DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and glr-2

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001021114.1	Gene:	glr-2 / 175999	WormBaseID:	WBGene00001613	Length:	977	Species:	Caenorhabditis elegans

Alignment Length:	882	Identity:	268/882 - (30%)
Similarity:	420/882 - (47%)	Gaps:	163/882 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 SNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDL 192
            :||..|::.||.|.:   |.|.:....|...::.::.....:.|..:.:....|.|     :|.|
Worm   137 NNPMIFSVAPSAEQL---LIDYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSP-----KYQL 193

  Fly   193 NLNGNY---------KSVL----RRIR-----KSEDSR-----------IVVVGSTTGVAELLRQ 228
            .:: ||         |..|    |||.     ||.||.           ||.:..:......||.
Worm   194 FVD-NYVAPSDEEMFKEFLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRA 257

  Fly   229 AQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQEL--GESE 291
            .::..::.::|.|:..|.::...||..:.:|..|||..|:|..:.::......:.|...  |.|
Worm   258 LEESVLVKKEYHYVFSNFDVDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYRGGFS- 321

  Fly   292 PVNSGSTFITMEMALTYDAVRVIAET-----------------TKHLPYQPQMLN-------CSE 332
              |:.|  |....|..:||:.|..:.                 .:|     |:.|       |..
Worm   322 --NTDS--IPTAAAFAHDAILVAGKALQIAMNEHGKGIFDKSFVRH-----QLFNRGRKGLYCRP 377

  Fly   333 RHDNVQPDGSTFRNYMRSLEI-----------KEKTITGRIYFE--GNVRKGFTFDVIELQTSGL 384
            ..|  |.:...|..:....:|           |:.|:||||.|:  ...|..|:.:::|:: .|:
Worm   378 HED--QTESRQFETFEHGKKIAEAIKKVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIK-PGV 439

  Fly   385 VKVGT------WEEGKDF----EFQRPPQAVNFNDIDDGSLVNKTFIV---LISVATKPYASLVE 436
            ..:.:      |.||:.|    |.....:..:.:....|.|.:|.:.:   :::|..||:..|..
Worm   440 NSLNSIWERFQWAEGEGFLLGGERYVQEKKKDSSQTRKGILPSKPWQLRFNVVTVLVKPFVMLKR 504

  Fly   437 ---SIDTLIGNNQFQGYGVDLIKELADKL-GFNF-TFRDGGNDYGSFNKTTNSTSGMLKEIVEGR 496
               ....|.||::|:||.:||:..||..: ||.: .|...||.||| .:...|..||:..::...
Worm   505 RNPGEPELKGNDRFEGYCIDLLNLLAKNITGFEYDVFISDGNKYGS-RQADGSWDGMIGYLLNET 568

  Fly   497 ADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGV 561
            ||:|:..||||.|||..:|||.|||..||:|:..||:|....:||||:|....:|::...:|.||
Worm   569 ADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGV 633

  Fly   562 SLCFFIIGRLSPIEWDNPYPCIEEPEELE-------NQFTINNSLWFTTGALLQQGSEIAPKALS 619
            ||..|:      :.|.:||   |:..|.:       |:||:.||||||..|.:|||::|.|:|:|
Worm   634 SLTIFL------VSWFSPY---EKRIEFKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDILPRAVS 689

  Fly   620 TRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFST 684
            .|..|:.|||||||:|||||||||||||:|..|.||.||:||| |::.:.||....|||..||..
Worm   690 GRIASSCWWFFTLIIVSSYTANLAAFLTLERMTPPIESVEDLA-NQNKILYGVNEGGSTAAFFED 753

  Fly   685 SEEPIYIKMNEYLNAHPEMLMENNQQ-----------------GVDKVK-SGTKYAFLMESTSIE 731
            |..|:|.||..::.:..:..:|..:|                 |::||: |..|||||:|.|:..
Worm   754 SIVPLYKKMWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYADGIEKVRTSKGKYAFLLEETTNN 818

  Fly   732 FNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVC 795
            :.:.|. |:..|||..|:..|||||.....|.|...|.|:|.|.|:|.|.:|:||||.:  .|.|
Worm   819 YESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKGELKKLENKWWYD--RGQC 881

  Fly   796 SAKSDDDG-PSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRI 859
            ...:.|.| .|.|.:..::||:.:|:.|.::|:..:::   .|:::|.|...        |:.|.
Worm   882 DTGTSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALV---EFLFRKNKENR--------EKERN 935

  Fly   860 VIRFSENERPLKSAQSIYSRSRNSSQSIESLKTDSEE 896
            .:|.|   ||||.. .:.|..|...:.:::.:|.|||
Worm   936 RMRSS---RPLKPG-ILASCERAKQKQLQNRRTKSEE 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	73/346 (21%)
		ANF_receptor	46..380	CDD:279440	68/319 (21%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	163/404 (40%)
		Lig_chan	549..819	CDD:278489	119/296 (40%)
glr-2	NP_001021114.1	Periplasmic_Binding_Protein_Type_1	7..453	CDD:299141	70/337 (21%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:304360	161/394 (41%)
		Lig_chan	621..910	CDD:278489	120/300 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920