DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIID and W02A2.5

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_502564.2	Gene:	W02A2.5 / 189098	WormBaseID:	WBGene00012190	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	495	Identity:	104/495 - (21%)
Similarity:	190/495 - (38%)	Gaps:	85/495 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 LVESIDTLIGNNQFQGYGVDLIKELADKLGFNF------TFRDGGNDYGSFNKTTNST-SGMLKE 491
            |..::|.:: ...|.|:.::::|.:.|.|.:..      |. .||.|:|:..|  |.| ||:|..
Worm    24 LFPTLDVIL-QCPFPGWTMEVLKMITDSLKWEIIPVVTPTI-VGGLDWGTLQK--NGTWSGVLGY 84

  Fly   492 IVEGRADLAITDLTITSEREEVIDFSIPFMNL-GIAILYVKPQKAPPALFSFMDPFSSEVWLYL- 554
            :..|.||........|..|.|..::|.|..|: .:.:...|.:.....|::...|||.||||.|
Worm    85 LQNGTADAVALMYQKTDTRNEYFEYSYPVTNVQPVFVARKKTETLGSVLWNAFKPFSVEVWLCLL 149

  Fly   555 ---------GIAYLGVSLCFFIIGRLSPIE--WDNPYPCIEEPEELENQFTINNSLWFTTGALLQ 608
                     .||..|:........|..|.|  |......::|..:....:|::.::.....||||
Worm   150 ASLVLNLLIMIAISGIEFKLLFRSRFRPWEMLWHVVQLQLDEKSDDMLFYTLSGNIVLFVFALLQ 214

  Fly   609 QGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDV--QYG 671
            .|                      |::..|...|...|...|..:|.       .|.|::  ..|
Worm   215 SG----------------------ILIEVYKGMLLTALITSNGDNPF-------ANADEMIKLIG 250

  Fly   672 AKRTGSTRNFFST--------SEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMEST 728
            .|:...|.|:...        |::..::.:.....::|.:...:....:|.|.|| ||.:.::..
Worm   251 EKKYHLTTNYMGNWYFDDLQHSDQQHFVSLRAATASNPVIPAASVSAALDLVDSG-KYIYPIQQD 314

  Fly   729 SIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNE--- 789
            |:.....:| ||...|.|.:.:........||:....:||..:  :..|..:.|..||::||
Worm   315 SLAMQMSKERCNYVYVSDGMPQVSSFFVFTKNFSGIAEFNTQI--IMNQAFIQRTFNKYFNEGFK 377

  Fly   790 ---VGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCD 851
               :.....:..:..|....|.::::.|::.:..:|...|:::       ||::....:.|..
Worm   378 LGFIPKCEVTEPTASDATKPLDIESVIGVFTIGALGVAASLMV-------FVFEIYHYWHVRI-- 433

  Fly   852 ALAEEFRIVIRFSENERPLKSAQSIYSRSRNSSQSIESLK 891
             ||...|  :|...|.|.|.....|:..:......|:.::
Worm   434 -LARRAR--MRDPWNVRNLARIAQIHFTTHEQYSDIDVMR 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377
		ANF_receptor	46..380	CDD:279440
		PBP2_iGluR_Kainate	417..788	CDD:270432	85/384 (22%)
		Lig_chan	549..819	CDD:278489	58/298 (19%)
W02A2.5	NP_502564.2	Lig_chan-Glu_bd	<36..86	CDD:214911	16/52 (31%)
W02A2.5	NP_502564.2	Periplasmic_Binding_Protein_Type_2	<74..>124	CDD:304360	15/51 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810