DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and gria1b

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	855	Identity:	280/855 - (32%)
Similarity:	463/855 - (54%)	Gaps:	83/855 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GLITDDATDRIRQTFEHAISVVNNELGVP-LVGETEQVAYGNSVQAFAQLCRLMQSGVGAVFGPA 100
            ||...|:.:  ...|..|:|..|:   || ||.:.:.|..|:|.......|.....||.|:.|..
Zfish    29 GLFPTDSHE--YDVFRFALSQHND---VPKLVPQVDMVDTGSSFAMTYAFCSQFSKGVYAIIGLY 88

  Fly   101 ARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESA 165
            .|.|.:.|::.|.:..:.|:.|.....:| :.|.:...|| :.:||..:|..::|::|::.|.|.
Zfish    89 DRKTMNMLMSFCGALHVCFVTPSFPIDTN-NQFVIQLRPE-LQDALIALVEHYKWNKFVYMYSSD 151

  Fly   166 EYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLR--Q 228
            ..|.:|..::.....|...:..:.:|......:...::.:...::.:|::......:..:|.  .
Zfish   152 SGLTVLQKILDTAAEKTWQVTSINFDTLTEAAFLKAIQDLDNKKEFKIILDCELERLNSILNLIA 216

  Fly   229 AQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMF---SPD-QEEVRDLMEKLHQELGE 289
            ||:..:.|  |.||:.||.....:|.|::...||:||.::.   :|. ...::|.:|      .:
Zfish   217 AQKKNLKN--YHYILANLGFLDLNLTEFRKGGANVTGFQLMNYTNPTVSRTIQDWLE------FD 273

  Fly   290 SEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQ-------PDGSTFRNY 347
            |:.:.|....:....|||||.|.|:|...::|  :.|.::.|.|.:..:       |.|... :.
Zfish   274 SKDLKSPKRRLKYTGALTYDGVTVMATAFQNL--RKQRIDISRRGNAGECLANPPAPWGQGI-DI 335

  Fly   348 MRSL-EIKEKTITGRIYF--EGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVNFND 409
            .|:| :::.:.:||.:.|  :|: |..||..|:|...||..|||.|.:.:.:    ...|...|.
Zfish   336 QRALQQVQFEGLTGHVQFNDKGH-RTNFTVSVMEFGPSGPKKVGYWNQREKY----VSTATYSNM 395

  Fly   410 IDDG-SLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFR-DGG 472
            :::. .|.|:|::| .::...||..|.::.:.|:||::::||.|:|..|:|..:|:::... .|.
Zfish   396 LNETFGLQNRTYVV-TTILEAPYVMLKKNHEQLVGNDKYEGYCVELAAEIAKHVGYSYRLELVGD 459

  Fly   473 NDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPP 537
            ..||:.:..|...:||:.|:|.|:||:|:..||||..||||||||.|||:|||:|:..||.|:.|
Zfish   460 GKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSKP 524

  Fly   538 ALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEW------------DNPYPCIEEPEELE 590
            .:|||:||.:.|:|:.:..||:|||:..|::.|.||.||            :...|...||.:..
Zfish   525 GVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADDEEETADQQNQNQPPSPEPNQSP 589

  Fly   591 NQ------------------FTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSS 637
            ||                  |.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||
Zfish   590 NQSQNQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISS 654

  Fly   638 YTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHP 701
            ||||||||||:|...|||.|.:||| .:.::.||....|||:.||..|:..::.||..|: :|.|
Zfish   655 YTANLAAFLTVERMVSPIESAEDLA-KQTEIAYGTLDGGSTKEFFRRSKIAVFEKMWSYMKSAEP 718

  Fly   702 EMLMENNQQGVDKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRD 764
            .:.::...:||.:| ||..|||:|:|||..|:...|: |:..|||..||.||||:|..|....|:
Zfish   719 TVFVKTTDEGVVRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRN 783

  Fly   765 KFNKALLELQEQGVLARLKNKWW---NEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIIS 826
            ..|.|:|:|.|||:|.:||||||   .|.|:|...:|   |..|.|.:.|::|::.:|:.|..::
Zfish   784 PVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSK---DKTSALSLSNVAGVFYILIGGLGLA 845

  Fly   827 IIISILCWCY 836
            ::::::.:||
Zfish   846 MLVALVEFCY 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	92/376 (24%)
		ANF_receptor	46..380	CDD:279440	83/350 (24%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	172/407 (42%)
		Lig_chan	549..819	CDD:278489	125/305 (41%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	92/380 (24%)
		ANF_receptor	41..368	CDD:279440	82/343 (24%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	172/409 (42%)
		Lig_chan	536..842	CDD:278489	126/309 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750