DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and gria4b

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	911	Identity:	304/911 - (33%)
Similarity:	477/911 - (52%)	Gaps:	90/911 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SIRLGLITDDATDRIRQTFEHAISVVN-----NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSG 92
            |:::|.:....||:....|..||.:.|     :|....||...:.:...||.......|.....|
Zfish    26 SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRG 90

  Fly    93 VGAVFGPAARHTASHLLNACDSKDIPFIYPHL-SWGSNPDGFNLHPSPEDIANALYDIVNQFEWS 156
            |.|:||...:.:...|.:.|.:..|..|.|.. :.|.:.....|.||   |..||..:::.::|:
Zfish    91 VFAIFGLYDKRSVHTLTSFCGALHISLITPSFPTEGESQFVLQLRPS---IRGALLSLLDHYDWN 152

  Fly   157 RFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTG 221
            ||:|.|::.....||..:|.:.|..|..:..:..:...:.:|:.:|..:.:.::...|:......
Zfish   153 RFVFLYDTDRGYSILQAIMEKAGQNGWQVSAICVENFNDASYRQLLEDLDRRQEKTFVIDLEAER 217

  Fly   222 VAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLME---KL 283
            :..:|.|...||...:.|.||:.||.....:||.:.:..||:||.::.......|..||:   ||
Zfish   218 LNNMLEQIVSVGKHVKGYHYIMANLGFKDINLERFMHGGANVTGFQLVDFSNPMVIKLMQRWNKL 282

  Fly   284 HQE--LGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPD------ 340
            .|.  .|...|....|       |||||.|.|:||..::|  :.|.::.|.|  .:..|
Zfish   283 DQREYPGSDAPPKYTS-------ALTYDGVMVMAEAFRNL--RRQKVDISRR--GIAGDCLANPA 336

  Fly   341 -----GSTFRNYMRSLEIKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEEGKDFEFQ 399
                 |......::.:.:  :.:||.:.|:...|: .:|.||.||:::|..::|.|.:.......
Zfish   337 APWNQGIDMERTLKQVHL--QGLTGNVQFDHYGRRVNYTMDVFELKSNGPRRIGYWNDADKLVLT 399

  Fly   400 RPPQAVNFNDIDDGSLVNKT------FIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKEL 458
            :          |...|.|:|      .:::.::...||..|.::.:...||.|::||.|||..|:
Zfish   400 Q----------DHALLPNETSGMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQYEGYCVDLASEI 454

  Fly   459 ADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPF 520
            |..:||.:...   ||  .||:.:..|...:||:.|:|.|:|::|:..||||..||||||||.||
Zfish   455 AKHIGFKYKISIVPDG--KYGARDPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPF 517

  Fly   521 MNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEE 585
            |:|||:|:..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||..     ||
Zfish   518 MSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EE 577

  Fly   586 PEE---------LENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTAN 641
            |||         ..|:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||
Zfish   578 PEEGTDGLPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTAN 642

  Fly   642 LAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLM 705
            ||||||:|...|||.|.:||| .:.|:.||...:|||:.||..|:..:|.||..|: :|.|.:..
Zfish   643 LAAFLTVERMVSPIESAEDLA-KQTDIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFT 706

  Fly   706 ENNQQGVDKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNK 768
            :...:||.:| ||..|||||:|||..|:...|: |:..|||..||.||||:|..|....|...|.
Zfish   707 KTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVNL 771

  Fly   769 ALLELQEQGVLARLKNKWW---NEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIIS 830
            |:|:|.|||:|.:||||||   .|.|:|....|  |.....|.:.|::|::.:||.|..::::::
Zfish   772 AVLKLNEQGLLDKLKNKWWYDKGECGSGGGGEK--DKSSQALSLSNVAGVFYILVGGLGLAMLVA 834

  Fly   831 ILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFS--ENERPL-----KSAQSIYSRSRNSSQSIE 888
            ::.:||....:||..::.|.:|:..:.|:.|..|  ||.|.|     |:..|..|..::|..::.
Zfish   835 LIEFCYKSRNEAKRMKLTFTEAMRNKARLSITGSVGENGRVLTPDCPKAVHSGPSLRQSSGLALV 899

  Fly   889 S 889
            |
Zfish   900 S 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	94/384 (24%)
		ANF_receptor	46..380	CDD:279440	87/356 (24%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	178/394 (45%)
		Lig_chan	549..819	CDD:278489	128/284 (45%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	94/385 (24%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	176/386 (46%)
		Lig_chan	546..827	CDD:306551	130/288 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750