Protein Alignment GluRIID and GRID2

DIOPT Version :9

• Sequence 1: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: XP_011530195.2
• Gene: GRID2 / 2895
• HGNCID: 4576
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 848
• Identity: 210/848 - (24%)
• Similarity: 384/848 - (45%)
• Gaps: 135/848 - (15%)

  Fly    86 CRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNP------------DGFNLHPS 138
            |.||..|:.|:.......:|..|.:..|:..||.::...|....|            |.:.|...
Human    95 CELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVR 159

  Fly   139 PE-DIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLN------- 195
            |. .:.:.:..:|.::.|.:||..|:|...::.:...:.:...:|..:.:.:.:.|:|
Human   160 PPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLF 224

  Fly   196 --------GNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFD 252
                    ..|:..|||       .|:|:...| ....:.:..:..::..|..:||.|..::..|
Human   225 DTMRIEELNRYRDTLRR-------AILVMNPAT-AKSFITEVVETNLVAFDCHWIIINEEINDVD 281

  Fly   253 LEE-YKYSEANITGIRMFSPDQEEVRDLMEKLHQELGES--EPVNSGSTFITMEMALTYDAVRVI 314
            ::| .:.|...:|.||...|..:.:.....:.:..:..:  :|.:..:..:.:.....||.|.::
Human   282 VQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLL 346

  Fly   315 AET-TKHLP----YQPQMLNCSERHDNVQPDGSTFRNYMR---------SLEIKEKTITGRIYFE 365
            |.. .|.|.    :....|:|..::......|.:....::         .||..|......::||
Human   347 ANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFE 411

  Fly   366 -----------GNVRKGFTFDVIELQ-TSGLV--KVGTWEEGKDFEFQRPPQAVNFNDIDDGSLV 416
                       ..|||.   :.|..| ::|.:  ::|.|         .|...:|      |||.
Human   412 ILGTNYGEELGRGVRKN---ERIRPQGSTGKIWPQLGCW---------NPVTGLN------GSLT 458

  Fly   417 NKTF------IVL--ISVATKPYASLVESIDTLIGN-NQFQGYGVDLIKELADKLGFNF-TFRDG 471
            :|..      :||  ::|..:|:..:.|::   :|. .::||:.:|::..|::.||||: .:...
Human   459 DKKLENNMRGVVLRVVTVLEEPFVMVSENV---LGKPKKYQGFSIDVLDALSNYLGFNYEIYVAP 520

  Fly   472 GNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAP 536
            .:.||| .:...:.:|::.|:|..|||:.|:.||||.:||.|:||:..:|:..:.:|..:.:|..
Human   521 DHKYGS-PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTV 584

  Fly   537 PALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWF 601
            . :|:.:.||...:|..:....|.|.|..::      :.|.|| |.::.......  |:.||:||
Human   585 D-MFACLAPFDLSLWACIAGTVLLVGLLVYL------LNWLNP-PRLQMGSMTST--TLYNSMWF 639

  Fly   602 TTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKD 666
            ..|:.:|||.|:....|:||.:...||.|.||::|||||||||||||....|.|.|::||: .:.
Human   640 VYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLS-KQT 703

  Fly   667 DVQYGAKRTGST------RNFFSTSEEPIYIKMNEYLNAHPEMLMENN----QQGVDKVKSGTKY 721
            ::.||.....:.      :.......:.:|.:|...:|....  .|||    |.|:.|||.| .|
Human   704 EIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNG--SENNVLESQAGIQKVKYG-NY 765

  Fly   722 AFLMESTSIEFNTVR--ECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKN 784
            ||:.::..:|:..:.  :|:...:|:.:.::|||||:....||||.|::.:||||:.|.:..||:
Human   766 AFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKH 830

  Fly   785 KWWNEVGAGVCSAKSDDDGPSE---LGVDNLSGIYVVLVIGSIISIIISIL-CWCYFVYKKAKNY 845
            |||.:  .|.|...|..|...:   |.:.:.:|::.:|..|.::|..|::| .|    :.|.|..
Human   831 KWWPK--NGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETW----WNKRKGS 889

  Fly   846 EVP 848
            .||
Human   890 RVP 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	65/369 (18%)
		ANF_receptor	46..380	CDD:279440	61/349 (17%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	123/392 (31%)
		Lig_chan	549..819	CDD:278489	90/284 (32%)
GRID2	XP_011530195.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740