DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIID and Ir64a

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	101/537 - (18%)
Similarity:	179/537 - (33%)	Gaps:	183/537 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 IDTLIGNNQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTN-------STSGMLKEIVEG 495
            |||:   |:|   ..:|:..:.|.  ||:||        ..::||:       ...||:..::..
  Fly   339 IDTM---NRF---NFNLLMAVRDM--FNWTF--------VLSRTTSWGYVKNGRFDGMIGALIRN 387

  Fly   496 RADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLG 560
            ..|:....:....||.:.||.:....:.....::..|:........|:.||:::||:.  |...|
  Fly   388 ETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWIL--IVGCG 450

  Fly   561 VSLCFFIIGRLSPIEWD-----------------------------------NPYPCI------- 583
            | |..||:..|:.|||.                                   .|...:
  Fly   451 V-LTVFILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKE 514

  Fly   584 ---EEPEELENQFTIN-NSLW---------------------------------FTTGALLQQGS 611
               |:.||.|:...|: .:||                                 |..|.:.|||.
  Fly   515 KVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGL 579

  Fly   612 EIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNK-----DDVQYG 671
            ..:...:|.|.|......|:..:...|:|::...|.:|.|.: |.::.||..:.     :|:.|
  Fly   580 GFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKT-IKTLSDLVHSSLKVGMEDILY- 642

  Fly   672 AKRTGSTRNFFSTSEEPIYI-------------KMNEYLNAHPEMLMENNQQGVDKVKS------ 717
                  .|::|..:::|:.:             |.||   |..:..::.|....|..||
  Fly   643 ------NRDYFLHTKDPVSMELYAKKITSVPTTKENE---ADEDEPVDPNPVSTDPAKSYRDIVH 698

  Fly   718 -----------------------------------GTKYAFLMESTSIEFNTVRECNLTKVGDPL 747
                                               ...|..:.|:    |:....|:||:|....
  Fly   699 SHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAET----FSEQDICDLTEVSMFP 759

  Fly   748 DEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNL 812
            .:|...| |.||.|.|...:..|..:.|.|:|....|.|.:.....|...::.|   ..:.:|.:
  Fly   760 PQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNVWHSRKPPCVKKIETSD---LHVDMDTV 820

  Fly   813 SGIYVVLVIGSIISIII 829
            |...::|:....|:::|
  Fly   821 SSALLILLFSYAITLMI 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377
		ANF_receptor	46..380	CDD:279440
		PBP2_iGluR_Kainate	417..788	CDD:270432	94/494 (19%)
		Lig_chan	549..819	CDD:278489	74/407 (18%)
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	28/126 (22%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	54/283 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840