DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GRID1

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	870	Identity:	214/870 - (24%)
Similarity:	411/870 - (47%)	Gaps:	113/870 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRLGLITDDATDRIRQTFEHAIS--VVNNELGVPLVGETEQVAY-------GNSVQAFAQLCRLM 89
            |.:|.|.::...:..:.|:.|:|  .:|::     :.::|::.|       .|..||..:.|.||
Human    24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDD-----ILQSEKITYSIKVIEANNPFQAVQEACDLM 83

  Fly    90 QSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNP-DGFNLHPSPEDIA---------- 143
            ..|:.|:.......:|:.|.:..|:..||.::...:.|.:| ...:|:|||:..|
Human    84 TQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVR 148

  Fly   144 --NALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIR 206
              :.:..:|.:..|.:|:..|:|...::.|...:.:....|..:.:.:.|.|::..:.|:...::
Human   149 LNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMK 213

  Fly   207 KSE-----DS--RIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSE-ANI 263
            ..|     |:  |.:::.|..|....:.:|.:..:.::|..::..|..:...::.:..:|. ..:
Human   214 TEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRM 278

  Fly   264 TGIRMFSPDQEEVRDLMEKLHQELG-ESEPVNSGSTFITMEMALTYDAVRVIA-------ETTKH 320
            |.:|...|..::.:......|:... ..:|.......:.:.....||:|.::|       |..|.
Human   279 TVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKW 343

  Fly   321 LPYQPQMLNCSERHDNVQPDGSTFRNYMRS---------LEIKEKTITGRIYFEGNVRKGFTFDV 376
              :....|||..:.......|.:..:.::.         :|.:|.:....:.||   ..|.|:.
Human   344 --HSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFE---ILGTTYS- 402

  Fly   377 IELQTSG--LVKVGTW--EEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVES 437
               :|.|  :.|:.||  |:|.:...|..|.         ||.:....:.:::|..:|:..:.|:
Human   403 ---ETFGKDMRKLATWDSEKGLNGSLQERPM---------GSRLQGLTLKVVTVLEEPFVMVAEN 455

  Fly   438 IDTLIGN-NQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNSTS--GMLKEIVEGRADL 499
            |   :|. .:::|:.:|::..||..|||.:......:  |.:....::||  ||:.|::..||||
Human   456 I---LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPD--GRYGHQLHNTSWNGMIGELISKRADL 515

  Fly   500 AITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLC 564
            ||:.:|||.|||.|:|||..:|:..:.||..||:: ..::||...||...||..:..|...|.:.
Human   516 AISAITITPERESVVDFSKRYMDYSVGILIKKPEE-KISIFSLFAPFDFAVWACIAAAIPVVGVL 579

  Fly   565 FFIIGRLSPIEWDN---PYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAI 626
            .|::.|:..:...:   |.|....        |:::::|...||.:|||.|.:..:::.|.:...
Human   580 IFVLNRIQAVRAQSAAQPRPSASA--------TLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGS 636

  Fly   627 WWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFST------S 685
            ||.||||:.||||||||||||:....:||.:.:||: .:.::.||..|..:...:|..      .
Human   637 WWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLS-KQVEMSYGTVRDSAVYEYFRAKGTNPLE 700

  Fly   686 EEPIYIKMNEYL--NAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFN--TVRECNLTKVGDP 746
            ::..:.::...:  |...:..:.:..:|:.|.|.| .||||.:...:|:.  |..:|::|.:|:.
Human   701 QDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKG-NYAFLWDVAVVEYAALTDDDCSVTVIGNS 764

  Fly   747 LDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCS----AKSDDDGPSEL 807
            :..||||||:....||||.|::.:||||:.|.|..||.|||..:|.  |.    |.:..||.| |
Human   765 ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGR--CDLTSHASAQADGKS-L 826

  Fly   808 GVDNLSGIYVVLVIGSIISIIISIL 832
            .:.:.:|::.:|.||.:::.:::.|
Human   827 KLHSFAGVFCILAIGLLLACLVAAL 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	75/412 (18%)
		ANF_receptor	46..380	CDD:279440	66/380 (17%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	121/386 (31%)
		Lig_chan	549..819	CDD:278489	87/286 (30%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		80/434 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	75/411 (18%)
		ANF_receptor	41..400	CDD:279440	65/368 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	121/385 (31%)
		Lig_chan	564..841	CDD:278489	88/289 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740