Protein Alignment GluRIID and Grin2a

DIOPT Version :9

• Sequence 1: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 963
• Identity: 211/963 - (21%)
• Similarity: 388/963 - (40%)
• Gaps: 209/963 - (21%)

  Fly    53 HAISVVNNEL----------GVPLVGETEQVAY----GNSVQAFAQLCRLMQSGV---GAVFG-P 99
            |:..|...||          |:||  :...||.    .:.......:|.|| ||.   |.||| .
Mouse    42 HSHDVTERELRNLWGPEQATGLPL--DVNVVALLMNRTDPKSLITHVCDLM-SGARIHGLVFGDD 103

  Fly   100 AARHTASHLLNACDSKD-IPFIYPH-----LSWGSNPDG--FNLHPSPEDIANALYDIVNQFEWS 156
            ..:...:.:|:...|:. ||.:..|     :....:|..  |....|.:..|..:..|:..::|.
Mouse   104 TDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWH 168

  Fly   157 RF-----IF-CYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVV 215
            .|     || .|.  :::..:...:....:...:..|:..|.:.......|  :::|...|.|::
Mouse   169 VFSLVTTIFPGYR--DFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQV--QLKKIHSSVILL 229

  Fly   216 VGSTTGVAELLRQAQQVGIMNEDYTYIIGNL--------------NLHTFDLEEYKYS-EANI-T 264
            ..|......:|.:|:.:|:...|:.:|:.:|              .|.:...:::.|| ||.: .
Mouse   230 YCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRD 294

  Fly   265 GIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLN 329
            |:.:.:   .....::||.              ::|....|..|..... .||..|..:|..:
Mouse   295 GLGILT---TAASSMLEKF--------------SYIPEAKASCYGQTEK-PETPLHTLHQFMV-- 339

  Fly   330 CSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGK 394
                  ||..||..........::..:.:.                ::..:.....|||.| |.:
Mouse   340 ------NVTWDGKDLSFTEEGYQVHPRLVV----------------IVLNKDREWEKVGKW-ENQ 381

  Fly   395 DFEFQRP--PQAVNFNDI--DDGSLVNKTFIVLISVATKPYASLVESIDTL-------------- 441
            ....:..  |:..:|:|.  ||..|      .::::...|:. :||.||.|
Mouse   382 TLSLRHAVWPRYKSFSDCEPDDNHL------SIVTLEEAPFV-IVEDIDPLTETCVRNTVPCRKF 439

  Fly   442 --IGNNQ---------FQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNST-SGMLKEIVE 494
              |.|:.         .:|:.:|::|:|:..:.|.:......|  |...|..|:. :||:.|:|.
Mouse   440 VKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTN--GKHGKKVNNVWNGMIGEVVY 502

  Fly   495 GRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYL 559
            .||.:|:..|||..||.||:|||:||:..||::: |.......:..:|::|||:.||:.:.:..|
Mouse   503 QRAVMAVGSLTINEERSEVVDFSVPFVETGISVM-VSRSNGTVSPSAFLEPFSASVWVMMFVMLL 566

  Fly   560 GVS-LCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIA-PKALSTRT 622
            .|| :..|:....||:.::......:.|.  ...|||..::|...|.:......:. ||..:::.
Mouse   567 IVSAIAVFVFEYFSPVGYNRNLAKGKAPH--GPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKI 629

  Fly   623 ISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLA-----DNKDDVQYGAKRTGST-RNF 681
            :.::|.||.:|.::|||||||||:..|.....:..:.|..     |.....::|....||| ||.
Mouse   630 MVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNI 694

  Fly   682 FSTSEEPIYIKMNEYLNAHPEMLMENNQQGVD----KVKSGTKYAFLMESTSIEFNTVRE--CNL 740
            .:.     |..|::|:.       :.||:||:    .:|:|...||:.::..:.:...|:  |.|
Mouse   695 RNN-----YPYMHQYMT-------KFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKL 747

  Fly   741 TKVGDP--LDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDG 803
            ..:|..  ....|||||:.|..|::.:.:.|||:....|.:..|:..|.    .|:|..:.::..
Mouse   748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL----TGICHNEKNEVM 808

  Fly   804 PSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFC------------------ 850
            .|:|.:||::|::.:|.....:|:|..|  |.:..|.|.:     ||
Mouse   809 SSQLDIDNMAGVFYMLAAAMALSLITFI--WEHLFYWKLR-----FCFTGVCSDRPGLLFSISRG 866

  Fly   851 ------------DALAEEFRIVIRFSENERPLKSAQSIYSRSRNSSQSIESLK 891
                        ...:.:|.:....|...:.|:||::|.:.|..:|..::|.|
Mouse   867 IYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISNMSNMNSSRMDSPK 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	70/391 (18%)
		ANF_receptor	46..380	CDD:279440	65/374 (17%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	109/412 (26%)
		Lig_chan	549..819	CDD:278489	73/285 (26%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	70/399 (18%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	113/426 (27%)
		HisJ	<458..>541	CDD:223904	31/85 (36%)
		Lig_chan	556..828	CDD:278489	74/289 (26%)
		NMDAR2_C	839..1464	CDD:287527	14/86 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840