DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Grid1

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	869	Identity:	214/869 - (24%)
Similarity:	409/869 - (47%)	Gaps:	111/869 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRLGLITDDATDRIRQTFEHAIS--VVNNELGVPLVGETEQVAY-------GNSVQAFAQLCRLM 89
            |.:|.|.::...:..:.|:.|:|  .:|::     :.::|::.|       .|..||..:.|.||
Mouse    24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDD-----ILQSEKITYSIKVIEANNPFQAVQEACDLM 83

  Fly    90 QSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNP-DGFNLHPSPEDIA---------- 143
            ..|:.|:.......:|:.|.:..|:..||.::...:.|.:| ...:|:|||:..|
Mouse    84 TQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVR 148

  Fly   144 --NALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIR 206
              :.:..:|.:..|.:|:..|:|...::.|...:.:....|..:.:.:.|.|::..:.|:...::
Mouse   149 LNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMK 213

  Fly   207 KSE-----DS--RIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSE-ANI 263
            ..|     |:  |.:::.|..|....:.:|.:..:.::|..::..|..:...::.:..:|. ..:
Mouse   214 TEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRM 278

  Fly   264 TGIRMFSPDQEEVRDLMEKLHQELG-ESEPVNSGSTFITMEMALTYDAVRVIA-------ETTKH 320
            |.:|...|..::.:..|...|:... ..:|.......:.:.....||:|.::|       |..|.
Mouse   279 TVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKW 343

  Fly   321 LPYQPQMLNCSERHDNVQPDGSTFRNYMRS---------LEIKEKTITGRIYFEGNVRKGFTFDV 376
              :....|||..:.......|.:..:.::.         :|.:|.:....:.||   ..|.|:.
Mouse   344 --HSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFE---ILGTTYS- 402

  Fly   377 IELQTSG--LVKVGTW--EEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVES 437
               :|.|  :.|:.||  |:|.:...|..|.         ||.:....:.:::|..:|:..:.|:
Mouse   403 ---ETFGKDMRKLATWDSEKGLNGSLQERPM---------GSRLQGLTLKVVTVLEEPFVMVAEN 455

  Fly   438 IDTLIGN-NQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNSTS--GMLKEIVEGRADL 499
            |   :|. .:::|:.:|::..||..|||.:......:  |.:....::||  ||:.|::..||||
Mouse   456 I---LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPD--GRYGHQLHNTSWNGMIGELISKRADL 515

  Fly   500 AITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLC 564
            ||:.:|||.|||.|:|||..:|:..:.||..||:: ..::||...||...||..:..|...|.:.
Mouse   516 AISAITITPERESVVDFSKRYMDYSVGILIKKPEE-KISIFSLFAPFDFAVWACIAAAIPVVGVL 579

  Fly   565 FFIIGRLSPIEWDN---PYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAI 626
            .|::.|:..:...:   |.|....        |:::::|...||.:|||.|.:..:::.|.:...
Mouse   580 IFVLNRIQAVRSQSATQPRPSASA--------TLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGS 636

  Fly   627 WWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFST------S 685
            ||.||||:.||||||||||||:....:||.:.:||: .:.::.||..|..:...:|..      .
Mouse   637 WWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLS-KQLEMSYGTVRDSAVYEYFRAKGTNPLE 700

  Fly   686 EEPIYIKMNEYL--NAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFN--TVRECNLTKVGDP 746
            ::..:.::...:  |...:..:.|..:|:.|.|.| .||||.:...:|:.  |..:|::|.:|:.
Mouse   701 QDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKG-NYAFLWDVAVVEYAALTDDDCSVTVIGNS 764

  Fly   747 LDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSE---LG 808
            :..||||||:....||||.|::.:||||:.|.|..||.|||...|.  |...|.....:|   |.
Mouse   765 ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGR--CDLTSHSSTQTEGKSLK 827

  Fly   809 VDNLSGIYVVLVIGSIISIIISIL 832
            :.:.:|::.:|.||.:::.:::.|
Mouse   828 LHSFAGVFCILAIGLLLACLVAAL 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	76/412 (18%)
		ANF_receptor	46..380	CDD:279440	67/380 (18%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	122/386 (32%)
		Lig_chan	549..819	CDD:278489	86/285 (30%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		81/434 (19%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	76/411 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	122/385 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740