DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Grin2d

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	200/993 - (20%)
Similarity:	382/993 - (38%)	Gaps:	269/993 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AQFYGGNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGVPLVGETEQVAYGNSVQAF 82
            |..:.|.||.|   ::.|||               .|::......|:. |.....|..|:..::.
  Rat    51 ALVFSGPAYAA---EAARLG---------------PAVAAAVRSPGLD-VRPVALVLNGSDPRSL 96

  Fly    83 A-QLCRLMQSGV---GAVFGPAARHTA-SHLLNACDSK-DIPFIYPH----------------LS 125
            . |||.|: ||:   |.||...:|..| :.:|:...:: .:|.:..|                |.
  Rat    97 VLQLCDLL-SGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQ 160

  Fly   126 WGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESA-------EYLKIL-DHLMTRYGIKG 182
            .||         |.|.....:::::.:::|:.|:.....|       .|:::| |..:..:..:|
  Rat   161 LGS---------STEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRG 216

  Fly   183 PVIKVMRYDLNLN-GNYKSVLRRIRKSEDSRIVVVGSTTGVAE-LLRQAQQVGIMNEDYTYIIGN 245
            .        |.|: |..::||....:|..::|.::......|| :.|.|::.|:....|.:.:..
  Rat   217 A--------LTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVG 273

  Fly   246 LNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDA 310
            ..|       .....:.:.|..:..|.                 ..|:.:| .|.........|.
  Rat   274 PQL-------AGGGGSGVPGEPLLLPG-----------------GSPLPAG-LFAVRSAGWRDDL 313

  Fly   311 VR-------VIAETTKHL----PYQPQM-LNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIY 363
            .|       |:|...:.|    .:.|:: .:|  |..|....|.:...|..::
  Rat   314 ARRVAAGVAVVARGAQALLRDYGFLPELGHDC--RTQNRTHRGESLHRYFMNI------------ 364

  Fly   364 FEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVL----- 423
                                     || :.:|:.|.           :||.|||.:.:|:
  Rat   365 -------------------------TW-DNRDYSFN-----------EDGFLVNPSLVVISLTRD 392

  Fly   424 ------------------------------------ISVAT---KPYASLVESIDTLIG------ 443
                                                ::|||   :|:. :||..|.:.|
  Rat   393 RTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFV-IVEPADPISGTCIRDS 456

  Fly   444 ---NNQF------------------QGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNST-S 486
               .:|.                  :|:.:|::|.||..:||::......|  |...|..:.. :
  Rat   457 VPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTN--GKHGKKIDGVWN 519

  Fly   487 GMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQ--KAPPALFSFM------ 543
            ||:.|:...|||:||..|||..||.|::|||:||:..||:::..:..  .:|.|..:|.
  Rat   520 GMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLTPPM 584

  Fly   544 --DPFSSEVWLYLGIAYLG-VSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGA 605
              :|:|..||:.:.:..|. |::..||...|||:.::......:.|.  .:.|||..|:|.....
  Rat   585 SPEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPG--GSTFTIGKSIWLLWAL 647

  Fly   606 LLQQGSEIA-PKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQ 669
            :......:. |:..:::.:..:|.||.:|.::|||||||||:..|.....::.:.|....:...|
  Rat   648 VFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQ 712

  Fly   670 YGAKRTGSTRNFFSTSEEPIYIKMNEYLNAHPEMLMENN---QQGVDKVKSGTKYAFLMESTSIE 731
            |...:.|:..|  .::|:.|   .:.|.:.|..|:..|.   ::.:.::|:|...||:.::..:.
  Rat   713 YPPLKFGTVPN--GSTEKNI---RSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLN 772

  Fly   732 FNTVRE--CNLTKVGD--PLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGA 792
            :...::  |.|..:|.  .....|||||:.|...::...:.|||:......:..|:..|.    :
  Rat   773 YMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL----S 833

  Fly   793 GVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEF 857
            |:|.....:...|:|.:||::|::.:|::...:|::  :..|.:.||.:.::     |.......
  Rat   834 GICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLL--VFAWEHLVYWRLRH-----CLGPTHRM 891

  Fly   858 RIVIRFSENERPLKSAQS 875
            ..::.||.......||::
  Rat   892 DFLLAFSRGMYSCCSAEA 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	67/405 (17%)
		ANF_receptor	46..380	CDD:279440	61/377 (16%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	106/461 (23%)
		Lig_chan	549..819	CDD:278489	66/278 (24%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601	79/471 (17%)
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	106/424 (25%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740