DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GRIK4

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	889	Identity:	292/889 - (32%)
Similarity:	469/889 - (52%)	Gaps:	72/889 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ASSGQSIRLGLITDDAT-----DRIRQTF-EHAISVVNNELGVPLVGETE--QVAYGNSVQAFAQ 84
            |.|..|:|:..|.||..     :|:..|. ::.|:.....||...| |.:  ::...:..:....
Human    19 ACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKV-EVDIFELLRDSEYETAET 82

  Fly    85 LCRLMQSGVGAVFGPAARHTASHLL-NACDSKDIPFIYPHLSWGSNPDGF-----------NLHP 137
            :|:::..||.||.||::...:|.:: |.|..|::    ||....  |:.|           ||||
Human    83 MCQILPKGVVAVLGPSSSPASSSIISNICGEKEV----PHFKVA--PEEFVKFQFQRFTTLNLHP 141

  Fly   138 SPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVL 202
            |..||:.|:..|:|.|..:........||.|..|:.|:.::.|....:.|...|...:..  .:|
Human   142 SNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPT--PLL 204

  Fly   203 RRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIR 267
            :.||..:.:.|::..:.:....:|.:|.::|:::..||||..||......::.......||.|..
Human   205 KEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFS 269

  Fly   268 MFSPDQEEVRDLMEKLHQELGES---EPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQM-- 327
            :|:......::..:.|:|...|:   .|.    |...:..||.:|||..:....:.|....::
Human   270 IFNQSHAFFQEFAQSLNQSWQENCDHVPF----TGPALSSALLFDAVYAVVTAVQELNRSQEIGV 330

  Fly   328 --LNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEG-NVRKGFTFDVIELQTSGLVKVGT 389
              |:|...  .:...|::..||:|.:|:  :.:||.|.|.. ..|..:...:::...:|..::|.
Human   331 KPLSCGSA--QIWQHGTSLMNYLRMVEL--EGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQ 391

  Fly   390 WEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDL 454
            |...:.........|.|.:|    :|.|.| :|:.::...||..|..:...:.||::::|:.||:
Human   392 WHVAEGLSMDSHLYASNISD----TLFNTT-LVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDM 451

  Fly   455 IKELADKLGFNFTFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIP 519
            :||||:.|.||:..|..|:......:...:.:||:.|::..:||||:..||||:|||:|||||.|
Human   452 LKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKP 516

  Fly   520 FMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIE 584
            ||.|||:|||.......|..|||:||||..|||::.:|||.||...|::.||:|.||.:|:||.:
Human   517 FMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQ 581

  Fly   585 -EPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTI 648
             ....|.||:::.|||||..|..:||||.|||:|||||.:|.:||.||||::||||||||||||:
Human   582 GRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTV 646

  Fly   649 ENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGV 712
            :....||.||.|||| :..::||....||:..||..|....|.:|..|: :..|.:.:::.::|:
Human   647 QRMDVPIESVDDLAD-QTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGI 710

  Fly   713 DKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQG 777
            .:|.: :.||||:|||..|:...|.||||::|..||.|||||.|.....:||:|:.|:|:|||..
Human   711 ARVLN-SNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENN 774

  Fly   778 VLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISIL--CWCYFVYK 840
            .|..||.|||.   .|.| .|.:|.....||::|:.||:|||:.|.|::|.:::|  .|   ..:
Human   775 RLEILKRKWWE---GGKC-PKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLW---TLR 832

  Fly   841 KAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSS 884
            .::..||..|..:..|.|.:|...:         ||:.|.|.::
Human   833 HSEATEVSVCQEMVTELRSIILCQD---------SIHPRRRRAA 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	88/389 (23%)
		ANF_receptor	46..380	CDD:279440	81/356 (23%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	169/372 (45%)
		Lig_chan	549..819	CDD:278489	124/271 (46%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	88/390 (23%)
		ANF_receptor	43..382	CDD:279440	80/355 (23%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	169/372 (45%)
		Lig_chan	547..816	CDD:278489	126/274 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155763
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760