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Protein Alignment GluRIID and GRIA2

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	901	Identity:	296/901 - (32%)
Similarity:	476/901 - (52%)	Gaps:	92/901 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SGQSIRLGLITDDATDRIRQTFEHAISVVN-NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSGV 93
            |..||::|.:.....|:....|.  :.:|. :.....|....:.:...||.......|.....||
Human    23 SSNSIQIGGLFPRGADQEYSAFR--VGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGV 85

  Fly    94 GAVFGPAARHTASHLLNACDSKDIPFIYPHL-SWGSNPDGFNLHPSPEDIANALYDIVNQFEWSR 157
            .|:||...:.:.:.:.:.|.:..:.||.|.. :.|::|....:.|   |:..||..::..::|.:
Human    86 YAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRP---DLKGALLSLIEYYQWDK 147

  Fly   158 FIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGN-----YKSVLRRIRKSEDSRIVVVG 217
            |.:.|:|...|..|..::.....|...:..:... |:|.:     |:|:.:.:...::.|:::..
Human   148 FAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVG-NINNDKKDEMYRSLFQDLELKKERRVILDC 211

  Fly   218 STTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEK 282
            ....|.:::.|...:|...:.|.|||.||.....||.:.::..||::|.::...|...|...:|:
Human   212 ERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIER 276

  Fly   283 LHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRN- 346
             ...|.|.|...:.:|.|....|||||||:|:.|..::|  :.|.:..|.|.:    .|....|
Human   277 -WSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNL--RKQRIEISRRGN----AGDCLANP 334

  Fly   347 ---------YMRSL-EIKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEEGKDFEFQR 400
                     ..|:| :::.:.::|.|.|:.|.:: .:|.:::||:|:|..|:|.|.|       .
Human   335 AVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSE-------V 392

  Fly   401 PPQAVNFNDIDDGS----LVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADK 461
            ....|...::..|:    |.||| :|:.::...||..:.::.:.|.||.:::||.|||..|:|..
Human   393 DKMVVTLTELPSGNDTSGLENKT-VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKH 456

  Fly   462 LGFNFTFR-DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGI 525
            .||.:... .|...||:.:..|...:||:.|:|.|:||:||..||||..||||||||.|||:|||
Human   457 CGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGI 521

  Fly   526 AILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPE--- 587
            :|:..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||..     ||.|
Human   522 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEFEDGR 581

  Fly   588 -----ELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLT 647
                 |..|:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||
Human   582 ETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 646

  Fly   648 IENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQG 711
            :|...|||.|.:||: .:.::.||...:|||:.||..|:..::.||..|: :|.|.:.:....:|
Human   647 VERMVSPIESAEDLS-KQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEG 710

  Fly   712 VDKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQ 774
            |.:| ||..|||:|:|||..|:...|: |:..|||..||.||||||..|....|...|.|:|:|.
Human   711 VARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLS 775

  Fly   775 EQGVLARLKNKWWNEVGAGVCSAKSDDDGPSE----LGVDNLSGIYVVLVIGSIISIIISILCWC 835
            |||||.:||||||.:  .|.|.||  |.|..|    |.:.|::|::.:||.|..::::::::.:|
Human   776 EQGVLDKLKNKWWYD--KGECGAK--DSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFC 836

  Fly   836 YFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSSQSIESLK 891
            |....:||..:|                      .|:||:|...|..:||:..:.|
Human   837 YKSRAEAKRMKV----------------------AKNAQNINPSSSQNSQNFATYK 870

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.