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Protein Alignment GluRIID and GRIA4

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	877	Identity:	302/877 - (34%)
Similarity:	470/877 - (53%)	Gaps:	67/877 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SIRLGLITDDATDRIRQTFEHAISVVN-----NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSG 92
            |:::|.:....||:....|..||.:.|     :|....||...:.:...||.......|.....|
Human    26 SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRG 90

  Fly    93 VGAVFGPAARHTASHLLNACDSKDIPFIYPHL-SWGSNPDGFNLHPSPEDIANALYDIVNQFEWS 156
            |.|:||...:.:...|.:.|.:..|..|.|.. :.|.:.....|.||   :..||..:::.:||:
Human    91 VFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPS---LRGALLSLLDHYEWN 152

  Fly   157 RFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNG-NYKSVLRRIRKSEDSRIVVVGSTT 220
            .|:|.|::.....||..:|.:.|..|..:..:..: |.|. :|:.:|..:.:.::.:.|:.....
Human   153 CFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVE-NFNDVSYRQLLEELDRRQEKKFVIDCEIE 216

  Fly   221 GVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMF---SPDQEEVRDLMEK 282
            .:..:|.|...||...:.|.|||.||......||.:.:..||:||.::.   :|...::.|..:|
Human   217 RLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKK 281

  Fly   283 LHQE--LGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSER-------HDNVQ 338
            |.|.  .|...|....|       |||||.|.|:|||.:.|  :.|.::.|.|       .:...
Human   282 LDQREYPGSETPPKYTS-------ALTYDGVLVMAETFRSL--RRQKIDISRRGNAGDCLANPAA 337

  Fly   339 PDGSTFRNYMRSLEIKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEE-GKDFEFQRP 401
            |.|..........:::.:.:||.:.|:...|: .:|.||.||:::|..|||.|.: .|....|..
Human   338 PWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDV 402

  Fly   402 PQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNF 466
            |...|    |..::.|:| :|:.::...||....::.:...||::::||.|||..|:|..:|..:
Human   403 PTLGN----DTAAIENRT-VVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKY 462

  Fly   467 TFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAIL 528
            ...   ||  .||:.:..|...:||:.|:|.|:|::||..||||..||||||||.|||:|||:|:
Human   463 KIAIVPDG--KYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIM 525

  Fly   529 YVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELE--- 590
            ..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||..     ||||:.:
Human   526 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEPEDGKEGP 585

  Fly   591 -----NQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIEN 650
                 |:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||:|.
Human   586 SDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 650

  Fly   651 PTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVDK 714
            ..|||.|.:||| .:.::.||...:|||:.||..|:..:|.||..|: :|.|.:......:||.:
Human   651 MVSPIESAEDLA-KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVAR 714

  Fly   715 V-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQG 777
            | ||..|:|||:|||..|:...|: |:..|||..||.||||:|..|....|...|.|:|:|.|.|
Human   715 VRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAG 779

  Fly   778 VLARLKNKWWNEVGAGVCSAK--SDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYK 840
            ||.:||||||.:  .|.|..|  ...|..|.|.:.|::|::.:||.|..::::::::.:||....
Human   780 VLDKLKNKWWYD--KGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRA 842

  Fly   841 KAKNYEVPFCDALAEEFRIVIRFS--ENERPL 870
            :||..::.|.:|:..:.|:.|..|  ||.|.|
Human   843 EAKRMKLTFSEAIRNKARLSITGSVGENGRVL 874

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.