DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Grin3a

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	917	Identity:	201/917 - (21%)
Similarity:	372/917 - (40%)	Gaps:	201/917 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 IPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIK 181
            :||..|...|.|:|..|        :.:..:.:|.|...:...|.....|.:: ||.:.:...|
Mouse   164 MPFSSPSSPWSSDPFSF--------LQSVCHTVVVQGVSALLAFPQSQGEMME-LDLVSSVLHI- 218

  Fly   182 GPVIKVMRYD--------LNLNGNYKSVLRRIRKSEDSRIVV----VGSTTGVAELLRQAQQVGI 234
             ||:.::|::        |:|..:.::.|     |.|:.:.|    :.:....:.||.|
Mouse   219 -PVLSIVRHEFPRESQNPLHLQLSLENSL-----SSDADVTVSILTMNNWYNFSLLLCQ------ 271

  Fly   235 MNEDYT---YIIGNLNLHTFDLEEYKYSEANITGIR---------------------MFSPDQEE 275
              ||:.   :::...|...|.||......||::..:                     ||..|...
Mouse   272 --EDWNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGS 334

  Fly   276 VRDLME----------KLHQELGESEPVNS-------------GST-------FITMEMALTYDA 310
            :|.:.|          .||..||:|:.|..             |.|       ::...|.|...|
Mouse   335 IRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARA 399

  Fly   311 VRVIAETTKHLPYQPQMLNCSERHDNVQPDG---------STFRNYMRSLEIKEKTITGRIYFEG 366
            |.........|...|..:||.:........|         :|||....|:::|..||   :..|.
Mouse   400 VATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTI---VSSEN 461

  Fly   367 NVRKGFTFDVIELQTSGL-----VKVGTWEEGK---------------DFEFQRPPQA------- 404
            |      |.:..||...:     .::|:|:.|:               ...|..|.:.
Mouse   462 N------FFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTL 520

  Fly   405 -----VNFNDIDDGSLVNKTFIVL------ISVATKPYASLVESIDTLIGNNQFQ----GYGVDL 454
                 |...::||..|.....:.|      .|:....::||..|.||:  ..:|:    ||.:||
Mouse   521 IEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTV--PIKFKKCCYGYCIDL 583

  Fly   455 IKELADKLGFNF-TFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSI 518
            :::||:.:.|:| .:..|...||::.  ....:|::.:::.|.|::|:|..:|.:.|.:||||:.
Mouse   584 LEQLAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTS 646

  Fly   519 PFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCI 583
            ||.:..:.|| |:.:.....:.:||.|....:||.:.:| |.::..|     |:..||.:|:...
Mouse   647 PFFSTSLGIL-VRTRDTAAPIGAFMWPLHWTMWLGIFVA-LHITAIF-----LTLYEWKSPFGMT 704

  Fly   584 EEPEELENQFTINNSLWFTTGALLQQGSEI-APKALSTRTISAIWWFFTLIMVSSYTANLAAFLT 647
            .:.......|:.:::|......|..:.:.| .||..:.|.:..:|..|.:..:|:|||||||.:.
Mouse   705 PKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMV 769

  Fly   648 IENPTSPINSVKD--LADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYLN-----AHPE--M 703
            .|.....::.:.|  |.......::|..|..|..::...|    :.:|:||:.     |.|:  .
Mouse   770 GEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS----FPEMHEYMRRYNVPATPDGVQ 830

  Fly   704 LMENNQQGVDKVKSGTKYAFLMESTSIEFNTV--RECNLTKVGDPLDEKGYGIAMVKNWPYRDKF 766
            .::|:.:.:|        ||:|:...:::...  .:|.|..||.|...:||||.:..|.|.....
Mouse   831 YLKNDPEKLD--------AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNI 887

  Fly   767 NKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISI 831
            ::.:.:.:..|.:..|.:||:..|..|..|....:  ..::|:.:.||::|:|.||..:||:.:|
Mouse   888 SELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTE--TLQMGIKHFSGLFVLLCIGFGLSILTTI 950

  Fly   832 LCWCYFVYK----KAKN-YEVPFCDALAEEFRIVIR--FSENERPLKSAQSI-YSRSRNSSQSIE 888
              ..:.||:    :.|| .::.:....::.|...:.  |.|.::|....:.: .||.|..:...|
Mouse   951 --GEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKSRWRRWTCKTE 1013

  Fly   889 SLKTDSE 895
            .   |||
Mouse  1014 G---DSE 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	71/374 (19%)
		ANF_receptor	46..380	CDD:279440	66/337 (20%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	96/393 (24%)
		Lig_chan	549..819	CDD:278489	65/281 (23%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	71/365 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	99/418 (24%)
		Lig_chan	676..942	CDD:278489	67/285 (24%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		5/35 (14%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846384
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740