DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GRIN3A

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	861	Identity:	189/861 - (21%)
Similarity:	337/861 - (39%)	Gaps:	220/861 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 IPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKILD------HLM 175
            :||..|...|.|:|..|        :.:..:.:|.|...:...|.....|.:: ||      |:
Human   164 LPFSSPSSPWSSDPFSF--------LQSVCHTVVVQGVSALLAFPQSQGEMME-LDLVSLVLHI- 218

  Fly   176 TRYGIKGPVIKVMRYD--------LNLNGNYKSVLRRIRKSEDSRIVV----------------- 215
                   |||.::|::        |:|..:.::.|     |.|:.:.|
Human   219 -------PVISIVRHEFPRESQNPLHLQLSLENSL-----SSDADVTVSILTMNNWYNFSLLLCQ 271

  Fly   216 -------------------VGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEA 261
                               :||...:...|...|.:             |:.....||..|.|..
Human   272 EDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDL-------------LSFLQIQLESIKNSTP 323

  Fly   262 NITGIRMFSPDQEEVRDLME----------KLHQELGESEPVNS-------------GST----- 298
            .:.   ||..|.|.:|.:.|          :|...||:|:.|..             |.|
Human   324 TVV---MFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVF 385

  Fly   299 --FITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDG---------STFRNYMRSLE 352
              ::...|.|...||.........|...|..:||.|........|         :|||....|:.
Human   386 EHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIR 450

  Fly   353 IKEKTITGRIYFEGNVRKGFTFDVIELQTSGL-----VKVGTWEEGK---DF------------E 397
            :|..||   :..|.|      |.:..||...:     .::|:|:.||   |:            .
Human   451 VKGSTI---VSSENN------FFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTH 506

  Fly   398 FQRPPQA------------VNFNDIDDGSLVNKTFIVL------ISVATKPYASLVESIDTLIGN 444
            ||.|.:.            |...::||..|.....:.|      .|.....::||..|.||:  .
Human   507 FQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTV--P 569

  Fly   445 NQFQ----GYGVDLIKELADKLGFNF-TFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDL 504
            .:|:    ||.:||::::|:.:.|:| .:..|...||::.  ....:|::.:::.|.|.:|:|..
Human   570 IKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLRGTAHMAVTSF 632

  Fly   505 TITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIG 569
            :|.:.|.:||||:.||.:..:.|| |:.:.....:.:||.|....:||.:.:| |.::..|
Human   633 SINTARSQVIDFTSPFFSTSLGIL-VRTRDTAAPIGAFMWPLHWTMWLGIFVA-LHITAVF---- 691

  Fly   570 RLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIA---PKALSTRTISAIWWFFT 631
             |:..||.:|:....:.......|:.:::|......|.  |..:|   ||..:.|.:..:|..|.
Human   692 -LTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLF--GRTVAIKPPKCWTGRFLMNLWAIFC 753

  Fly   632 LIMVSSYTANLAAFLTIENPTSPINSVKD--LADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMN 694
            :..:|:|||||||.:..|.....::.:.|  |.......::|..|..|..::...|    :.:|:
Human   754 MFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS----FPEMH 814

  Fly   695 EYLN-----AHPEML--MENNQQGVDKVKSGTKYAFLMESTSIEFNTV--RECNLTKVGDPLDEK 750
            ||:.     |.|:.:  ::|:.:.:|        ||:|:...:::...  .:|.|..||.|...:
Human   815 EYMRRYNVPATPDGVEYLKNDPEKLD--------AFIMDKALLDYEVSIDADCKLLTVGKPFAIE 871

  Fly   751 GYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGI 815
            ||||.:..|.|.....::.:.:.:..|.:..|.:||:..|..|..|....:  ..::|:.:.||:
Human   872 GYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTE--TLQMGIKHFSGL 934

  Fly   816 YVVLVIGSIISIIISI 831
            :|:|.||..:||:.:|
Human   935 FVLLCIGFGLSILTTI 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	73/388 (19%)
		ANF_receptor	46..380	CDD:279440	66/351 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	96/395 (24%)
		Lig_chan	549..819	CDD:278489	66/283 (23%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	73/379 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	66/351 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	99/420 (24%)
		Lig_chan	676..942	CDD:278489	68/287 (24%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		189/861 (22%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740