DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Gria4

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	878	Identity:	303/878 - (34%)
Similarity:	474/878 - (53%)	Gaps:	69/878 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SIRLGLITDDATDRIRQTFEHAISVVN-----NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSG 92
            |:::|.:....||:....|..||.:.|     :|....||...:.:...||.......|.....|
  Rat    26 SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRG 90

  Fly    93 VGAVFGPAARHTASHLLNACDSKDIPFIYPHL-SWGSNPDGFNLHPSPEDIANALYDIVNQFEWS 156
            |.|:||...:.:...|.:.|.:..|..|.|.. :.|.:.....|.||   :..||..:::.:||:
  Rat    91 VFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPS---LRGALLSLLDHYEWN 152

  Fly   157 RFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNG-NYKSVLRRIRKSEDSRIVVVGSTT 220
            .|:|.|::.....||..:|.:.|..|..:..:..: |.|. :|:.:|..:.:.::.:.|:.....
  Rat   153 CFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVE-NFNDVSYRQLLEELDRRQEKKFVIDCEIE 216

  Fly   221 GVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMF---SPDQEEVRDLMEK 282
            .:..:|.|...||...:.|.|||.||......||.:.:..||:||.::.   :|...::.|..:|
  Rat   217 RLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKK 281

  Fly   283 LHQE--LGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSER-------HDNVQ 338
            |.|.  .|...|....|       |||||.|.|:|||.:.|  :.|.::.|.|       .:...
  Rat   282 LDQREYPGSETPPKYTS-------ALTYDGVLVMAETFRSL--RRQKIDISRRGNAGDCLANPAA 337

  Fly   339 PDGSTFRNYMRSLEIKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEE-GKDFEFQRP 401
            |.|..........:::.:.:||.:.|:...|: .:|.||.||:::|..|||.|.: .|....|..
  Rat   338 PWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDM 402

  Fly   402 PQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNF 466
            |...|    |..::.|:| :|:.::...||....::.:...||::::||.|||..|:|..:|..:
  Rat   403 PTLGN----DTAAIENRT-VVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKY 462

  Fly   467 TFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAIL 528
            ...   ||  .||:.:..|...:||:.|:|.|:|::||..||||..||||||||.|||:|||:|:
  Rat   463 KIAIVPDG--KYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIM 525

  Fly   529 YVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELE--- 590
            ..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||..     ||||:.:
  Rat   526 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEPEDGKEGP 585

  Fly   591 -----NQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIEN 650
                 |:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||:|.
  Rat   586 SDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 650

  Fly   651 PTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVDK 714
            ..|||.|.:||| .:.::.||...:|||:.||..|:..:|.||..|: :|.|.:......:||.:
  Rat   651 MVSPIESAEDLA-KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVAR 714

  Fly   715 V-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQG 777
            | ||..|:|||:|||..|:...|: |:..|||..||.||||:|..|....|:..|.|:|:|.|||
  Rat   715 VRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRNAVNLAVLKLNEQG 779

  Fly   778 VLARLKNKWW---NEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVY 839
            :|.:||||||   .|.|:|...:|   |..|.|.:.|::|::.:||.|..::::::::.:||...
  Rat   780 LLDKLKNKWWYDKGECGSGGGDSK---DKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 841

  Fly   840 KKAKNYEVPFCDALAEEFRIVIRFS--ENERPL 870
            .:||..::.|.:|:..:.|:.|..|  ||.|.|
  Rat   842 AEAKRMKLTFSEAIRNKARLSITGSVGENGRVL 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	99/382 (26%)
		ANF_receptor	46..380	CDD:279440	89/353 (25%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	174/387 (45%)
		Lig_chan	549..819	CDD:278489	126/283 (45%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	99/382 (26%)
		ANF_receptor	39..380	CDD:279440	89/353 (25%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	174/389 (45%)
		Lig_chan	546..825	CDD:278489	128/287 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349877
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750