DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and Gria4

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	900	Identity:	304/900 - (33%)
Similarity:	471/900 - (52%)	Gaps:	90/900 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SIRLGLITDDATDRIRQTFEHAISVVN-----NELGVPLVGETEQVAYGNSVQAFAQLCRLMQSG 92
            |:::|.:....||:....|..||.:.|     :|....||...:.:...||.......|.....|
Mouse    26 SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRG 90

  Fly    93 VGAVFGPAARHTASHLLNACDSKDIPFIYPHL-SWGSNPDGFNLHPSPEDIANALYDIVNQFEWS 156
            |.|:||...:.:...|.:.|.:..|..|.|.. :.|.:.....|.||   :..||..:::.:||:
Mouse    91 VFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPS---LRGALLSLLDHYEWN 152

  Fly   157 RFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNG-NYKSVLRRIRKSEDSRIVVVGSTT 220
            .|:|.|::.....||..:|.:.|..|..:..:..: |.|. :|:.:|..:.:.::.:.|:.....
Mouse   153 CFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVE-NFNDVSYRQLLEELDRRQEKKFVIDCEIE 216

  Fly   221 GVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMF---SPDQEEVRDLMEK 282
            .:..:|.|...||...:.|.|||.||......||.:.:..||:||.::.   :|...::.|..:|
Mouse   217 RLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKK 281

  Fly   283 LHQE--LGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSER-------HDNVQ 338
            |.|.  .|...|....|       |||||.|.|:|||.:.|  :.|.::.|.|       .:...
Mouse   282 LDQREYPGSETPPKYTS-------ALTYDGVLVMAETFRSL--RRQKIDISRRGNAGDCLANPAA 337

  Fly   339 PDGSTFRNYMRSLEIKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEE-GKDFEFQRP 401
            |.|..........:::.:.:||.:.|:...|: .:|.||.||:::|..|||.|.: .|....|..
Mouse   338 PWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDA 402

  Fly   402 PQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNF 466
            |...|    |..::.|:| :|:.::...||....::.:...||::::||.|||..|:|..:|..:
Mouse   403 PTLGN----DTAAIENRT-VVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKY 462

  Fly   467 TFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAIL 528
            ...   ||  .||:.:..|...:||:.|:|.|:|::||..||||..||||||||.|||:|||:|:
Mouse   463 KIAIVPDG--KYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIM 525

  Fly   529 YVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELE--- 590
            ..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||..     ||||:.:
Mouse   526 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEPEDGKEGP 585

  Fly   591 -----NQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIEN 650
                 |:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||:|.
Mouse   586 SDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 650

  Fly   651 PTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVDK 714
            ..|||.|.:||| .:.::.||...:|||:.||..|:..:|.||..|: :|.|.:......:||.:
Mouse   651 MVSPIESAEDLA-KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVAR 714

  Fly   715 V-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQG 777
            | ||..|:|||:|||..|:...|: |:..|||..||.||||:|..|....|...|.|:|:|.|.|
Mouse   715 VRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAG 779

  Fly   778 VLARLKNKWWNEVGAGVCSAK--SDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYK 840
            ||.:||||||.:  .|.|..|  ...|..|.|.:.|::|::.:||.|..::::::::.:||....
Mouse   780 VLDKLKNKWWYD--KGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRA 842

  Fly   841 KAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSSQSIESLKTDSE 895
            :||..:|                      .||||:.   :..|||:..:|.|..|
Mouse   843 EAKRMKV----------------------AKSAQTF---NPTSSQNTHNLATYRE 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	99/382 (26%)
		ANF_receptor	46..380	CDD:279440	89/353 (25%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	173/384 (45%)
		Lig_chan	549..819	CDD:278489	125/282 (44%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	99/384 (26%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	175/391 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750