DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and glr-7

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	897	Identity:	216/897 - (24%)
Similarity:	348/897 - (38%)	Gaps:	273/897 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 VIKVMRYDLNLNGNYKSVLRR---------IRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDY 239
            ||.:.|||.|.:.:..|:..:         :.:|.|       |.:.||||.| ..||..:..|.
Worm    11 VISLERYDFNDSSDINSLCDQMVNVSFVISVCRSND-------SISLVAELAR-ISQVPTIQVDL 67

  Fly   240 TYIIGNLNLH-----TFDLEEYK----------------YSEANITG------IRMFSPDQEEVR 277
            .|....||.:     |.....|.                :::.|||.      ..|:.||....|
Worm    68 NYWSLPLNFNGTSVPTISSPSYTTMVLSTLVFQNVITDIFADLNITPNSTVLYDNMYPPDFTAWR 132

  Fly   278 DLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQP--- 339
            |....|           .|..|:.||..:    :|:.|:.|:........|....:.:||:.
Worm   133 DAFSVL-----------PGIRFVPMETTV----LRMRAQITQLRMASINSLILVAKTENVERFTL 182

  Fly   340 --------------------------------------------------DGSTFRNYMRSLEIK 354
                                                              |...|||.: .||:
Worm   183 EAADFIEQRVFNTYVLTKDITAFKCDSCESAFMFWLRPFPVGKLMEIRDLDDYLFRNEI-GLEL- 245

  Fly   355 EKTITG----RIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVN--------- 406
            :.:|.|    .:.|..|| .|:.|:.|....:      |::....|..|..|...|
Worm   246 DYSINGWDSLNVAFYMNV-MGYAFETIRTMNA------TFDVLPTFTCQTGPSEPNITTTVRDII 303

  Fly   407 -------------------FNDID------------DGSLVNKTFIVL--ISVATKPYASL---- 434
                               |.|::            :.:|.||...|.  ||..:..|.:|
Worm   304 LNDPAHEYGNYTEAGLNMFFQDVEVRIYKIDRDRDHEDALFNKEVGVWSPISKLSVMYGTLQVDV 368

  Fly   435 ----VESIDTLI----------GNNQFQGYGVDLIKELADKLGFNFTF---RDGG----NDYGSF 478
                :..:.|||          .:..::||.:|||..:..::.|.:|.   .||.    :|.|::
Worm   369 RNLNIFRVVTLIQPPFVQRTGDPDTPYEGYCIDLINMIQVEVNFTYTIYEVEDGSFGTMDDNGNW 433

  Fly   479 NKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFM 543
            |       |::..:|.|.||:|:..|::.:|||..:||::|:.:|....:.:|......:||.||
Worm   434 N-------GLIGALVSGSADIALAPLSVMAERENDVDFTVPYYDLVGTTILMKKADVEYSLFKFM 491

  Fly   544 DPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELEN-----QFTINNSLWFTT 603
            ......|||.:..|||..|:..:|..|.||..:.|      ..|..:|     ||::...|||..
Worm   492 KVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSFTN------NKERYQNDIEKRQFSLKECLWFCM 550

  Fly   604 GALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDV 668
            .:|..||...|||.:|.|.::|.||.|..|:::|||||||||||:.....||:|:.||| .:..:
Worm   551 TSLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAAFLTVSRLEQPISSLDDLA-KQYKI 614

  Fly   669 QYGAKRTGSTRNFF---STSEEPIY-----IKMNEYLNA----------HP-------------- 701
            :|...:..::..:|   :..||..|     :.:||.::.          :|
Worm   615 EYAPIKGSASETYFRRMAEIEETFYNMWKEMSLNESMSPRDRAKLAVWDYPVSDKFTNMWRYMQE 679

  Fly   702 EMLMENNQQGVDKV-KSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDK 765
            ..|..|....||:| .|...:||:.::|.|::..:..|||.:||.....|.|.||:......:||
Worm   680 SKLPVNMDTAVDRVLNSVDGFAFIGDATEIKYAALTNCNLQQVGTEFSRKPYAIAVQSGHILKDK 744

  Fly   766 FNKALLELQEQGVLARLKNKWW----NEVGAGVCSAKSDD-DGPSELGVDNLSGIYVVLVIGSII 825
            .:.|:|.|..:..|..||.|||    |:|.   |...||: ||   :.:.|:.|:::|::.|..:
Worm   745 ISSAILMLLNERRLETLKEKWWTDNPNKVS---CPDSSDESDG---ISIQNIGGVFIVILAGIAL 803

  Fly   826 SIIISILCWCYFVYK-KAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSI 876
            ||:  .|.:.|:.|| ||:.        .||:       .:.|..:|.:|.:
Worm   804 SIV--TLAFEYYYYKRKARK--------AAEK-------EQEELEMKQSQQV 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	57/305 (19%)
		ANF_receptor	46..380	CDD:279440	56/288 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	128/439 (29%)
		Lig_chan	549..819	CDD:278489	96/312 (31%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556	19/132 (14%)
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	120/407 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810