Protein Alignment GluRIID and Gria2

DIOPT Version :10

• Sequence 1: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: NP_058957.1
• Gene: Gria2 / 29627
• RGDID: 61862
• Length: 883
• Species: Rattus norvegicus
• Alignment Length: 901
• Identity: 292/901 - (32%)
• Similarity: 473/901 - (52%)
• Gaps: 92/901 - (10%)

  Fly    30 SGQSIRLGLITDDATDRIRQTFEHAISVVN-NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSGV 93
            |..||::|.:.....|:....|.  :.:|. :.....|....:.:...||.......|.....||
  Rat    23 SSNSIQIGGLFPRGADQEYSAFR--VGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGV 85

  Fly    94 GAVFGPAARHTASHLLNACDSKDIPFIYPHL-SWGSNPDGFNLHPSPEDIANALYDIVNQFEWSR 157
            .|:||...:.:.:.:.:.|.:..:.||.|.. :.|::|....:.|   |:..||..::..::|.:
  Rat    86 YAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRP---DLKGALLSLIEYYQWDK 147

  Fly   158 FIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGN-----YKSVLRRIRKSEDSRIVVVG 217
            |.:.|:|...|..|..::.....|...:..:... |:|.:     |:|:.:.:...::.|:::..
  Rat   148 FAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVG-NINNDKKDETYRSLFQDLELKKERRVILDC 211

  Fly   218 STTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEK 282
            ....|.:::.|...:|...:.|.|||.||.....||.:.::..||::|.::...|...|...:|:
  Rat   212 ERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIER 276

  Fly   283 LHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRN- 346
             ...|.|.|...:.:..|....|||||||:|:.|..::|  :.|.:..|.|.:    .|....|
  Rat   277 -WSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNL--RKQRIEISRRGN----AGDCLANP 334

  Fly   347 ---------YMRSL-EIKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEEGKDFEFQR 400
                     ..|:| :::.:.::|.|.|:.|.:: .:|.:::||:|:|..|:|.|.|       .
  Rat   335 AVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSE-------V 392

  Fly   401 PPQAVNFNDIDDGS----LVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADK 461
            ....|...::..|:    |.||| :|:.::...||..:.::.:.|.||.:::||.|||..|:|..
  Rat   393 DKMVVTLTELPSGNDTSGLENKT-VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKH 456

  Fly   462 LGFNFTFR-DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGI 525
            .||.:... .|...||:.:..|...:||:.|:|.|:||:||..||||..||||||||.|||:|||
  Rat   457 CGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGI 521

  Fly   526 AILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPE--- 587
            :|:..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||..     ||.|
  Rat   522 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEFEDGR 581

  Fly   588 -----ELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLT 647
                 |..|:|.|.|||||:.||.::||.:|:|::||.|.:..:|||||||::||||||||||||
  Rat   582 ETQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 646

  Fly   648 IENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQG 711
            :|...|||.|.:||: .:.::.||...:|||:.||..|:..::.||..|: :|.|.:.:....:|
  Rat   647 VERMVSPIESAEDLS-KQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEG 710

  Fly   712 VDKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQ 774
            |.:| ||..|||:|:|||..|:...|: |:..|||..||.||||||..|........|.|:|:|.
  Rat   711 VARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLS 775

  Fly   775 EQGVLARLKNKWWNEVGAGVCSAKSDDDGPSE----LGVDNLSGIYVVLVIGSIISIIISILCWC 835
            |||||.:||||||.:  .|.|.||  |.|..|    |.:.|::|::.:||.|..::::::::.:|
  Rat   776 EQGVLDKLKNKWWYD--KGECGAK--DSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFC 836

  Fly   836 YFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSSQSIESLK 891
            |....:||..:|                      .|:.|:|...|..:||:..:.|
  Rat   837 YKSRAEAKRMKV----------------------AKNPQNINPSSSQNSQNFATYK 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..400	CDD:380605	86/383 (22%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	174/382 (46%)
		Lig_chan	547..819	CDD:459656	125/286 (44%)
Gria2	NP_058957.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	86/389 (22%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	176/389 (45%)
		Required for interaction with IQSEC1. /evidence=ECO:0000269|PubMed:20547133	867..877		1/4 (25%)