DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and gria3b

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	861	Identity:	283/861 - (32%)
Similarity:	457/861 - (53%)	Gaps:	76/861 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRLGLITDDATDRIRQTFEHAISVVN-----NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSGV 93
            |.:|.:...:|.:....|..|:.:.|     .|....|....:.:...||.......|.....||
Zfish    24 INIGGLFMRSTVQEHSAFRFAVQLYNTNQNMTEKPFHLNYNVDNLESSNSFSVTHAFCSQFSRGV 88

  Fly    94 GAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRF 158
            .|:||...:.:.:.|.:.|.:....|:.|.....|:.. |.:...| .:..|:..:::.::|.:|
Zfish    89 YAIFGFYDKKSMNTLTSFCGALHTSFVTPSYPIDSDVQ-FVIQMRP-PLKGAVLSLLSHYKWDKF 151

  Fly   159 IFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGN------YKSVLRRIRKSEDSRIVVVG 217
            ::.|::.....||..:|     :..|....:......|:      ::.::..:.:.::.|.::..
Zfish   152 VYLYDTDRGFSILQAIM-----EAAVANNWQVTARSVGSITDPQEFRRIIEEMDRRQEKRYLIDC 211

  Fly   218 STTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEK 282
            ....:..:|.|...:|..:..|.|||.||......|::.....|||:|.::.:|:...|:..:::
Zfish   212 EVDRINVILEQVVTLGKNSRGYHYIIANLGFTNISLDKVFLGGANISGFQIINPENLVVQQFLQR 276

  Fly   283 LHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHD------NVQPDG 341
             ...|.|.|...:.:|.:....||:|||:.||||..::|  :.|.::.|.|..      |.....
Zfish   277 -WDRLDEREFPEAKNTPLKYTSALSYDAILVIAEAFRYL--RRQRVDVSRRGSAGDCLANPAVPW 338

  Fly   342 STFRNYMRSLE-IKEKTITGRIYFEG-NVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQA 404
            |...:..|:|: ::.:.:||.|.|:. ..|..:|.||.|::|.|..|:|.|.|.:.|
Zfish   339 SQGIDIERALKMVQVQGMTGNIQFDSFGRRTNYTIDVYEMKTGGPRKIGYWNEFERF-------- 395

  Fly   405 VNFND---IDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNF 466
            ||..|   .:|.|.|....||:.::...||....::...|.||.:::||.|||..|:|..:|..:
Zfish   396 VNIMDQQFTNDSSSVENRTIVVTTIMEAPYVMYKKNHMHLEGNEKYEGYCVDLASEIAKHVGIKY 460

  Fly   467 TF---RDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAIL 528
            ..   .||  .||:.:..|.|.:||:.|:|.||||:|:..||||..||||||||.|||:|||:|:
Zfish   461 RLSIVMDG--KYGARDPETKSWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIM 523

  Fly   529 YVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELE--- 590
            ..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||.     ::|.:|::
Zfish   524 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWQ-----LDETDEVKDPQ 583

  Fly   591 ------NQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIE 649
                  |.|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||:|
Zfish   584 TPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVE 648

  Fly   650 NPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVD 713
            ...|||.|.:||| .:.::.||...:|||:.||..|:..:|.||..|: :|.|.:..:....||.
Zfish   649 RMVSPIESAEDLA-KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFAKTTPDGVA 712

  Fly   714 KV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQ 776
            :| ||..|:|||:|||..|:...|: |:..|||..||.||||:|..|....|:..|.|:|:|.||
Zfish   713 RVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQ 777

  Fly   777 GVLARLKNKWWNEVGAGVCSAKSDD--DGPSELGVDNLSGIYVVLVIGSIISIIISILCWCY--- 836
            |:|.:||||||.:  .|.|.:...|  |..|.|.:.|::|::.:||.|..::::::::.:||
Zfish   778 GLLDKLKNKWWYD--KGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR 840

  Fly   837 ------FVYKKAKNYE 846
                  .:.|.|:||:
Zfish   841 AEAKRLKLEKNAQNYK 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	84/380 (22%)
		ANF_receptor	46..380	CDD:279440	76/352 (22%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	173/385 (45%)
		Lig_chan	549..819	CDD:278489	123/283 (43%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	85/388 (22%)
		ANF_receptor	36..379	CDD:279440	76/352 (22%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	175/391 (45%)
		Lig_chan	544..824	CDD:278489	125/287 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591343
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750