DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Grin2c

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	1004	Identity:	226/1004 - (22%)
Similarity:	406/1004 - (40%)	Gaps:	235/1004 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SLIILSLSRVQAQFYGGNAYEASS-----GQSIRLGLITDDATDRIRQTFEHAISVVNNELGVPL 66
            :|::.||....|:...|...:|.:     |.|   |.:...|..|:..         .|.|.:||
  Rat    21 ALLLTSLLGAWARLGAGQGEQAVTVAVVFGSS---GPLQTQARTRLTS---------QNFLDLPL 73

  Fly    67 VGETEQVAYG----NSVQAFAQLCRLMQSGVGAVFG-----PAARHTASHLLNACDSK-DIPFIY 121
              |.:.:..|    |......|:|.|:  |...|.|     .......:.||:...|: .:|.:
  Rat    74 --EIQPLTVGVNNTNPSSILTQICGLL--GAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPIL- 133

  Fly   122 PHLSWGS-------NPDG--FNLHPSPEDIANALYDIVNQFEWSRF----------------IFC 161
             .:|.||       .|..  ..|..|.|.....|:.::.:::||.|                :..
  Rat   134 -SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRA 197

  Fly   162 YESAEYL--KILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAE 224
            ...|.||  ::||.|....|..||..:..|           :||::    |:.::|...:...||
  Rat   198 VADASYLSWRLLDVLTLELGPGGPRARTQR-----------LLRQV----DAPVLVAYCSREEAE 247

  Fly   225 LL-RQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVR-DLMEKLHQEL 287
            :| .:|.|.|::...:.:::.||.|.:.|.....:.      :.:.|...|..| .|.:|:.
  Rat   248 VLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFP------VGLISVVTESWRLSLRQKVR--- 303

  Fly   288 GESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQML-----NCSERHDNVQPDGSTFRNY 347
                                 |.|.::|........|...|     :|......|.|....|..:
  Rat   304 ---------------------DGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRH 347

  Fly   348 MRSLEIKEKTITGRIYFEGNVRKGFTFD-----------VIELQTSGLVK-VGTWEEGKDFEFQR 400
            :.:           :.:||   :.|:|.           ||.|....|.: ||.|:.|  ..:.:
  Rat   348 LLN-----------VTWEG---RDFSFSPGGYLVRPTMVVIALNRHRLWEMVGRWDHG--VLYMK 396

  Fly   401 PPQAVNFNDIDDGSL---VNKTFIVLISVATKPYASLVESIDTLIG-------------NNQF-- 447
            .|....::.    ||   |:...:.:.::..:|:. :|||.|...|             |:.|
  Rat   397 YPVWPRYST----SLQPVVDSRHLTVATLEERPFV-IVESPDPGTGGCVPNTVPCRRQSNHTFSS 456

  Fly   448 -----------QGYGVDLIKELADKLGFNFTF------RDGGNDYGSFNKTTNSTSGMLKEIVEG 495
                       :|:.:|::|:||..:.|::..      :.|....|.:|       ||:.|:...
  Rat   457 GDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWN-------GMIGEVYYK 514

  Fly   496 RADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLG 560
            |||:||..|||..||.|:||||:||:..||::: |.......:..:|::|:|..||:.:.:..|.
  Rat   515 RADMAIGSLTINEERSEIIDFSVPFVETGISVM-VSRSNGTVSPSAFLEPYSPAVWVMMFVMCLT 578

  Fly   561 -VSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIA-PKALSTRTI 623
             |::..|:....||:.::......::|.  ...|||..|:|.....:......|. |:..:::.:
  Rat   579 VVAITVFMFEYFSPVSYNQNLTKGKKPG--GPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIM 641

  Fly   624 SAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEP 688
            ..:|.||.:|.::|||||||||:..|.....::.:.|....:...||...|.|:..|  .::|..
  Rat   642 VLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPN--GSTERN 704

  Fly   689 IYIKMNEYLNAHPEMLMENNQQGVD----KVKSGTKYAFLMESTSIEFNTVRE--CNLTKVGD-- 745
            |   .:.|.:.|..| ::.||:.|:    .:|.|...||:.::..:.:...::  |.|..:|.
  Rat   705 I---RSNYRDMHTHM-VKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGK 765

  Fly   746 PLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVD 810
            .....||||||.|:..::...:.|||:|...|...:|:..|.    :|:|..:.::...|:|.:|
  Rat   766 VFATTGYGIAMQKDSHWKRAIDLALLQLLGDGETQKLETVWL----SGICQNEKNEVMSSKLDID 826

  Fly   811 NLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQS 875
            |::|::.:|::.  :.:.:.:..|.:.||.|.: :.||    .:.:...::.||         :.
  Rat   827 NMAGVFYMLLVA--MGLALLVFAWEHLVYWKLR-HSVP----NSSQLDFLLAFS---------RG 875

  Fly   876 IYSRSRNSSQSIES--------LKTDSEE 896
            ||| ..|..||:.|        |..||.:
  Rat   876 IYS-CFNGVQSLPSPARPPSPDLTADSAQ 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	81/417 (19%)
		ANF_receptor	46..380	CDD:279440	73/388 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	107/412 (26%)
		Lig_chan	549..819	CDD:278489	71/279 (25%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	84/434 (19%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	109/420 (26%)
		NMDAR2_C	850..>925	CDD:402274	17/69 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740