DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Grik5

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	903	Identity:	302/903 - (33%)
Similarity:	477/903 - (52%)	Gaps:	82/903 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SIRLGLITDDAT-----DRIRQTFEHAISVVNNELGVPLVGETE----QVAYGNSVQAFAQLCRL 88
            |:|:..|.||.|     :|:....  |...:|..:.||.....|    ::...:..:....:|::
  Rat    23 SLRMAAILDDQTVCGRGERLALAL--AREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQI 85

  Fly    89 MQSGVGAVFG----PAARHTASHLLNACDSKDIPFI---------YPHLSWGSNPDGFNLHPSPE 140
            :..||.:|.|    ||:..|.||:   |..|:||.|         ..:|.:.|    .:|:||.|
  Rat    86 LPKGVVSVLGPSSSPASASTVSHI---CGEKEIPHIKVGPEETPRLQYLRFAS----VSLYPSNE 143

  Fly   141 DIANALYDIVNQFEW-SRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRR 204
            |::.|:..|:..|.: |..:.| ..||.|..|:.|:..:.|....:.|...|.:.:..  .:|:.
  Rat   144 DVSLAVSRILKSFNYPSASLIC-AKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT--PLLKE 205

  Fly   205 IRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMF 269
            ||..:.|.|::..:.:....:||:|.::|:.:..|.||:..::.....|:......:||.|..||
  Rat   206 IRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMF 270

  Fly   270 SPDQEEVRDLMEKLHQELGESEPVNSGSTF--ITMEMALTYDAVRVIAETTKHLPYQPQM----L 328
            :.......:.:..|:....|:   ...||:  ..:..||.:|||.|:....:.|....::    |
  Rat   271 NTSHPFYPEFVRSLNMSWREN---CEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPL 332

  Fly   329 NCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEG-NVRKGFTFDVIELQTSGLVKVGTWEE 392
            .|:..  |:.|.|::..||:|.:|.  ..:|||:.|.. ..|..:|..::|....|..::|.|..
  Rat   333 ACTSA--NIWPHGTSLMNYLRMVEY--DGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYS 393

  Fly   393 GKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKE 457
            .:..........:|.:.    :|.||| :|:.::...||.....:...|.||.:|:|:.||:::|
  Rat   394 NRTLAMNATTLDINLSQ----TLANKT-LVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRE 453

  Fly   458 LADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIV-EGRADLAITDLTITSEREEVIDFSI 518
            ||:.|.|.:..|   ||  .||: .:...|.:||:.|:: ..:||||:...|||:|||:|||||.
  Rat   454 LAELLRFRYRLRLVEDG--LYGA-PEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSK 515

  Fly   519 PFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCI 583
            |||.|||:|||.......|..|||:||||..|||::.:|||.||...|:..||||.||.||:||:
  Rat   516 PFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCL 580

  Fly   584 E-EPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLT 647
            . .|..||||:|:.|||||..|..:||||||.|:|||||.:|.:||.||||::||||||||||||
  Rat   581 RARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLT 645

  Fly   648 IENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYLNA-HPEMLMENNQQG 711
            ::....|:.|..|||| :.:::||....|||..||..|....|.:|..|:.: .|.:.:::.::|
  Rat   646 VQRMEVPVESADDLAD-QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEG 709

  Fly   712 VDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQ 776
            :.:|.: ::||||:|||..|::....||||::|..||.|||||.|....|:||:...|:|:|||.
  Rat   710 IARVLN-SRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQEN 773

  Fly   777 GVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKK 841
            ..|..||.|||.   .|.| .|.:|.....||::|:.||:|||:.|.||::.::::.:.:...:.
  Rat   774 NRLEILKRKWWE---GGRC-PKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRS 834

  Fly   842 AKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSR----NSSQSIESLKTDSE 895
            |::.||..|..:.:|.|..:...:..|         ||.|    ..|:::.||:...|
  Rat   835 AESEEVSVCQEMLQELRHAVSCRKTSR---------SRRRRRPGGPSRALLSLRAVRE 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	94/391 (24%)
		ANF_receptor	46..380	CDD:279440	86/358 (24%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	175/376 (47%)
		Lig_chan	549..819	CDD:278489	127/271 (47%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	95/396 (24%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	175/376 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.660