Protein Alignment GluRIID and Grin2b

DIOPT Version :9

• Sequence 1: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: NP_001350679.1
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 943
• Identity: 208/943 - (22%)
• Similarity: 391/943 - (41%)
• Gaps: 217/943 - (23%)

  Fly     5 WISLIILSLSRVQAQFYGGNAYEASSGQSIRLGLITDDATDRI-------RQTFEHAISVVNNEL 62
            |:.|.:|::|       |..|....|..||.:.:|....:|.:       :..|.|...|...||
Mouse    13 WLVLAVLAVS-------GSKARSQKSAPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVEL 70

  Fly    63 -------------------------GVPLVGETEQVAYGNSVQAFAQLCRLMQS-------GVGA 95
                                     ||....:|:|       :|.||:...:.:       |:
Mouse    71 VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQ-------EAIAQILDFISAQTLTPILGI-- 126

  Fly    96 VFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIF 160
                   |..|.::.|  .||...::           |...||.|..|:.:.:|:.:::|  :||
Mouse   127 -------HGGSSMIMA--DKDESSMF-----------FQFGPSIEQQASVMLNIMEEYDW--YIF 169

  Fly   161 CYESAEYLKILDHL-MTRYGIKGPVI-----KVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGST 219
            ...:..:....|.: ..|..|:...:     :|:..|::|:.....:..:::|.:...|::..:.
Mouse   170 SIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTK 234

  Fly   220 TGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLH 284
            .....:...|..||:....||:|:.:|.....|....::.    ||:...|.|:
Mouse   235 EEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFP----TGLISVSYDE----------- 284

  Fly   285 QELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMR 349
            .:.|....|..|...||..      |..:::|.: .:| :|:. :|...|:......:....|:.
Mouse   285 WDYGLPARVRDGIAIITTA------ASDMLSEHS-FIP-EPKS-SCYNTHEKRIYQSNMLNRYLI 340

  Fly   350 SLEIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLV----------KVGTWEEGKDFEFQR---- 400
            :           :.|||. ...|:.|..::....::          :||.|   ||...|.
Mouse   341 N-----------VTFEGR-NLSFSEDGYQMHPKLVIILLNKERKWERVGKW---KDKSLQMKYYV 390

  Fly   401 -PPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTL---------------IGNNQ--- 446
             |.......:.:|..|      .::::...|:. :|||:|.|               |..|:
Mouse   391 WPRMCPETEEQEDDHL------SIVTLEEAPFV-IVESVDPLSGTCMRNTVPCQKRIISENKTDE 448

  Fly   447 --------FQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNST-SGMLKEIVEGRADLAIT 502
                    .:|:.:|::|:::..:.|.:......|  |...|..|.| :||:.|:|..||.:|:.
Mouse   449 EPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN--GKHGKKINGTWNGMIGEVVMKRAYMAVG 511

  Fly   503 DLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVS-LCFF 566
            .|||..||.||:|||:||:..||::: |.......:..:|::|||::||:.:.:..|.|| :..|
Mouse   512 SLTINEERSEVVDFSVPFIETGISVM-VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVF 575

  Fly   567 IIGRLSPIEWDNPYPCIEEPEELEN-QFTINNSLWFTTGALLQQGSEIA-PKALSTRTISAIWWF 629
            :....||:.::.   |:.:..|... .|||..::|...|.:......:. ||..:::.:.::|.|
Mouse   576 VFEYFSPVGYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAF 637

  Fly   630 FTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNK--------DDVQYGAKRTGST-RNFFSTS 685
            |.:|.::|||||||||:..|   ..::.|..|:|.|        ...::|....||| ||..:.
Mouse   638 FAVIFLASYTANLAAFMIQE---EYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN- 698

  Fly   686 EEPIYIKMNEYLNAHPEMLMENNQQGVD----KVKSGTKYAFLMESTSIEFNTVRE--CNLTKVG 744
                |.:|:.|:.       :.||:|||    .:|:|...||:.::..:.:...|:  |.|..:|
Mouse   699 ----YAEMHAYMG-------KFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIG 752

  Fly   745 D--PLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSEL 807
            .  .....|||||:.|:..::.:.:.|:|:|...|.:..|:..|.    .|:|..:.::...|:|
Mouse   753 SGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL----TGICHNEKNEVMSSQL 813

  Fly   808 GVDNLSGIYVVLVIGSIISIIISILCWCYFVYK 840
            .:||::|::.:|.....:| :|:.:|...|.::
Mouse   814 DIDNMAGVFYMLGAAMALS-LITFICEHLFYWQ 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	71/416 (17%)
		ANF_receptor	46..380	CDD:279440	64/378 (17%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	112/417 (27%)
		Lig_chan	549..819	CDD:278489	76/289 (26%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	74/424 (17%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	116/431 (27%)
		NMDAR2_C	840..1482	CDD:402274	1/6 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840