DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Nmdar2

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster

Alignment Length:	999	Identity:	220/999 - (22%)
Similarity:	395/999 - (39%)	Gaps:	250/999 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISLIILSLSRVQA--QFYGGNAYE---ASSGQSIRLGLI---TDDATDRIRQTFEHAISVVNNEL 62
            ::|:||.....|.  ...||.:..   |::.:.:.:|||   |:.......::..:|::.:....
  Fly    68 LTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTR 132

  Fly    63 GVPLV------GETEQVAYG------NSVQAFAQLCR-LMQSGVGAV--------FGPAARHTAS 106
            |..|.      .|.:.:.:.      :.....:.||: .::..|.|:        ||.:.. :|.
  Fly   133 GAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTA-SAQ 196

  Fly   107 HLLNACDSKDIPFIYPHLSWGSNPDG-----------FNLHPSPEDIANALYDIVNQFEWSRFIF 160
            :.|.......||.|    ||.::..|           ..|.||.|..:.|:..|:.:::|.:|
  Fly   197 YFLQLAGYLGIPVI----SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQF-- 255

  Fly   161 CYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYK-SVLRRI---RKSE-------DSRIV 214
               |....:|..|......::..|.::..:       :| ::|..|   |.|:       ::|::
  Fly   256 ---SVVTSQIAGHDDFVQAVRERVAEMQEH-------FKFTILNSIVVTRTSDLMELVNSEARVM 310

  Fly   215 VVGST-TGVAELLRQAQQVGIMNEDYTYI----------------IGNLNLHTFDLEEYKYSEAN 262
            ::.:| |....:||.|:::.:..|:|.::                :|.|.:| ||..........
  Fly   311 LLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAHSQFPVGMLGVH-FDTSSAALMNEI 374

  Fly   263 ITGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQM 327
            ...|:::|                             ..:|..||..|.|....||       |.
  Fly   375 SNAIKIYS-----------------------------YGVEAYLTDPANRDRRLTT-------QS 403

  Fly   328 LNCSE----RHDNVQPDGSTFRNYMRSLEIKEKTITGRIYF--EGNVRKGFTFDVIELQTSGLVK 386
            |:|.:    |.||    |..|..|:|::.|:.......|.|  :|::|.. ...::.|:.|...|
  Fly   404 LSCEDEGRGRWDN----GEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSA-ELKIMNLRPSANNK 463

  Fly   387 VGTWEE---GKDFEFQR--------------PPQAV------NFNDIDDGSLVN---------KT 419
            ...|||   .|.:|.|:              |||.|      ....:::...:|         |.
  Fly   464 NLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKC 528

  Fly   420 FI---VLISVATKPYASLVESIDTLIG----NNQF----QGYGVDLIKELADKLGFNFTF---RD 470
            .:   ||..||..  ..:...||  :|    |..|    .|:.:||:::.|::|||.:..   .|
  Fly   529 LMDRGVLCRVAAD--HEMAADID--VGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVED 589

  Fly   471 GGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQK- 534
            |  .:|:..  ....:|::.::|..:.|:.:|.|.|.:|||.|:|||.|||..||||:..|...
  Fly   590 G--KWGTLE--NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGI 650

  Fly   535 -APPALFSFMDPFSSEVWLYLGI-AYLGVSLCFFIIGRLSPIEWD----------NPYPCIEEPE 587
             :|.|   |::||.:..|:.:|| |....:...|:...|||..:|          .||
  Fly   651 ISPTA---FLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPY------- 705

  Fly   588 ELENQFTINNSLWFTTGALLQQGSEI-APKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENP 651
                :|::..:.|.....|.|....: :|:..::|.::.:|..|.::.::.||||||||:.....
  Fly   706 ----RFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREE 766

  Fly   652 TSPINSVKDLA-----DNKDDVQYGA---KRTGSTRNFFSTSEEPIYIKMNEYLNAHPEMLMENN 708
            ....:.:.|..     .:|...::|.   ..|.||              :::|.|.....:.:.|
  Fly   767 FHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDST--------------IHKYFNVMHNYMRQYN 817

  Fly   709 Q----QGVDKVKSGTKYAFLMESTSIEFNTVR--ECNLTKVGDPLDEKGYGIAMVKNWPYRDKFN 767
            :    .||..|.:|...:|:.:.|.:::...:  :|.|..||......|||:|..:|..|...||
  Fly   818 KTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFN 882

  Fly   768 KALLELQEQGVLARLKNKWWNEVGAGVC-SAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISI 831
            |.|||.:..|.|.||:..|.    .|.| ..|.:......|.::.....:::|:.|.:::.::.:
  Fly   883 KRLLEFRANGDLERLRRYWM----TGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLL 943

  Fly   832 LCWCYFVY--KKAKNYEVPFCDAL 853
            |...||.|  |:....:...|.||
  Fly   944 LEHVYFKYIRKRLAKKDGGHCCAL 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	83/433 (19%)
		ANF_receptor	46..380	CDD:279440	72/399 (18%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	110/421 (26%)
		Lig_chan	549..819	CDD:278489	67/296 (23%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	85/449 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	112/445 (25%)
		Lig_chan	665..928	CDD:278489	67/291 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462856
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840