back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GRIK2

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	891	Identity:	328/891 - (36%)
Similarity:	504/891 - (56%)	Gaps:	97/891 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 FEHAISVVN-NELGVP---LVGETEQVAYGNSVQAFAQLCRLMQSGVGAVFGPAARHTASHLLNA 111
            |..|::.:| |...:|   |..:|:::...:|.:|..:.|..:..||.|:|||:...:|:.:.:.
Human    57 FRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSI 121

  Fly   112 CDSKDIPFIYPHLSW----GSNPDGF--NLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKI 170
            |::..:|.|  ...|    ..|.|.|  :|:|....::.|:.|:|..|:|......|:.:..|..
Human   122 CNALGVPHI--QTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIR 184

  Fly   171 LDHLMTRYGIKGPVIKVMRYDLNL--------NGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLR 227
            |..|     ||.|    .||:|.|        ..:.|.:|:.:::.::..::...|....|.:|:
Human   185 LQEL-----IKAP----SRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK 240

  Fly   228 QAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEP 292
            ||..:|:|.|.|.||...|:|...|:|.|:||..|:||.|:.:.:..:|..::||...|..::.|
Human   241 QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPP 305

  Fly   293 -VNSG--STFITMEMALTYDAVRVIAETTKHLPYQPQM----LNCSERHDNVQP--DGSTFRNYM 348
             .:||  ..|:|.:.||.||||.|::...:..   |||    |.|: ||   :|  .|:.|.:.:
Human   306 KPDSGLLDGFMTTDAALMYDAVHVVSVAVQQF---PQMTVSSLQCN-RH---KPWRFGTRFMSLI 363

  Fly   349 RSLEIKEKTITGRIYFE--GNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVNFNDID 411
            :  |...:.:||||.|.  ..:|..|..|||.|:..||.|:|||:         |...:|..:..
Human   364 K--EAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWD---------PASGLNMTESQ 417

  Fly   412 DG-------SLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFR 469
            .|       ||.|::.|| .::..:||....:|...|.||::|:||.:||::||:..|||.:..|
Human   418 KGKPANITDSLSNRSLIV-TTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIR 481

  Fly   470 ---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVK 531
               ||  .||:.:......:||::|:::.:||||:..|.||..||:|||||.|||.|||:|||.|
Human   482 LVEDG--KYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRK 544

  Fly   532 PQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTIN 596
            |....|.:|||::|.|.::|:|:.:||||||...|:|.|.||.||.||:||..:.:.:||.||:.
Human   545 PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLL 609

  Fly   597 NSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDL 661
            ||.||..|||:|||||:.|||||||.:..||||||||::||||||||||||:|...|||:|..||
Human   610 NSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 674

  Fly   662 ADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYLNAHPE-MLMENNQQGVDKVKSGTKYAFLM 725
            | .:..::|||...|:|..||..|:...|.||..::::..: :|:::|::|:.:|.: :.|||||
Human   675 A-KQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLT-SDYAFLM 737

  Fly   726 ESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEV 790
            |||:|||.|.|.||||::|..:|.||||:......|||||...|:|:|||:|.|..:|.|||.
Human   738 ESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR-- 800

  Fly   791 GAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEV---PFCDA 852
            |.|....:|.:  .|.|||.|:.||::||..|.::|:.:::   ..|:||..||.::   .||.|
Human   801 GNGCPEEESKE--ASALGVQNIGGIFIVLAAGLVLSVFVAV---GEFLYKSKKNAQLEKRSFCSA 860

  Fly   853 LAEEFRIVIRFSENERPLKSAQSIYSRSRNSSQSIESLKTDSEENM 898
            :.||.|:.::...             |.::..|:...:||:...||
Human   861 MVEELRMSLKCQR-------------RLKHKPQAPVIVKTEEVINM 893

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.