DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Ir60a

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster

Alignment Length:	711	Identity:	125/711 - (17%)
Similarity:	239/711 - (33%)	Gaps:	199/711 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 YLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSE----DSRIVVVGSTTGVAELLR 227
            :.|:::..:|.   .||..:...:.:.:..:|........|.|    |:.::||.|...:.||::
  Fly    97 FSKLINEAVTN---PGPPDREELFQMRVASDYNITNGTEDKGELILADNYVIVVDSVDRLKELMK 158

  Fly   228 QAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEP 292
            :                                 .|..:|.::|...    .:...|.....:.|
  Fly   159 K---------------------------------KIVEMRSWNPGAR----FLVLFHNATCRNRP 186

  Fly   293 VNSGSTFI--TMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEIKE 355
            :...|...  .|||...:....:.|.:|                          .||
  Fly   187 LGVASNIFKDLMEMFYVHRVALLYANST--------------------------MNY-------- 217

  Fly   356 KTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAV---NFNDIDDG-SLV 416
            ..:....|...|.|      ::.:|:     ||...:||.:    |..||   :..|...| |..
  Fly   218 NLLVNDYYSNVNCR------ILNVQS-----VGQCHDGKLY----PNNAVVKASMQDYVSGFSPR 267

  Fly   417 NKTFIVLISVATKPYASLVESIDTLIG-NNQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNK 480
            |.||....|::    |..||: |.::| ..:..|:       :.::|.|:..........|..:.
  Fly   268 NCTFFACSSIS----APFVEA-DCILGLEMRILGF-------MKNRLKFDVNQTCSLESRGEMDG 320

  Fly   481 TTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDP 545
            ..|.| |:|.::.....|.........:|..:....|..::. .....|:|.....||..:.:..
  Fly   321 PANWT-GLLGKVQNNECDFVFGGYYPDNEVADHFWGSDTYLQ-DAHTWYIKMADRRPAWQALVGI 383

  Fly   546 FSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELEN-QFTINNSLWFTTGALLQQ 609
            |.:..|           :.|.:|..:|.:.|......:.||:..:. ..|..|:|..|....:|:
  Fly   384 FEAYTW-----------IGFILILIISWLFWFTLVMILPEPKYYQQLSLTAINALAVTISIAVQE 437

  Fly   610 GSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKR 674
                .|...:||........:.|.:|::||:.:.|  |.::|    ..:..|.:..:.|..|...
  Fly   438 ----RPICETTRLFFMALTLYGLNVVATYTSKMIA--TFQDP----GYLHQLDELTEVVAAGIPF 492

  Fly   675 TG--STRNFFSTSEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRE 737
            .|  .:|::|. :::.::| .|.| |..||.:.::  :.::.||.|                 :.
  Fly   493 GGHEESRDWFE-NDDDMWI-FNGY-NISPEFIPQS--KNLEAVKWG-----------------QR 535

  Fly   738 CNLTK----VGDPLDEKGYG-----------IAMVKNWPYRDKFNKALLELQEQGVLA------R 781
            |.|:.    :..||.:..|.           :.|...:|:..:.|..:..:::.|:..      |
  Fly   536 CILSNRMYTMQSPLADVIYAFPNNVFSSPVQMIMKAGFPFLFEMNSIIRLMRDVGIFQKIDADFR 600

  Fly   782 LKNKWWNEVGAGVCSAKSDDDGPSE---LGVDNLSGIYVVLVIGSIISIIISILCWCYFVY 839
            ..|.:.|.:.      |.....|..   |..::|.|.:.:||:||         ||....:
  Fly   601 YNNTYLNRIN------KMRPQFPETAIVLTTEHLKGPFFILVVGS---------CWAALTF 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	34/235 (14%)
		ANF_receptor	46..380	CDD:279440	29/218 (13%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	73/395 (18%)
		Lig_chan	549..819	CDD:278489	54/296 (18%)
Ir60a	NP_611901.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462830
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740