..|.::.:.:|  .:.:|..::::|||:..|.|::...:              ||
  Fly   437 IL-TVHNPPWQILTKNSNGVI--VEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGG 498

  Fly   473 ND----YGSFNKTTNSTSGMLKEIVEG-RADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKP 532
            |:    .||.   |......:.|:|:| :..:|....|:....::..:::.|......:.:..||
  Fly   499 NESDELVGSM---TFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKP 560

  Fly   533 QKAPPALFSFMDPFSSEVWLYL-GIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTIN 596
            .:. ..::.|..||:.|.|..| ||..| .:...:.|.||:|:          :...:....|:.
  Fly   561 DEV-SRIYLFTAPFTVETWFCLMGIILL-TAPTLYAINRLAPL----------KEMRIVGLSTVK 613

  Fly   597 NSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDL 661
            :..|:..|||||||....|.|.|.|.:...||...:::|::|..||.||||.......::.:..|
  Fly   614 SCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQL 678

  Fly   662 ADNKDDVQYGAKRTGSTRNFF-----STSEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKY 721
            .|:||.||||. |.|:   ||     ||:.|    ....||. ..::.....::.::.||.|.:.
  Fly   679 EDHKDIVQYGL-RNGT---FFERYVQSTTRE----DFKHYLE-RAKIYGSAQEEDIEAVKRGERI 734

  Fly   722 AF-----LMESTSIEFNTVRECNLTKVGDP-LDEKGYGIAMV--KNWPYRDKFNKALLELQEQGV 778
            ..     |.......|...:||:.....:. :||:   |||:  ....|....|:.:..:...|.
  Fly   735 NIDWRINLQLIVQRHFEREKECHFALGRESFVDEQ---IAMIVPAQSAYLHLVNRHIKSMFRMGF 796

  Fly   779 LARLKNKWWNEV---GAGVCSAKSDDDGPS--ELGVDNLSGIYVVLVIGSIISIII 829
            :.|     |:::   .||.|:.||.....:  ::.:|::.|.::||::|..::::|
  Fly   797 IER-----WHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLI 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	40/212 (19%)
		ANF_receptor	46..380	CDD:279440	35/183 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	96/403 (24%)
		Lig_chan	549..819	CDD:278489	74/288 (26%)
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	75/289 (26%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	74/287 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940