Protein Alignment GluRIID and gria4b

DIOPT Version :10

• Sequence 1: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: NP_997917.2
• Gene: gria4b / 336069
• ZFINID: ZDB-GENE-030131-8013
• Length: 904
• Species: Danio rerio
• Alignment Length: 911
• Identity: 304/911 - (33%)
• Similarity: 477/911 - (52%)
• Gaps: 90/911 - (9%)

  Fly    33 SIRLGLITDDATDRIRQTFEHAISVVN-----NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSG 92
            |:::|.:....||:....|..||.:.|     :|....||...:.:...||.......|.....|
Zfish    26 SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRG 90

  Fly    93 VGAVFGPAARHTASHLLNACDSKDIPFIYPHL-SWGSNPDGFNLHPSPEDIANALYDIVNQFEWS 156
            |.|:||...:.:...|.:.|.:..|..|.|.. :.|.:.....|.||   |..||..:::.::|:
Zfish    91 VFAIFGLYDKRSVHTLTSFCGALHISLITPSFPTEGESQFVLQLRPS---IRGALLSLLDHYDWN 152

  Fly   157 RFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTG 221
            ||:|.|::.....||..:|.:.|..|..:..:..:...:.:|:.:|..:.:.::...|:......
Zfish   153 RFVFLYDTDRGYSILQAIMEKAGQNGWQVSAICVENFNDASYRQLLEDLDRRQEKTFVIDLEAER 217

  Fly   222 VAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLME---KL 283
            :..:|.|...||...:.|.||:.||.....:||.:.:..||:||.::.......|..||:   ||
Zfish   218 LNNMLEQIVSVGKHVKGYHYIMANLGFKDINLERFMHGGANVTGFQLVDFSNPMVIKLMQRWNKL 282

  Fly   284 HQE--LGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPD------ 340
            .|.  .|...|....|       |||||.|.|:||..::|  :.|.::.|.|  .:..|
Zfish   283 DQREYPGSDAPPKYTS-------ALTYDGVMVMAEAFRNL--RRQKVDISRR--GIAGDCLANPA 336

  Fly   341 -----GSTFRNYMRSLEIKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEEGKDFEFQ 399
                 |......::.:.:  :.:||.:.|:...|: .:|.||.||:::|..::|.|.:.......
Zfish   337 APWNQGIDMERTLKQVHL--QGLTGNVQFDHYGRRVNYTMDVFELKSNGPRRIGYWNDADKLVLT 399

  Fly   400 RPPQAVNFNDIDDGSLVNKT------FIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKEL 458
            :          |...|.|:|      .:::.::...||..|.::.:...||.|::||.|||..|:
Zfish   400 Q----------DHALLPNETSGMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQYEGYCVDLASEI 454

  Fly   459 ADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPF 520
            |..:||.:...   ||  .||:.:..|...:||:.|:|.|:|::|:..||||..||||||||.||
Zfish   455 AKHIGFKYKISIVPDG--KYGARDPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPF 517

  Fly   521 MNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEE 585
            |:|||:|:..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||..     ||
Zfish   518 MSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EE 577

  Fly   586 PEE---------LENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTAN 641
            |||         ..|:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||
Zfish   578 PEEGTDGLPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTAN 642

  Fly   642 LAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLM 705
            ||||||:|...|||.|.:||| .:.|:.||...:|||:.||..|:..:|.||..|: :|.|.:..
Zfish   643 LAAFLTVERMVSPIESAEDLA-KQTDIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFT 706

  Fly   706 ENNQQGVDKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNK 768
            :...:||.:| ||..|||||:|||..|:...|: |:..|||..||.||||:|..|....|...|.
Zfish   707 KTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVNL 771

  Fly   769 ALLELQEQGVLARLKNKWW---NEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIIS 830
            |:|:|.|||:|.:||||||   .|.|:|....|  |.....|.:.|::|::.:||.|..::::::
Zfish   772 AVLKLNEQGLLDKLKNKWWYDKGECGSGGGGEK--DKSSQALSLSNVAGVFYILVGGLGLAMLVA 834

  Fly   831 ILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFS--ENERPL-----KSAQSIYSRSRNSSQSIE 888
            ::.:||....:||..::.|.:|:..:.|:.|..|  ||.|.|     |:..|..|..::|..::.
Zfish   835 LIEFCYKSRNEAKRMKLTFTEAMRNKARLSITGSVGENGRVLTPDCPKAVHSGPSLRQSSGLALV 899

  Fly   889 S 889
            |
Zfish   900 S 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..400	CDD:380605	94/387 (24%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	178/394 (45%)
		Lig_chan	547..819	CDD:459656	128/286 (45%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_type1	28..400	CDD:471960	94/387 (24%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	176/386 (46%)
		Lig_chan	546..826	CDD:459656	130/287 (45%)