DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and glr-6

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_741822.2	Gene:	glr-6 / 180955	WormBaseID:	WBGene00001617	Length:	844	Species:	Caenorhabditis elegans

Alignment Length:	876	Identity:	240/876 - (27%)
Similarity:	424/876 - (48%)	Gaps:	97/876 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SIRLGLITDDATDR-IRQTFEHAISVVNNEL----GVPLVGETEQVAYGNSVQAF-AQLCRLMQS 91
            |||:||||....:. :|......:..:|.::    |...:..|..:|..||.:.. .::|.|..|
Worm    19 SIRIGLITSHHLEHSVRTAVNIIVPRINEQIVKTRGACFITHTSFIALKNSHEDLNTKICDLANS 83

  Fly    92 GVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSW-----GSNPDGFNLHPSPEDIANALYDIVN 151
            .|..:.|...|.:.|.:...|...:|.||  |..|     .......||:||.| .:..:..::|
Worm    84 EVSVIIGVVDRESGSIIEEQCAELNILFI--HYYWTPGYQKKQQTSLNLYPSME-YSQLMERLIN 145

  Fly   152 QFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSED------ 210
            .:.|..|::.|.:.:..|.|...::|.. |.|.:  :|.. .|:.:..:....:|.:.|
Worm   146 LWRWDNFVYIYSNYDAPKQLIETLSRLE-KSPAL--LRAH-TLDDSMMATALALRDTCDRNRCWP 206

  Fly   211 --SRIVVVGSTTGVAELLRQAQQVGIMNEDYTYII---GNLNLHTFDLEEYKYSEANITGIRMFS 270
              :|:::..|..........:.::|:::....::|   .:||.|   |.:|.::...:: :...|
Worm   207 KKNRVLIELSPNETLTFFDASLKLGMISVHNWFLITALDDLNDH---LSQYTHNGMRVS-LLTVS 267

  Fly   271 PDQEEVRDLMEKL---HQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSE 332
            .::....||..||   :||.....|.|..:.|  .:.|..:|::.:..:....     ::::|.
Worm   268 KEKWNQNDLAIKLPDMYQEYLAKIPSNPRTPF--KDFAFIFDSILLACQAGDR-----RIISCG- 324

  Fly   333 RHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEG-NVRKGFTFDVIELQTSGL-----VKVGTWE 391
                   |....:.:...:....|.:||:|.|.| :.|......:.|:..:|.     :...|||
Worm   325 -------DNEAVKKFKLPIVKPFKGLTGKISFNGTSDRSDSELHIWEMGITGAGLHTGIWKSTWE 382

  Fly   392 EGKDFEFQRPPQAVNF---NDIDDGSLVNKTFIVLISVATKPYASLVESI--DTLIGNNQFQGYG 451
            ..|:...    .|.|.   ::....|:.....:.:.|:..|||  ::|.|  |   |..:.:|:.
Worm   383 GSKELTM----LAKNIPGTHEHYQASVRESRTLKVTSIHEKPY--VIEKIMPD---GRIKHEGFC 438

  Fly   452 VDLIKELADKLGFNFTF---RDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEV 513
            |||:.:||:.|.||:|.   :|  |.||.....|:...||:.||:.|.||:|:..:|:|:.|.||
Worm   439 VDLLDKLAEMLHFNYTLKIVKD--NKYGERKNGTDEWDGMIGEILRGDADMAVAPITVTATRLEV 501

  Fly   514 IDFSIPFMNLGIAILYVKPQ-KAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWD 577
            |||:.||:.|||::|..:|. |:..:|..|:.|.|:.||.:..||.:..:|...:...||
Worm   502 IDFTDPFLQLGISMLMRQPNPKSSSSLTRFLWPLSASVWTFSAIATVITALLVTVAAVLS----- 561

  Fly   578 NPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANL 642
                    |:|...:|.|.||:|:....||:.||....:|.:||.|||:||.|||::::.||||.
Worm   562 --------PKESTAEFKIQNSVWYLVCILLRAGSGYNCQAGATRLISAVWWSFTLVLIAQYTANF 618

  Fly   643 AAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLME 706
            ||.||::..:.|.||.::|. |:.:..:|:...|||..||..|....:.::.|.: :|.|...:.
Worm   619 AALLTVDRKSMPFNSFEELG-NQTEYNFGSILGGSTMQFFKYSRIETFRRLWERMQSAEPSAFVG 682

  Fly   707 NNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGD-PLDEKGYGIAMVKNWPYRDKFNKAL 770
            .|.:||::|.: .||.|||||.::::...:.||||:||: .|...||.||:.|...:|:|..:.:
Worm   683 TNHEGVNRVLN-EKYVFLMESATLDYQVTQNCNLTRVGNVVLGSNGYSIALPKGSKWREKLTRQI 746

  Fly   771 LELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWC 835
            |:|.|:|::..|||.||.: ....|.:...:|..:.||.:|:.|::::|.:||.|.::.::|...
Worm   747 LDLNEKGIILMLKNNWWKK-SQQECQSSEPEDLQTALGAENVYGLFLLLALGSGIGVLCAVLEHT 810

  Fly   836 YFVY--KKAKNYEVPFCDALAEEFRIVIRFS 864
            :|::  |..:|.:.|....:.|.....||.|
Worm   811 HFIFFEKNKRNGQTPKLQQMIETIHAEIRNS 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	79/392 (20%)
		ANF_receptor	46..380	CDD:279440	69/359 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	136/378 (36%)
		Lig_chan	549..819	CDD:278489	92/271 (34%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	80/402 (20%)
glr-6	NP_741822.2	PBP2_iGluR_Kainate	409..764	CDD:270432	136/376 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020