DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and gria4a

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	901	Identity:	302/901 - (33%)
Similarity:	469/901 - (52%)	Gaps:	102/901 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EASSGQSIRLGLITDDATDRIRQTFEHAISVVN---NELGVP--LVGETEQVAYGNSVQAFAQLC 86
            |.:...|:::|.:....||:....|..||.:.|   |....|  ||...:.:...||.......|
Zfish    15 EGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIETANSFAVTNAFC 79

  Fly    87 RLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHL-SWGSNPDGFNLHPSPEDIANALYDIV 150
            .....||.|:||...:.:...|.:.|.:..|..:.|.. :.|.......|.||   |..||..::
Zfish    80 SQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLVTPSFPAEGETQFVLQLRPS---IRGALLSLL 141

  Fly   151 NQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVV 215
            :.::||||:|.|::.....:|..:|.:.|..|..:..:..:...:.:|:.:|..:.:.::.:.|:
Zfish   142 DHYDWSRFVFLYDTDRGYAVLQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQEKKFVI 206

  Fly   216 VGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLM 280
            ......:..:|.|...||...:.|.||:.||......||.:.:..||:||.::....:..|..||
Zfish   207 DLEAERLQNILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIKLM 271

  Fly   281 E---KLHQEL---GESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQP 339
            :   ||.|..   .||.|..:.|        ||||.|.|:||..::|  :.|.::.|.|.:
Zfish   272 QRWNKLDQREYPGSESPPRYTSS--------LTYDGVLVMAEAFRNL--RRQKIDISRRGN---- 322

  Fly   340 DGSTFRN----------YMRSL-EIKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEE 392
            .|....|          ..|:| :::.:.:||.|.|:...|: .:|.||.||:::|..|:|.|
Zfish   323 AGDCLANPAAPWNQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVFELKSNGPRKIGYW-- 385

  Fly   393 GKDFEFQRPPQAVNFNDID-------------DGSLVNKTFIVLISVATKPYASLVESIDTLIGN 444
                           ||:|             |.::.|:| :::.::...||..|.::.:...||
Zfish   386 ---------------NDLDKLVLVQNELSMGNDSAMENRT-VIVTTIMEGPYVMLKKNWEMYEGN 434

  Fly   445 NQFQGYGVDLIKELADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTI 506
            .||:||.|||..|:|..:|..:...   ||  .||:.:..|...:||:.|:|.|:|::|:..|.|
Zfish   435 EQFEGYCVDLASEVAKHIGIKYKISIVLDG--KYGARDPETKIWNGMVGELVYGKAEIAVAPLAI 497

  Fly   507 TSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRL 571
            |..||||||||.|||:|||:|:..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.
Zfish   498 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 562

  Fly   572 SPIEWDNPYPCIEEPEE---------LENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIW 627
            ||.||..     |||||         ..|:|.|.|||||:.||.:|||.:..|::||.|.:..:|
Zfish   563 SPYEWHT-----EEPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVW 622

  Fly   628 WFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIK 692
            ||||||::||||||||||||:|...|||.|.:||| .:.::.||...:|||:.||..|:..:|.|
Zfish   623 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA-KQTEIAYGTLDSGSTKEFFRRSKIAVYEK 686

  Fly   693 MNEYL-NAHPEMLMENNQQGVDKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGI 754
            |..|: :|.|.:..:...:||.:| ||..|||||:|||..|:...|: |:..|||..||.||||:
Zfish   687 MWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGV 751

  Fly   755 AMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAK---SDDDGPSELGVDNLSGIY 816
            |..|........|.|:|:|.|.|||.:||||||.:  .|.|..|   |.|.....|.:.|::|::
Zfish   752 ATPKGSQLGTPVNLAVLKLSEAGVLDKLKNKWWYD--KGECGPKDSGSKDKSSQALSLSNVAGVF 814

  Fly   817 VVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFS--ENERPL 870
            .:||.|..::::::::.:||....:||..::.|.:|:..:.|:.|..|  ||.|.|
Zfish   815 YILVGGLGLAMLVALVEFCYKSRAEAKKLKLTFSEAMRNKARLSITGSLGENGRVL 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	98/385 (25%)
		ANF_receptor	46..380	CDD:279440	90/357 (25%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	173/385 (45%)
		Lig_chan	549..819	CDD:278489	125/284 (44%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	101/403 (25%)
		ANF_receptor	34..375	CDD:279440	90/357 (25%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	175/392 (45%)
		Lig_chan	540..821	CDD:278489	127/288 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591302
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850