DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Ir85a

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_649833.1	Gene:	Ir85a / 41052	FlyBaseID:	FBgn0037630	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	95/525 - (18%)
Similarity:	176/525 - (33%)	Gaps:	152/525 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 WEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKP--YASLVESIDTLIGNNQFQGYGV 452
            |.:|:...::..|...|:               ||.|..||  ..:|.:.....|.|.|.:...:
  Fly   159 WRDGRLNAYRYNPFMDNY---------------LIPVDNKPNEVPTLEQLFPKTIPNMQRKPLRM 208

  Fly   453 DLIKELADKLGFNFTFRDGGNDYGSFNKTTNSTSGMLKEIVEGR--ADLAIT------------D 503
            .:.|   |.:...| :|.|         |...|.|:|...|..|  |.:.||            |
  Fly   209 CIYK---DDVRAIF-WRQG---------TILGTDGLLAAYVAERLNATMMITRPHSYNNHNLSSD 260

  Fly   504 LTITSEREEVIDFSIPFMNLGIAI--------------------LYVKPQKAPPALFSFMDPFSS 548
            :......:|.:|.:   ||:...:                    :.|...|..|..::....|.|
  Fly   261 ICFLEVAKEYVDVA---MNIRFLVPDTFRKQAESTVSHTRDDLCVIVPKAKTAPTFWNIFRSFGS 322

  Fly   549 EVWLYLGIAYLGVSL-CFFI---IGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQ 609
            .||..:.::.|..:: |:.:   :||:              |.:|            ..|||...
  Fly   323 LVWALILVSVLVANVFCYILKSEVGRV--------------PMQL------------FAGALTMP 361

  Fly   610 GSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKR 674
            .::|.|.. |.|.....|.:|.|::.|::..||.:.:..:.....||.:..||.:...:....:.
  Fly   362 MTQIPPNH-SIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRH 425

  Fly   675 TGSTRNFFSTS---EEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVR 736
            ....::|.:..   |..|..:|.|..:.....:|.||.         .::|:|.:.....|....
  Fly   426 VKHIQHFLTLGHKHESRIREQMLEVSDTQMYEMMRNND---------IRFAYLEKYHIARFQVNS 481

  Fly   737 ECNLTKVGDPLDE--------------KGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWW 787
            ..:: .:|.||..              ..||.      ||....:..:....|.|.     .::|
  Fly   482 RVHM-HLGRPLFHLMNSCLVPFHAVYIVPYGS------PYLGFLDSLIRSSHEFGF-----ERYW 534

  Fly   788 NEV--------GAGVCSAK--SDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKA 842
            :.:        |..|.:.:  |.:|.|..|.:.:...::.:.::|  |.:...:|.|.:..:
  Fly   535 DRIMNSAFIKSGVKVVNRRRGSGNDEPVVLKLQHFHAVFALWLVG--IGMACIVLAWEHLTH--- 594

  Fly   843 KNYEV 847
             ||.:
  Fly   595 -NYNL 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	2/6 (33%)
		ANF_receptor	46..380	CDD:279440
		PBP2_iGluR_Kainate	417..788	CDD:270432	78/427 (18%)
		Lig_chan	549..819	CDD:278489	52/300 (17%)
Ir85a	NP_649833.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740