Protein Alignment GluRIID and Grid1

DIOPT Version :10

• Sequence 1: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: NP_032192.2
• Gene: Grid1 / 14803
• MGIID: 95812
• Length: 1009
• Species: Mus musculus
• Alignment Length: 869
• Identity: 214/869 - (24%)
• Similarity: 409/869 - (47%)
• Gaps: 111/869 - (12%)

  Fly    34 IRLGLITDDATDRIRQTFEHAIS--VVNNELGVPLVGETEQVAY-------GNSVQAFAQLCRLM 89
            |.:|.|.::...:..:.|:.|:|  .:|::     :.::|::.|       .|..||..:.|.||
Mouse    24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDD-----ILQSEKITYSIKVIEANNPFQAVQEACDLM 83

  Fly    90 QSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNP-DGFNLHPSPEDIA---------- 143
            ..|:.|:.......:|:.|.:..|:..||.::...:.|.:| ...:|:|||:..|
Mouse    84 TQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVR 148

  Fly   144 --NALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIR 206
              :.:..:|.:..|.:|:..|:|...::.|...:.:....|..:.:.:.|.|::..:.|:...::
Mouse   149 LNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMK 213

  Fly   207 KSE-----DS--RIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSE-ANI 263
            ..|     |:  |.:::.|..|....:.:|.:..:.::|..::..|..:...::.:..:|. ..:
Mouse   214 TEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRM 278

  Fly   264 TGIRMFSPDQEEVRDLMEKLHQELG-ESEPVNSGSTFITMEMALTYDAVRVIA-------ETTKH 320
            |.:|...|..::.:..|...|:... ..:|.......:.:.....||:|.::|       |..|.
Mouse   279 TVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKW 343

  Fly   321 LPYQPQMLNCSERHDNVQPDGSTFRNYMRS---------LEIKEKTITGRIYFEGNVRKGFTFDV 376
              :....|||..:.......|.:..:.::.         :|.:|.:....:.||   ..|.|:.
Mouse   344 --HSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFE---ILGTTYS- 402

  Fly   377 IELQTSG--LVKVGTW--EEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVES 437
               :|.|  :.|:.||  |:|.:...|..|.         ||.:....:.:::|..:|:..:.|:
Mouse   403 ---ETFGKDMRKLATWDSEKGLNGSLQERPM---------GSRLQGLTLKVVTVLEEPFVMVAEN 455

  Fly   438 IDTLIGN-NQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNSTS--GMLKEIVEGRADL 499
            |   :|. .:::|:.:|::..||..|||.:......:  |.:....::||  ||:.|::..||||
Mouse   456 I---LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPD--GRYGHQLHNTSWNGMIGELISKRADL 515

  Fly   500 AITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLC 564
            ||:.:|||.|||.|:|||..:|:..:.||..||:: ..::||...||...||..:..|...|.:.
Mouse   516 AISAITITPERESVVDFSKRYMDYSVGILIKKPEE-KISIFSLFAPFDFAVWACIAAAIPVVGVL 579

  Fly   565 FFIIGRLSPIEWDN---PYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAI 626
            .|::.|:..:...:   |.|....        |:::::|...||.:|||.|.:..:::.|.:...
Mouse   580 IFVLNRIQAVRSQSATQPRPSASA--------TLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGS 636

  Fly   627 WWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFST------S 685
            ||.||||:.||||||||||||:....:||.:.:||: .:.::.||..|..:...:|..      .
Mouse   637 WWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLS-KQLEMSYGTVRDSAVYEYFRAKGTNPLE 700

  Fly   686 EEPIYIKMNEYL--NAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFN--TVRECNLTKVGDP 746
            ::..:.::...:  |...:..:.|..:|:.|.|.| .||||.:...:|:.  |..:|::|.:|:.
Mouse   701 QDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKG-NYAFLWDVAVVEYAALTDDDCSVTVIGNS 764

  Fly   747 LDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSE---LG 808
            :..||||||:....||||.|::.:||||:.|.|..||.|||...|.  |...|.....:|   |.
Mouse   765 ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGR--CDLTSHSSTQTEGKSLK 827

  Fly   809 VDNLSGIYVVLVIGSIISIIISIL 832
            :.:.:|::.:|.||.:::.:::.|
Mouse   828 LHSFAGVFCILAIGLLLACLVAAL 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..400	CDD:380605	76/415 (18%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	122/386 (32%)
		Lig_chan	547..819	CDD:459656	86/287 (30%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269|PubMed:27418511	21..436		81/434 (19%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	76/413 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	122/385 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960