DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and glr-5

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	888	Identity:	250/888 - (28%)
Similarity:	426/888 - (47%)	Gaps:	128/888 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 AFAQLCRLMQSG-VGAVFGPAARHTASHLLNACDSKDIPFI--YPHLSWGSNPDGFNLHPSPEDI 142
            |..:.|::::.. :.|:.|.:.....:.|....|..||||:  ...|.........:..|.|: :
Worm    74 AIKKACKMLEKDHIVALLGGSHAALNAQLERITDDLDIPFLTAIDDLRTDMGKSKIDFWPRPQ-L 137

  Fly   143 ANALYDIVNQFEWSRFIFCYESAEYLKILDHLM--TRY-GIKGPVIKVMRYDLNLNGNYKSVLRR 204
            ..|:.|:...:.|:|.:..||..|.::.|:.|:  ..| .|:..:|||.      :|:|....|:
Worm   138 FEAVVDMFTHWRWNRIVLVYEGDERIRRLEQLLESEEYASIRFYLIKVH------DGDYMKAARQ 196

  Fly   205 IRK------------SEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYK 257
            :::            ||.||::|..:.......|..:.|:|::...:.:::.|:.|.|.|:|.::
Worm   197 VKELEECRLLHKKDCSEFSRLLVDMNPEHTYTFLLASLQMGLIELKHWFLLTNMELSTMDMELFR 261

  Fly   258 YSEANITGIRMFSP---DQ---EEVRDLMEKLH--QELGE--SEPVNSGSTFITMEMALTYDAV- 311
            |:.|     |..||   |.   .|.||.....|  :.:.|  :...::......||...|:|||
Worm   262 YNHA-----RFISPYPVDSTFLTENRDAFNFSHFKEHITEKWAMKTDNSRNLKMMEAVFTFDAVY 321

  Fly   312 ---RVIAETTKHLPYQ--PQMLNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIY-FEGNVRK 370
               .|..|.:.|:...  ||.| |.:...|       .|.|.....:.:..:...:: ..|::|:
Worm   322 AFANVFNELSSHMQMNDVPQTL-CRKSSRN-------SRKYQHGRSLIDNIVHNDLHGLSGDLRR 378

  Fly   371 --------GFTFDVIELQTSG-LVKVGTWEEGKDFEFQRPPQAVNFNDIDDG----------SLV 416
                    .|:..:..|..|| |..:|.||         |...|:.|...|.          |..
Worm   379 LNGHPLKSNFSMRIQLLGYSGRLDDIGFWE---------PATNVHVNMSGDSKAQLQRNVQVSDE 434

  Fly   417 NKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTF---RDG--GND-Y 475
            .|....:.::..:||..|.::...|..|::|:|:.:||:.||:..|||.:|.   :||  ||| |
Worm   435 LKPHFRVTTIMERPYVMLKKNHYELDANSKFEGFCIDLLAELSKDLGFTYTIHAVKDGKYGNDKY 499

  Fly   476 GSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALF 540
            |:     .|..||:.||:.|.|::|:..||:...|.|.:||:.||::|||:|||..|....|.||
Worm   500 GN-----GSWDGMMGEILRGEAEMAVAPLTVNYRRSEAVDFTKPFLSLGISILYKVPDDQQPDLF 559

  Fly   541 SFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWD---------NPYPCI------EEPEELE 590
            ||::|.|.::|..:..:.:.|:|..:.:..::|.||:         .|:|..      |.|..:.
Worm   560 SFLNPLSWQIWTAIATSIITVTLGMYFVANVTPYEWNLNFSCCTAHEPHPAAAFATNQEAPIVMS 624

  Fly   591 NQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPI 655
            |.::..|::|:....:|:.|.:..|:|:|||.:...||.|.|:::|:|||||||.||:..|..||
Worm   625 NNYSFWNTVWYVLSTMLKGGCDFGPRAVSTRLLGGTWWVFYLVIISAYTANLAAVLTVSRPYIPI 689

  Fly   656 NSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTK 720
            .::.||| |:..:.||..|.|||..||..|....::||.:|:. ..::.:.:|.:||::..| ..
Worm   690 KNLDDLA-NQTTISYGTIRGGSTMQFFQESRIAAHVKMWQYMK-DKDVFVTSNGKGVERALS-MN 751

  Fly   721 YAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNK 785
            ||:||||||:|:.|.:.||||::|..|..||||||:.|...:.|:.::.:|...::|::...|.|
Worm   752 YAYLMESTSLEYETQQNCNLTQIGGVLGSKGYGIALAKKSEWTDRISRQILLYAKRGIIEMKKTK 816

  Fly   786 WWNEVGAGVCS-AKSDDDGPSELGVDNLSGIYVVLVIGSIIS---IIISILCWCYFVYKKAKNYE 846
            ||...||...| |.:.......|.:.|::|:::.|.:|.:::   :|..::..|:.:.||...
Worm   817 WWRSKGAACASTASAVKHDRFALSMYNVAGLFITLGVGIVLAAIVVIFELIHRCHHIAKKEGK-- 879

  Fly   847 VPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSSQSIES 889
             ||.:.|..|    :||:.|...|..     .|||....:..|
Worm   880 -PFLEELLYE----LRFALNMNSLSD-----HRSRQKMSTCNS 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	80/359 (22%)
		ANF_receptor	46..380	CDD:279440	73/341 (21%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	139/391 (36%)
		Lig_chan	549..819	CDD:278489	94/285 (33%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	83/372 (22%)
		ANF_receptor	38..377	CDD:279440	71/322 (22%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	138/388 (36%)
		Lig_chan	568..855	CDD:278489	95/289 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I4290
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.780