DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and clumsy

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	947	Identity:	325/947 - (34%)
Similarity:	510/947 - (53%)	Gaps:	92/947 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HFCWISLIILS-LSRVQAQFYGGNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGVP 65
            ||..|:|.:|: :.|  :||..|:.:.:..          |::....|...:.|..:..|...||
  Fly     8 HFLLIALPVLADIDR--SQFMVGSIFTSDK----------DESEIAFRTAVDRANILERNVELVP 60

  Fly    66 LVGETEQVAYGNSVQAF---AQLCRLMQSGVGAVFGPAARHTASHLLNACDSKDIP-FIYPHLSW 126
            :      |.|.|:..:|   ..:|.|:..||.|:|||:...::..:.:.||:.||| .:|..:..
  Fly    61 I------VVYANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPN 119

  Fly   127 GSNPD------GFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKIL-DHLMTRYGIKGP- 183
            .|.||      ..|:||....::..|.:||..|.|..|...||:.:.|:.| |.|.....|..|
  Fly   120 ESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPT 184

  Fly   184 VIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNL 248
            .:|    .|....:::..|:.|:.|.|:.:::..:...:.::|:||.::.::.|..:..|..|:.
  Fly   185 TVK----QLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDT 245

  Fly   249 HTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQ-ELGESEPVNSGSTFITMEMALTYDAVR 312
            |:.|..|....|||||.:|:..|....|::::....: |..|..........:..:|.|..|||.
  Fly   246 HSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVW 310

  Fly   313 VIAETTKHLPYQPQM----LNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYF-EGNVRKGF 372
            :.::....|....::    |.|  |.....|.|.....::::.  .|:|.||||.| |...|..|
  Fly   311 LFSKGLTELGIFEELTAPDLEC--RRKKPWPFGKRIIEFIKAR--SEETSTGRIDFNENGQRSFF 371

  Fly   373 TFDVIELQTSGLVKVGTWE--EGKDFEFQRPPQAVNFNDIDDG------SLVNKTFIVLISVATK 429
            |...:||.:.|.:.:.||:  .|.|.          .||.::.      .|.||||||...:..
  Fly   372 TLRFMELNSDGFLDLATWDPVNGLDV----------LNDDEESEKRVGQKLSNKTFIVSSRLGA- 425

  Fly   430 PYASLVE--SIDTLIGNNQFQGYGVDLIKELADKLGFNFTFR---DGGNDYGSFNKTTNSTSGML 489
            |:.:|.|  ..:.|.||::::||.:|||.|:|..|.|.|.||   ||  .||:.||.|.:..|::
  Fly   426 PFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDG--KYGALNKVTQTWDGIV 488

  Fly   490 KEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYL 554
            :::::|.|||.|.|||:||.|.:.:||:.|||.|||:||:.||...|..||||:.|||.:||:|:
  Fly   489 RQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYM 553

  Fly   555 GIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALS 619
            |.|||.:||..|.:.|::|.:|:||:|| :||||:||.::|.|:.|.:.|:|:.||.:|.|||.|
  Fly   554 GSAYLFISLLLFALARMAPDDWENPHPC-KEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAAS 617

  Fly   620 TRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFST 684
            ||.::.:||||.|:|::|||||||||||.....:.|||.:||| .:..::|||...|||..||..
  Fly   618 TRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLA-AQSKIKYGAMAGGSTMGFFRD 681

  Fly   685 SEEPIYIKM-NEYLNAHPEMLMENNQQGVDKVKSGTK-YAFLMESTSIEFNTVRECNLTKVGDPL 747
            |....|.|| ....:|.|.:..:.|.:||::|:.|.. ||||||||::|:|..|:|:|.::|..|
  Fly   682 SNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWL 746

  Fly   748 DEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEV-GAGVCSAKSDDDG--PSELGV 809
            |.|.|||||..|.|||.:.:.|:|:|.|.|.||.||.|||.|: |.|.|. |||:||  ..|||:
  Fly   747 DYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCE-KSDEDGGDTPELGL 810

  Fly   810 DNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPL---- 870
            :|:.|:::||.:|.:.::::....:.:.|...|...::...:|...|.....|.....:|:
  Fly   811 ENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSS 875

  Fly   871 -----KSAQSIYSRSRNS--SQ--SIESLKTDSEENM 898
                 .|:.|..|||::|  ||  |::|||:...:::
  Fly   876 ESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDV 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	98/381 (26%)
		ANF_receptor	46..380	CDD:279440	91/351 (26%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	179/377 (47%)
		Lig_chan	549..819	CDD:278489	131/274 (48%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	98/393 (25%)
		ANF_receptor	39..379	CDD:279440	91/353 (26%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	179/377 (47%)
		Lig_chan	548..812	CDD:278489	129/266 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462601
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.750