DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Ir8a

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	939	Identity:	222/939 - (23%)
Similarity:	378/939 - (40%)	Gaps:	225/939 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WISLIILSLSRVQAQFYGGNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGVPLVGE 69
            ||..:      .:|:|....|.......::||.:..||.|          :::..:|.|:
  Fly    25 WIEPV------QRAEFDTDIAMVLKELDALRLDVKVDDTT----------LTLTRSEDGL----- 68

  Fly    70 TEQVAYGNSVQAFAQLCRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFN 134
                    .:|.|   |.:: |.|||                  |..|...|.|  |   .:|:|
  Fly    69 --------DMQRF---CEIL-STVGA------------------SAVIDLTYSH--W---EEGYN 98

  Fly   135 L-------HPSPEDIANALYDIVNQFEWSR------FIFCYESAEYLKILDHLMTRYGIKGPVIK 186
            |       :...|.|.....|:...|...:      .:| ..:.:.::.:..::..|..:..::.
  Fly    99 LVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVF-MNARDAVEAMQQMLVGYPFRTLIMD 162

  Fly   187 VMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNE-----------DYT 240
            ..:.|..     :..|.|||....       :.|.:|...|.|...||..:           ::.
  Fly   163 ASQTDPG-----QHFLERIRSLRP-------APTYIALFARAAAMNGIFEKVQKADLFQRPLEWH 215

  Fly   241 YIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEPVNS---GSTFITM 302
            ::.    |.|.| ..:||..            |.|:........:.:..|.|:..   ||.| ||
  Fly   216 FVF----LDTRD-RVFKYRR------------QAELCTRFTLNPRAICRSMPMPDLYCGSGF-TM 262

  Fly   303 EMALTYDAVRVIAETTKHLPYQPQML--NC------SERHDNVQPDG---------STFRNYMRS 350
            :.|:..:.:|.:....:..|..|..:  :|      ||..|.::.|.         |.|..|...
  Fly   263 QRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPP 327

  Fly   351 L-EIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVNFNDIDDGS 414
            | .|:::       |:..| .|.||.|       .:..|.:..    |.:.......::.:.:..
  Fly   328 LPHIQDQ-------FQSPV-PGLTFAV-------NISAGYYSS----EHEAKTDLAAWSSVGEMR 373

  Fly   415 LVNKT------FIVLISVATKPYASL--VESIDTLIGNNQ----FQGYGVDLIKELADKLGFNFT 467
            |:|:|      |..:.:..:.|::.|  .|....||.:..    ::||.:|.|..|:.||.|.|.
  Fly   374 LLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFE 438

  Fly   468 F--RDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFM-NLGIAILY 529
            .  .:.|: .|..|: .....|::.::|.|..|.||..|.:.|||||||||..|:. ..||:|..
  Fly   439 IVAPEVGH-MGELNE-LGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAI 501

  Fly   530 VKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDN-----PYPCIEEPEEL 589
            .||.:. .:||.||.....||||.:..|.:|.::..:.:.:.||....|     ||.|
  Fly   502 RKPVRR-TSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC------- 558

  Fly   590 ENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSP 654
             .:||:..|.||...:...||...||||:|.|.:.|.:|.|.::|::::|||||||||:|...:|
  Fly   559 -REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTP 622

  Fly   655 INSVKDLADNKDDVQYGAKRTGSTRNFF---STSEEPIYIKMNEY-LNAHPE------------- 702
            :.|::.|| .:..:.|...:...|..:|   ..:|:.:|....|. |||..:
  Fly   623 VQSLEQLA-RQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKE 686

  Fly   703 -----MLMENNQQGVDKVKSG---------TKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYG 753
                 :|..|:.|.|...|.|         ..|||:.:|..|::...|.||||:||:...|:.|.
  Fly   687 QYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYA 751

  Fly   754 IAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVV 818
            :|:.:.....|:.:.|:||||:......||.|:||:.....|....|.:|   :.:::|.|:::.
  Fly   752 VAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEG---ITLESLGGVFIA 813

  Fly   819 LVIGSIISII---ISILCWCYFVYKKAKN 844
            .:.|.:::::   :.:|     .|||.:|
  Fly   814 TLFGLVLAMMTLGMEVL-----YYKKKQN 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	74/406 (18%)
		ANF_receptor	46..380	CDD:279440	68/378 (18%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	128/421 (30%)
		Lig_chan	549..819	CDD:278489	89/305 (29%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	126/414 (30%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	89/309 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.910