Protein Alignment GluRIID and Grik5

DIOPT Version :10

• Sequence 1: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: XP_006228444.1
• Gene: Grik5 / 24407
• RGDID: 2735
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 903
• Identity: 302/903 - (33%)
• Similarity: 477/903 - (52%)
• Gaps: 82/903 - (9%)

  Fly    33 SIRLGLITDDAT-----DRIRQTFEHAISVVNNELGVPLVGETE----QVAYGNSVQAFAQLCRL 88
            |:|:..|.||.|     :|:....  |...:|..:.||.....|    ::...:..:....:|::
  Rat    23 SLRMAAILDDQTVCGRGERLALAL--AREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQI 85

  Fly    89 MQSGVGAVFG----PAARHTASHLLNACDSKDIPFI---------YPHLSWGSNPDGFNLHPSPE 140
            :..||.:|.|    ||:..|.||:   |..|:||.|         ..:|.:.|    .:|:||.|
  Rat    86 LPKGVVSVLGPSSSPASASTVSHI---CGEKEIPHIKVGPEETPRLQYLRFAS----VSLYPSNE 143

  Fly   141 DIANALYDIVNQFEW-SRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRR 204
            |::.|:..|:..|.: |..:.| ..||.|..|:.|:..:.|....:.|...|.:.:..  .:|:.
  Rat   144 DVSLAVSRILKSFNYPSASLIC-AKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT--PLLKE 205

  Fly   205 IRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMF 269
            ||..:.|.|::..:.:....:||:|.::|:.:..|.||:..::.....|:......:||.|..||
  Rat   206 IRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMF 270

  Fly   270 SPDQEEVRDLMEKLHQELGESEPVNSGSTF--ITMEMALTYDAVRVIAETTKHLPYQPQM----L 328
            :.......:.:..|:....|:   ...||:  ..:..||.:|||.|:....:.|....::    |
  Rat   271 NTSHPFYPEFVRSLNMSWREN---CEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPL 332

  Fly   329 NCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEG-NVRKGFTFDVIELQTSGLVKVGTWEE 392
            .|:..  |:.|.|::..||:|.:|.  ..:|||:.|.. ..|..:|..::|....|..::|.|..
  Rat   333 ACTSA--NIWPHGTSLMNYLRMVEY--DGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYS 393

  Fly   393 GKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKE 457
            .:..........:|.:.    :|.||| :|:.::...||.....:...|.||.:|:|:.||:::|
  Rat   394 NRTLAMNATTLDINLSQ----TLANKT-LVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRE 453

  Fly   458 LADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIV-EGRADLAITDLTITSEREEVIDFSI 518
            ||:.|.|.:..|   ||  .||: .:...|.:||:.|:: ..:||||:...|||:|||:|||||.
  Rat   454 LAELLRFRYRLRLVEDG--LYGA-PEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSK 515

  Fly   519 PFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCI 583
            |||.|||:|||.......|..|||:||||..|||::.:|||.||...|:..||||.||.||:||:
  Rat   516 PFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCL 580

  Fly   584 E-EPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLT 647
            . .|..||||:|:.|||||..|..:||||||.|:|||||.:|.:||.||||::||||||||||||
  Rat   581 RARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLT 645

  Fly   648 IENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYLNA-HPEMLMENNQQG 711
            ::....|:.|..|||| :.:::||....|||..||..|....|.:|..|:.: .|.:.:::.::|
  Rat   646 VQRMEVPVESADDLAD-QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEG 709

  Fly   712 VDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQ 776
            :.:|.: ::||||:|||..|::....||||::|..||.|||||.|....|:||:...|:|:|||.
  Rat   710 IARVLN-SRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQEN 773

  Fly   777 GVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKK 841
            ..|..||.|||.   .|.| .|.:|.....||::|:.||:|||:.|.||::.::::.:.:...:.
  Rat   774 NRLEILKRKWWE---GGRC-PKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRS 834

  Fly   842 AKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSR----NSSQSIESLKTDSE 895
            |::.||..|..:.:|.|..:...:..|         ||.|    ..|:::.||:...|
  Rat   835 AESEEVSVCQEMLQELRHAVSCRKTSR---------SRRRRRPGGPSRALLSLRAVRE 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..400	CDD:380605	94/394 (24%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	175/376 (47%)
		Lig_chan	547..819	CDD:459656	128/273 (47%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	95/396 (24%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	175/376 (47%)