DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GRIK5

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	908	Identity:	301/908 - (33%)
Similarity:	478/908 - (52%)	Gaps:	90/908 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AYEASSGQ---SIRLGLITDDAT-----DRIRQTFEHAISVVNNELGVPLVGETE----QVAYGN 77
            |:.:.|.|   |:|:..|.||.|     :|:....  |...:|..:.||.....|    ::...:
Human    12 AFASPSCQVLSSLRMAAILDDQTVCGRGERLALAL--AREQINGIIEVPAKARVEVDIFELQRDS 74

  Fly    78 SVQAFAQLCRLMQSGVGAVFG----PAARHTASHLLNACDSKDIPFI---------YPHLSWGSN 129
            ..:....:|:::..||.:|.|    ||:..|.||:   |..|:||.|         ..:|.:.|
Human    75 QYETTDTMCQILPKGVVSVLGPSSSPASASTVSHI---CGEKEIPHIKVGPEETPRLQYLRFAS- 135

  Fly   130 PDGFNLHPSPEDIANALYDIVNQFEW-SRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLN 193
               .:|:||.||::.|:..|:..|.: |..:.| ..||.|..|:.|:..:.|....:.|...|.:
Human   136 ---VSLYPSNEDVSLAVSRILKSFNYPSASLIC-AKAECLLRLEELVRGFLISKETLSVRMLDDS 196

  Fly   194 LNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKY 258
            .:..  .:|:.||..:.|.|::..:.:....:||:|.::|:.:..|.||:..::.....|:....
Human   197 RDPT--PLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVE 259

  Fly   259 SEANITGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFI--TMEMALTYDAVRVIAETTKHL 321
            ..:||.|..||:.......:.:..|:....|:   ...||::  .:..||.:|||.|:....:.|
Human   260 DSSNILGFSMFNTSHPFYPEFVRSLNMSWREN---CEASTYLGPALSAALMFDAVHVVVSAVREL 321

  Fly   322 PYQPQM----LNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEG-NVRKGFTFDVIELQT 381
            ....::    |.|:..  |:.|.|::..||:|.:|.  ..:|||:.|.. ..|..:|..::|...
Human   322 NRSQEIGVKPLACTSA--NIWPHGTSLMNYLRMVEY--DGLTGRVEFNSKGQRTNYTLRILEKSR 382

  Fly   382 SGLVKVGTWEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQ 446
            .|..::|.|...:..........:|.:.    :|.||| :|:.::...||.....:...|.||.:
Human   383 QGHREIGVWYSNRTLAMNATTLDINLSQ----TLANKT-LVVTTILENPYVMRRPNFQALSGNER 442

  Fly   447 FQGYGVDLIKELADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIV-EGRADLAITDLTIT 507
            |:|:.||:::|||:.|.|.:..|   ||  .||: .:...|.:||:.|:: ..:||||:...|||
Human   443 FEGFCVDMLRELAELLRFRYRLRLVEDG--LYGA-PEPNGSWTGMVGELINRQKADLAVAAFTIT 504

  Fly   508 SEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLS 572
            :|||:|||||.|||.|||:|||.......|..|||:||||..|||::.:|||.||...|:..|||
Human   505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLS 569

  Fly   573 PIEWDNPYPCIE-EPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVS 636
            |.||.||:||:. .|..||||:|:.|||||..|..:||||||.|:|||||.:|.:||.||||::|
Human   570 PYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIIS 634

  Fly   637 SYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYLNA-H 700
            |||||||||||::....|:.|..|||| :.:::||....|||..||..|....|.:|..|:.: .
Human   635 SYTANLAAFLTVQRMEVPVESADDLAD-QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQ 698

  Fly   701 PEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDK 765
            |.:.:::.::|:.:|.: ::||||:|||..|::....||||::|..||.|||||.|....|:||:
Human   699 PSVFVKSTEEGIARVLN-SRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDE 762

  Fly   766 FNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIIS 830
            ...|:|:|||...|..||.|||.   .|.| .|.:|.....||::|:.||::||:.|.||::.::
Human   763 ITLAILQLQENNRLEILKRKWWE---GGRC-PKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVA 823

  Fly   831 ILCWCYFVYKKAKNYEVPF-------CDALA------EEFRIVIRFSENERPLKSAQSIYSRS 880
            ::.:.:...:.|::.|.|.       |.||.      |...::::.     |....|..:||:
Human   824 VMEFIWSTRRSAESEETPALHPAACQCSALGPRTPLKEPSMLLVKV-----PSTRVQVAFSRT 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	94/391 (24%)
		ANF_receptor	46..380	CDD:279440	86/358 (24%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	175/376 (47%)
		Lig_chan	549..819	CDD:278489	126/271 (46%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	94/392 (24%)
		ANF_receptor	42..379	CDD:279440	84/355 (24%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	175/376 (47%)
		Lig_chan	546..816	CDD:278489	128/275 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155978
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760