DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Grik4

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus

Alignment Length:	874	Identity:	291/874 - (33%)
Similarity:	464/874 - (53%)	Gaps:	63/874 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ASSGQSIRLGLITDDAT-----DRIRQTF-EHAISVVNNELGVPLVGETE--QVAYGNSVQAFAQ 84
            |.|..|:|:..|.||..     :|:..|. ::.|:.....||...| |.:  ::...:..:....
  Rat    19 ACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKV-EVDIFELLRDSEYETAET 82

  Fly    85 LCRLMQSGVGAVFGPAARHTASHLL-NACDSKDIPFIYPHLSWGSNPDGF-----------NLHP 137
            :|:::..||.||.||::...:|.:: |.|..|::    ||....  |:.|           ||||
  Rat    83 MCQILPKGVVAVLGPSSSPASSSIISNICGEKEV----PHFKVA--PEEFVRFQLQRFTTLNLHP 141

  Fly   138 SPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVL 202
            |..||:.|:..|:|.|..:........||.|..|:.|:.::.|....:.|...|...:..  .:|
  Rat   142 SNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPT--PLL 204

  Fly   203 RRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIR 267
            :.||..:.:.|::..:.:....:|.:|.::|:::..||||..||......::.......||.|..
  Rat   205 KEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFS 269

  Fly   268 MFSPDQEEVRDLMEKLHQELGES---EPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQM-- 327
            :|:......::..:.|:|...|:   .|.    |...:..||.:|||..:....:.|....::
  Rat   270 IFNQSHAFFQEFSQSLNQSWQENCDHVPF----TGPALSSALLFDAVYAVVTAVQELNRSQEIGV 330

  Fly   328 --LNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEG-NVRKGFTFDVIELQTSGLVKVGT 389
              |:|...  .:...|::..||:|.:|:  :.:||.|.|.. ..|..:...:::...:|..::|.
  Rat   331 KPLSCGSA--QIWQHGTSLMNYLRMVEL--EGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQ 391

  Fly   390 WEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDL 454
            |...:.........|.|.:|    ||.|.| :|:.::...||..|..:...:.||::::|:.||:
  Rat   392 WHVAEGLSMDSRLYASNISD----SLFNTT-LVVTTILENPYLMLKGNHQDMEGNDRYEGFCVDM 451

  Fly   455 IKELADKLGFNFTFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIP 519
            :||||:.|.||:..|..|:......:...:.:||:.|::..:||||:..||||:|||:|||||.|
  Rat   452 LKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKP 516

  Fly   520 FMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIE 584
            ||.|||:|||.......|..|||:||||..|||::.:|||.||...|::.||:|.||.:|:||.:
  Rat   517 FMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQ 581

  Fly   585 -EPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTI 648
             ....|.||:::.|||||..|..:||||.|||:|||||.:|.:||.||||::||||||||||||:
  Rat   582 GRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTV 646

  Fly   649 ENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGV 712
            :....||.||.|||| :..::||....||:..||..|....|.:|..|: :..|.:.:::.::|:
  Rat   647 QRMEVPIESVDDLAD-QTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGI 710

  Fly   713 DKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQG 777
            .:|.: :.||||:|||..|:...|.||||::|..||.|||||.|.....:||:|:.|:|:|||..
  Rat   711 ARVLN-SNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENN 774

  Fly   778 VLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISIL--CWCYFVYK 840
            .|..||.|||.   .|.| .|.:|.....||::|:.||:|||:.|.|::|.:::|  .|   ..:
  Rat   775 RLEILKRKWWE---GGKC-PKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLW---TLR 832

  Fly   841 KAKNYEVPFCDALAEEFRIVIRFSENERP 869
            .::..||..|..:..|.|.:|...:|..|
  Rat   833 HSEASEVSVCQEMMTELRSIILCQDNIHP 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	88/389 (23%)
		ANF_receptor	46..380	CDD:279440	81/356 (23%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	169/372 (45%)
		Lig_chan	549..819	CDD:278489	124/271 (46%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	89/394 (23%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	169/372 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760