DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GRIA1

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001244950.1	Gene:	GRIA1 / 2890	HGNCID:	4571	Length:	916	Species:	Homo sapiens

Alignment Length:	900	Identity:	296/900 - (32%)
Similarity:	479/900 - (53%)	Gaps:	92/900 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RQTFEH-AISVVNNELGVP--LVGETEQVAYGNSVQAFAQLCRLMQSGVGAVFGPAARHTASHLL 109
            :|:.|| |.....::|..|  |:.:.:.|...:|.:...:.|.....||.|:||...|.|.:.|.
Human    44 QQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLT 108

  Fly   110 NACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHL 174
            :.|.:..:.||.|.....:: :.|.|...|| :.:||..|::.::|.:|::.|::...|.:|..:
Human   109 SFCGALHVCFITPSFPVDTS-NQFVLQLRPE-LQDALISIIDHYKWQKFVYIYDADRGLSVLQKV 171

  Fly   175 MTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDY 239
            :.....|...:..:.........|:.:.:.:.|.::..:||...:..:..:|.|..::......|
Human   172 LDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGY 236

  Fly   240 TYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKL-------HQELGESEPVNSGS 297
            .||:.||.....||.::|.|.||:||.::.:........:|::.       |..:....|..:.
Human   237 HYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTS- 300

  Fly   298 TFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRN----------YMRSL- 351
                   |||||.|:|:||..:.|  :.|.::.|.|.:    .|....|          ..|:|
Human   301 -------ALTYDGVKVMAEAFQSL--RRQRIDISRRGN----AGDCLANPAVPWGQGIDIQRALQ 352

  Fly   352 EIKEKTITGRIYF-EGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVNFN-DIDDGS 414
            :::.:.:||.:.| |...|..:|..|||::..|:.|:|.|.|...|    .|.|.:.. ..|:.|
Human   353 QVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKF----VPAATDAQAGGDNSS 413

  Fly   415 LVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFR---DGGNDYG 476
            :.|:|:|| .::...||..|.::.:...||::::||.|:|..|:|..:|:::...   ||  .||
Human   414 VQNRTYIV-TTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDG--KYG 475

  Fly   477 SFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFS 541
            :.:..|.:.:||:.|:|.||||:|:..||||..||||||||.|||:|||:|:..||||:.|.:||
Human   476 ARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS 540

  Fly   542 FMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEE--------LENQFTINNS 598
            |:||.:.|:|:.:..||:|||:..|::.|.||.||.:     ||.||        ..|:|.|.||
Human   541 FLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHS-----EEFEEGRDQTTSDQSNEFGIFNS 600

  Fly   599 LWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLAD 663
            |||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||:|...|||.|.:|||
Human   601 LWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA- 664

  Fly   664 NKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVDKV-KSGTKYAFLME 726
            .:.::.||....|||:.||..|:..::.||..|: :|.|.:.:...::|:.:| ||..|||:|:|
Human   665 KQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLE 729

  Fly   727 STSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEV 790
            ||..|:...|: |:..|||..||.||||||..|....|:..|.|:|:|.|||:|.:||||||.:
Human   730 STMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYD- 793

  Fly   791 GAGVCSAKSDD--DGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDAL 853
             .|.|.:...|  |..|.|.:.|::|::.:|:.|..::::::::.:||....::|..: .||...
Human   794 -KGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK-GFCLIP 856

  Fly   854 AEEFRIVIRFS----------------ENERPL-----KSAQSIYSRSRNSSQSI 887
            .:.....||.|                ||.|.:     ||.|||...|.:|...:
Human   857 QQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMPL 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	88/370 (24%)
		ANF_receptor	46..380	CDD:279440	83/353 (24%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	174/384 (45%)
		Lig_chan	549..819	CDD:278489	124/282 (44%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385	89/374 (24%)
		ANF_receptor	47..382	CDD:279440	82/350 (23%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	176/391 (45%)
		Lig_chan	548..827	CDD:278489	125/286 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155945
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750