DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIID and Gria3

DIOPT Version :9

Sequence 1:NP_651982.1 Gene:GluRIID / 44483 FlyBaseID:FBgn0028422 Length:902 Species:Drosophila melanogaster
Sequence 2:NP_001106213.1 Gene:Gria3 / 29628 RGDID:70958 Length:888 Species:Rattus norvegicus


Alignment Length:844 Identity:284/844 - (33%)
Similarity:451/844 - (53%) Gaps:68/844 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 SIRLGLITDDATDRIRQTFEHAISVVN-----NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSG 92
            :|.:|.:....|.:....|..|:.:.|     .|....|....:.:...||.......|.....|
  Rat    27 TISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRG 91

  Fly    93 VGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPD-GFNLHPSPEDIANALYDIVNQFEWS 156
            |.|:||...:.:.:.|.:.|.:....|:.|  |:.::.| .|.:...|. :..|:..::..::|.
  Rat    92 VYAIFGFYDQMSMNTLTSFCGALHTSFVTP--SFPTDADVQFVIQMRPA-LKGAILSLLGYYKWE 153

  Fly   157 RFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSV--LRRI----RKSEDSRIVV 215
            :|::.|::.....:|..:|     :..|....:......||.|.|  .|||    .:.::.|.::
  Rat   154 KFVYLYDTERGFSVLQAIM-----EAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLI 213

  Fly   216 VGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLM 280
            ......:..:|.|...:|..:..|.|::.||......||...:..|||||.::.:.:...|:..:
  Rat   214 DCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFI 278

  Fly   281 EKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHD------NVQP 339
            :: ...|.|.|...:.:..:....|||:||:.||||..::|  :.|.::.|.|..      |...
  Rat   279 QR-WVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYL--RRQRVDVSRRGSAGDCLANPAV 340

  Fly   340 DGSTFRNYMRSLE-IKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEEGKDFEFQRPP 402
            ..|...:..|:|: ::.:.:||.|.|:...|: .:|.||.|::.||..|.|.|.|.:.|      
  Rat   341 PWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERF------ 399

  Fly   403 QAVNFND----IDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLG 463
              |.|:|    .|..|..|:| ||:.::...||....::.:.|.||.:::||.|||..|:|..:.
  Rat   400 --VPFSDQQISNDSSSSENRT-IVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVR 461

  Fly   464 FNFTFR-DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAI 527
            ..:... .|...||:.:..|...:||:.|:|.||||:|:..||||..||||||||.|||:|||:|
  Rat   462 IKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISI 526

  Fly   528 LYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEW---DNPYPCIEEPEEL 589
            :..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||   ||.    |||.:.
  Rat   527 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNN----EEPRDP 587

  Fly   590 E------NQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTI 648
            :      |:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||:
  Rat   588 QSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 652

  Fly   649 ENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGV 712
            |...|||.|.:||| .:.::.||...:|||:.||..|:..:|.||..|: :|.|.:..:....||
  Rat   653 ERMVSPIESAEDLA-KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV 716

  Fly   713 DKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQE 775
            .:| ||..|:|||:|||..|:...|: |:..|||..||.||||:|..|.....:..|.|:|:|.|
  Rat   717 ARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNE 781

  Fly   776 QGVLARLKNKWW---NEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCY 836
            ||:|.:||||||   .|.|:|...:|   |..|.|.:.|::|::.:||.|..::::::::.:||
  Rat   782 QGLLDKLKNKWWYDKGECGSGGGDSK---DKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 842

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIIDNP_651982.1 PBP1_iGluR_Kainate 35..397 CDD:107377 88/381 (23%)
ANF_receptor 46..380 CDD:279440 80/353 (23%)
PBP2_iGluR_Kainate 417..788 CDD:270432 175/386 (45%)
Lig_chan 549..819 CDD:278489 126/284 (44%)
Gria3NP_001106213.1 PBP1_iGluR_AMPA_GluR3 29..400 CDD:107382 89/389 (23%)
ANF_receptor 40..383 CDD:279440 80/353 (23%)
PBP2_iGluR_AMPA 416..799 CDD:270433 175/388 (45%)
Glutamate binding 502..504 0/1 (0%)
Lig_chan 548..829 CDD:278489 128/288 (44%)